The effect of aromatic fluorine substitution in l-DOPA on the in vivo behaviour of []2-, []5- and []6-fluoro-l-DOPA in the human brain
4
Department of Radiology, Faculty of Health Sciences, 1200 Main St. West, Hamilton, Ont., Canada L8N 3Z5
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Publication type: Journal Article
Publication date: 2002-05-01
scimago Q3
wos Q3
SJR: 0.333
CiteScore: 3.7
Impact factor: 1.9
ISSN: 00221139, 18733328
Organic Chemistry
Biochemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Environmental Chemistry
Abstract
Remarkable differences in the human in vivo behaviour of each of the three [ 18 F ]-labelled ring fluorinated isomers of l -dihydroxyphenylalanine ( l -DOPA) are presented. Unlike [ 18 F ]2-fluoro- l -DOPA, which did not appear to cross the blood brain barrier, [ 18 F ]5-fluoro- l -DOPA appears to be taken up and cleared from the cerebellum and the striata. In contrast with the 2- and 5-fluoro isomers of l -DOPA, radioactivity derived after injection of [ 18 F ]6-fluoro- l -DOPA is specifically retained in the striata. The present study is the first direct comparison of the time course and distribution of radioactivity in the human brain after intravenous injections of [ 18 F ]2-, [ 18 F ]5- and [ 18 F ]6-fluoro- l -DOPA.
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GOST
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Chirakal R. et al. The effect of aromatic fluorine substitution in l-DOPA on the in vivo behaviour of []2-, []5- and []6-fluoro-l-DOPA in the human brain // Journal of Fluorine Chemistry. 2002. Vol. 115. No. 1. pp. 33-39.
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Chirakal R., Vasdev N., Asselin M., Schrobilgen G. J., Nahmias C. The effect of aromatic fluorine substitution in l-DOPA on the in vivo behaviour of []2-, []5- and []6-fluoro-l-DOPA in the human brain // Journal of Fluorine Chemistry. 2002. Vol. 115. No. 1. pp. 33-39.
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RIS
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TY - JOUR
DO - 10.1016/S0022-1139(02)00025-8
UR - https://doi.org/10.1016/S0022-1139(02)00025-8
TI - The effect of aromatic fluorine substitution in l-DOPA on the in vivo behaviour of []2-, []5- and []6-fluoro-l-DOPA in the human brain
T2 - Journal of Fluorine Chemistry
AU - Chirakal, Raman
AU - Vasdev, Neil
AU - Asselin, Marie-Claude
AU - Schrobilgen, G. J.
AU - Nahmias, Claude
PY - 2002
DA - 2002/05/01
PB - Elsevier
SP - 33-39
IS - 1
VL - 115
SN - 0022-1139
SN - 1873-3328
ER -
Cite this
BibTex (up to 50 authors)
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@article{2002_Chirakal,
author = {Raman Chirakal and Neil Vasdev and Marie-Claude Asselin and G. J. Schrobilgen and Claude Nahmias},
title = {The effect of aromatic fluorine substitution in l-DOPA on the in vivo behaviour of []2-, []5- and []6-fluoro-l-DOPA in the human brain},
journal = {Journal of Fluorine Chemistry},
year = {2002},
volume = {115},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016/S0022-1139(02)00025-8},
number = {1},
pages = {33--39},
doi = {10.1016/S0022-1139(02)00025-8}
}
Cite this
MLA
Copy
Chirakal, Raman, et al. “The effect of aromatic fluorine substitution in l-DOPA on the in vivo behaviour of []2-, []5- and []6-fluoro-l-DOPA in the human brain.” Journal of Fluorine Chemistry, vol. 115, no. 1, May. 2002, pp. 33-39. https://doi.org/10.1016/S0022-1139(02)00025-8.
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