Inhibition of cell cycle progression in human leukemia HL-60 cells by esculetin
1
Institute of Biochemistry, Chung‐Shan Medical University, Taichung, Taiwan
|
2
Department of Biochemistry, College of Medicine, Chung Shan Medical University, Taichung, Taiwan
|
Publication type: Journal Article
Publication date: 2002-09-01
scimago Q1
wos Q1
SJR: 2.756
CiteScore: 13.9
Impact factor: 10.1
ISSN: 03043835, 18727980
PubMed ID:
12065091
Cancer Research
Oncology
Abstract
Esculetin, a coumarin compound, was found to inhibit cell growth and cell cycle progression by inducing arrest of the G1 phase in HL-60 cells. To obtain information regarding cell cycle arrest induced by esculetin, we examined its effect on the regulating factors of the G1 phase in the leukemia HL-60 cells treated with esculetin by Western blotting. Our observations were: (1) a distinct increase in the level of hypophosphorylated retinoblastoma protein (pRb), and a reduction in the level of CDK4 after treatment with 100 microM of esculetin for 24 h; (2) a marked up-regulation of p27, and a down-regulation of cyclin D1 after treatment with 100 microM esculetin for 24 h. These results suggest that esculetin can inhibit the growth of human leukemia HL-60 cells by G1 phase cell cycle arrest as a result of inhibited pRb phosphorylation.
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GOST
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Wang C. et al. Inhibition of cell cycle progression in human leukemia HL-60 cells by esculetin // Cancer Letters. 2002. Vol. 183. No. 2. pp. 163-168.
GOST all authors (up to 50)
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Wang C., Hsieh Y., Chu C., Lin Yu., Tseng T. Inhibition of cell cycle progression in human leukemia HL-60 cells by esculetin // Cancer Letters. 2002. Vol. 183. No. 2. pp. 163-168.
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RIS
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TY - JOUR
DO - 10.1016/S0304-3835(02)00031-9
UR - https://doi.org/10.1016/S0304-3835(02)00031-9
TI - Inhibition of cell cycle progression in human leukemia HL-60 cells by esculetin
T2 - Cancer Letters
AU - Wang, Chau‐Chiung
AU - Hsieh, Yu-Cheng
AU - Chu, Chia-Huei
AU - Lin, Yu
AU - Tseng, Tsui-Hwa
PY - 2002
DA - 2002/09/01
PB - Elsevier
SP - 163-168
IS - 2
VL - 183
PMID - 12065091
SN - 0304-3835
SN - 1872-7980
ER -
Cite this
BibTex (up to 50 authors)
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@article{2002_Wang,
author = {Chau‐Chiung Wang and Yu-Cheng Hsieh and Chia-Huei Chu and Yu Lin and Tsui-Hwa Tseng},
title = {Inhibition of cell cycle progression in human leukemia HL-60 cells by esculetin},
journal = {Cancer Letters},
year = {2002},
volume = {183},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/S0304-3835(02)00031-9},
number = {2},
pages = {163--168},
doi = {10.1016/S0304-3835(02)00031-9}
}
Cite this
MLA
Copy
Wang, Chau‐Chiung, et al. “Inhibition of cell cycle progression in human leukemia HL-60 cells by esculetin.” Cancer Letters, vol. 183, no. 2, Sep. 2002, pp. 163-168. https://doi.org/10.1016/S0304-3835(02)00031-9.