Preparation and characterization of polymer micelles from poly(ethylene glycol)-poly(D,L-lactide) block copolymers as potential drug carrier.
Publication type: Journal Article
Publication date: 1999-11-01
scimago Q1
wos Q1
SJR: 2.470
CiteScore: 19.4
Impact factor: 11.5
ISSN: 01683659, 18734995
PubMed ID:
10518640
Pharmaceutical Science
Abstract
Poly(ethylene glycol)-poly(D,L-lactide) block copolymers (PEG-PLA) with varying composition were prepared through successive ring-opening polymerization of ethylene oxide and D,L-lactide using an anionic initiator, and their property of multimolecular micellization in aqueous milieu was examined in detail from the standpoint of designing carriers for hydrophobic drugs. The heterogeneity of PEG-PLA was found to crucially affect the size and distribution of micelles, and narrowly-distributed micelles with sizes of approximately 30 nm in diameter were formed only from PEG-PLA with a substantially narrow molecular weight distribution and an appropriate balance in the length ratio of the PEG and PLA segments in PEG-PLA, indicating the importance of establishing a reliable synthetic route for the block copolymers. PEG-PLA micelles have a considerably low critical association concentration (approximately 1.0 mg/l) which is apparently an advantage in utilizing these micelles as drug carriers in an extremely diluted condition.
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Total citations:
212
Citations from 2025:
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(2.36%)
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MLA
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GOST
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Yasugi K. et al. Preparation and characterization of polymer micelles from poly(ethylene glycol)-poly(D,L-lactide) block copolymers as potential drug carrier. // Journal of Controlled Release. 1999. Vol. 62. No. 1-2. pp. 89-100.
GOST all authors (up to 50)
Copy
Yasugi K., Nagasaki Y., Kato M., Kataoka H. Preparation and characterization of polymer micelles from poly(ethylene glycol)-poly(D,L-lactide) block copolymers as potential drug carrier. // Journal of Controlled Release. 1999. Vol. 62. No. 1-2. pp. 89-100.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/S0168-3659(99)00028-0
UR - https://doi.org/10.1016/S0168-3659(99)00028-0
TI - Preparation and characterization of polymer micelles from poly(ethylene glycol)-poly(D,L-lactide) block copolymers as potential drug carrier.
T2 - Journal of Controlled Release
AU - Yasugi, Kenji
AU - Nagasaki, Yukio
AU - Kato, Masao
AU - Kataoka, Hiromi
PY - 1999
DA - 1999/11/01
PB - Elsevier
SP - 89-100
IS - 1-2
VL - 62
PMID - 10518640
SN - 0168-3659
SN - 1873-4995
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1999_Yasugi,
author = {Kenji Yasugi and Yukio Nagasaki and Masao Kato and Hiromi Kataoka},
title = {Preparation and characterization of polymer micelles from poly(ethylene glycol)-poly(D,L-lactide) block copolymers as potential drug carrier.},
journal = {Journal of Controlled Release},
year = {1999},
volume = {62},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/S0168-3659(99)00028-0},
number = {1-2},
pages = {89--100},
doi = {10.1016/S0168-3659(99)00028-0}
}
Cite this
MLA
Copy
Yasugi, Kenji, et al. “Preparation and characterization of polymer micelles from poly(ethylene glycol)-poly(D,L-lactide) block copolymers as potential drug carrier..” Journal of Controlled Release, vol. 62, no. 1-2, Nov. 1999, pp. 89-100. https://doi.org/10.1016/S0168-3659(99)00028-0.