Anti-tumour platinum complexes : relationships between chemical properties and activity

Since the initi, al d i scovery by Rosenberg and Van Camp of po ten t an t i tumour ac t iv i ty in certa in p l a t i n u m amine complexes , ave have been c a r r y i n g out a p r o g r a m m e of synthes is and testing of a w i d e range of these compounds [1-4]. These s tudies have been c a r r i e d out in conjunct ion w i th a number of ins t i tu t ions in the U.K. as i n d i c a t e d in the acknowledgemen t s ~t the end of the p a p e r [5]. P l a t i num complexes of the type [Pt A S X 2] (A z = two monoden ta t e or one b identare amine ] igand ; X2 = two monoden ta te or one b iden ta te an ion ic l igand) genera ted w i d e s p r e a d r e sea rch in teres t and severa l o ther s t ruc tureac t iv i ty s tudies have been r e p o r t e d [7, 8].