Hippocampal formation glucose metabolism and volume losses in MCI and AD
Susan De Santi
1
,
MONY J. DE LEON
2, 3
,
HENRY RUSINEK
4
,
A CONVIT
2, 3
,
Chaim Y. Tarshish
1
,
Alexandra Roche
1
,
Wai-Hon Tsui
3
,
Emad H. Kandil
1
,
Madhu Boppana
1
,
Katherine Daisley
1
,
GENE J. WANG
5
,
David Schlyer
6
,
Joanna Fowler
6
Publication type: Journal Article
Publication date: 2001-07-01
scimago Q1
wos Q2
SJR: 1.447
CiteScore: 7.8
Impact factor: 3.5
ISSN: 01974580, 15581497
PubMed ID:
11445252
Developmental Biology
General Neuroscience
Geriatrics and Gerontology
Aging
Neurology (clinical)
Abstract
We used MRI volume sampling with coregistered and atrophy corrected FDG-PET scans to test three hypotheses: 1) hippocampal formation measures are superior to temporal neocortical measures in the discrimination of normal (NL) and mild cognitive impairment (MCI); 2) neocortical measures are most useful in the separation of Alzheimer disease (AD) from NL or MCI; 3) measures of PET glucose metabolism (MRglu) have greater diagnostic sensitivity than MRI volume. Three groups of age, education, and gender matched NL, MCI, and AD subjects were studied. The results supported the hypotheses: 1) entorhinal cortex MRglu and hippocampal volume were most accurate in classifying NL and MCI; 2) both imaging modalities identified the temporal neocortex as best separating MCI and AD, whereas widespread changes accurately classified NL and AD; 3) In most between group comparisons regional MRglu measures were diagnostically superior to volume measures. These cross-sectional data show that in MCI hippocampal formation changes exist without significant neocortical changes. Neocortical changes best characterize AD. In both MCI and AD, metabolism reductions exceed volume losses.
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Total citations:
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Citations from 2024:
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GOST
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De Santi S. et al. Hippocampal formation glucose metabolism and volume losses in MCI and AD // Neurobiology of Aging. 2001. Vol. 22. No. 4. pp. 529-539.
GOST all authors (up to 50)
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De Santi S., DE LEON M. J., RUSINEK H., CONVIT A., Tarshish C. Y., Roche A., Tsui W., Kandil E. H., Boppana M., Daisley K., WANG G. J., Schlyer D., Fowler J. Hippocampal formation glucose metabolism and volume losses in MCI and AD // Neurobiology of Aging. 2001. Vol. 22. No. 4. pp. 529-539.
Cite this
RIS
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TY - JOUR
DO - 10.1016/S0197-4580(01)00230-5
UR - https://doi.org/10.1016/S0197-4580(01)00230-5
TI - Hippocampal formation glucose metabolism and volume losses in MCI and AD
T2 - Neurobiology of Aging
AU - De Santi, Susan
AU - DE LEON, MONY J.
AU - RUSINEK, HENRY
AU - CONVIT, A
AU - Tarshish, Chaim Y.
AU - Roche, Alexandra
AU - Tsui, Wai-Hon
AU - Kandil, Emad H.
AU - Boppana, Madhu
AU - Daisley, Katherine
AU - WANG, GENE J.
AU - Schlyer, David
AU - Fowler, Joanna
PY - 2001
DA - 2001/07/01
PB - Elsevier
SP - 529-539
IS - 4
VL - 22
PMID - 11445252
SN - 0197-4580
SN - 1558-1497
ER -
Cite this
BibTex (up to 50 authors)
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@article{2001_De Santi,
author = {Susan De Santi and MONY J. DE LEON and HENRY RUSINEK and A CONVIT and Chaim Y. Tarshish and Alexandra Roche and Wai-Hon Tsui and Emad H. Kandil and Madhu Boppana and Katherine Daisley and GENE J. WANG and David Schlyer and Joanna Fowler},
title = {Hippocampal formation glucose metabolism and volume losses in MCI and AD},
journal = {Neurobiology of Aging},
year = {2001},
volume = {22},
publisher = {Elsevier},
month = {jul},
url = {https://doi.org/10.1016/S0197-4580(01)00230-5},
number = {4},
pages = {529--539},
doi = {10.1016/S0197-4580(01)00230-5}
}
Cite this
MLA
Copy
De Santi, Susan, et al. “Hippocampal formation glucose metabolism and volume losses in MCI and AD.” Neurobiology of Aging, vol. 22, no. 4, Jul. 2001, pp. 529-539. https://doi.org/10.1016/S0197-4580(01)00230-5.