A novel class of inhibitors for steroid 5α-Reductase: synthesis and evaluation of umbelliferone derivatives
Publication type: Journal Article
Publication date: 2001-09-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
11527731
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
A series of umbelliferone derivatives was prepared and their 5alpha-reductase type 1 inhibitory activities were evaluated in cell culture systems. Our studies have identified a new series of potent 5alpha-reductase type 1 inhibitors and provided the basis for further development for the treatment of human endocrine disorders associated with overproduction of DHT by 5alpha-reductase type 1. The preliminary structure-activity relationship was described to elucidate the essential structural requirements.
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Total citations:
84
Citations from 2025:
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(1.19%)
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MLA
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GOST
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Fan G. et al. A novel class of inhibitors for steroid 5α-Reductase: synthesis and evaluation of umbelliferone derivatives // Bioorganic and Medicinal Chemistry Letters. 2001. Vol. 11. No. 17. pp. 2361-2363.
GOST all authors (up to 50)
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Fan G., Mar W., Park M. S., Choi E. W., Kim K., Kim S. A novel class of inhibitors for steroid 5α-Reductase: synthesis and evaluation of umbelliferone derivatives // Bioorganic and Medicinal Chemistry Letters. 2001. Vol. 11. No. 17. pp. 2361-2363.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/S0960-894X(01)00429-2
UR - https://doi.org/10.1016/S0960-894X(01)00429-2
TI - A novel class of inhibitors for steroid 5α-Reductase: synthesis and evaluation of umbelliferone derivatives
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Fan, Gao-jun
AU - Mar, Woongchon
AU - Park, M S
AU - Choi, Eun Wan
AU - Kim, Kinam
AU - Kim, Sang-Hee
PY - 2001
DA - 2001/09/01
PB - Elsevier
SP - 2361-2363
IS - 17
VL - 11
PMID - 11527731
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2001_Fan,
author = {Gao-jun Fan and Woongchon Mar and M S Park and Eun Wan Choi and Kinam Kim and Sang-Hee Kim},
title = {A novel class of inhibitors for steroid 5α-Reductase: synthesis and evaluation of umbelliferone derivatives},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2001},
volume = {11},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/S0960-894X(01)00429-2},
number = {17},
pages = {2361--2363},
doi = {10.1016/S0960-894X(01)00429-2}
}
Cite this
MLA
Copy
Fan, Gao-jun, et al. “A novel class of inhibitors for steroid 5α-Reductase: synthesis and evaluation of umbelliferone derivatives.” Bioorganic and Medicinal Chemistry Letters, vol. 11, no. 17, Sep. 2001, pp. 2361-2363. https://doi.org/10.1016/S0960-894X(01)00429-2.