Synthesis and SAR evaluation of oxadiazolopyrazines as selective Haemophilus influenzae antibacterial agents.
Xenia Beebe
1
,
Angela M. Nilius
1
,
Philip J. Merta
1
,
Niru B. Soni
1
,
Mai Thao Bui
1
,
Rolf Wagner
1
,
Bruce A. Beutel
1
1
Infectious Disease Research, Abbott Laboratories, Abbott Park, IL 60064, USA
|
Publication type: Journal Article
Publication date: 2003-10-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
12951079
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
The parallel synthesis and antibacterial activity of 5-hydroxy[1,2,5] oxadiazolo[3,4- b ]pyrazines is reported. The compounds were synthesized by condensing diaminofurazan with α-keto acids to give a variety of aryl-substituted analogues. Halogenated phenyl groups at C -6 give rise to the greatest Haemophilus influenzae antibacterial activity. 5-Hydroxy[1,2,5]oxadiazolo[3,4- b ]pyrazines were synthesized by condensing diaminofurazan with α-keto acids to give a variety of aryl substituted analogues. Halogenated phenyl groups at C-6 give rise to the greatest Haemophilus influenzae antibacterial activity.
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GOST
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Beebe X. et al. Synthesis and SAR evaluation of oxadiazolopyrazines as selective Haemophilus influenzae antibacterial agents. // Bioorganic and Medicinal Chemistry Letters. 2003. Vol. 13. No. 19. pp. 3133-3136.
GOST all authors (up to 50)
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Beebe X., Nilius A. M., Merta P. J., Soni N. B., Bui M. T., Wagner R., Beutel B. A. Synthesis and SAR evaluation of oxadiazolopyrazines as selective Haemophilus influenzae antibacterial agents. // Bioorganic and Medicinal Chemistry Letters. 2003. Vol. 13. No. 19. pp. 3133-3136.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/S0960-894X(03)00727-3
UR - https://doi.org/10.1016/S0960-894X(03)00727-3
TI - Synthesis and SAR evaluation of oxadiazolopyrazines as selective Haemophilus influenzae antibacterial agents.
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Beebe, Xenia
AU - Nilius, Angela M.
AU - Merta, Philip J.
AU - Soni, Niru B.
AU - Bui, Mai Thao
AU - Wagner, Rolf
AU - Beutel, Bruce A.
PY - 2003
DA - 2003/10/01
PB - Elsevier
SP - 3133-3136
IS - 19
VL - 13
PMID - 12951079
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2003_Beebe,
author = {Xenia Beebe and Angela M. Nilius and Philip J. Merta and Niru B. Soni and Mai Thao Bui and Rolf Wagner and Bruce A. Beutel},
title = {Synthesis and SAR evaluation of oxadiazolopyrazines as selective Haemophilus influenzae antibacterial agents.},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2003},
volume = {13},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/S0960-894X(03)00727-3},
number = {19},
pages = {3133--3136},
doi = {10.1016/S0960-894X(03)00727-3}
}
Cite this
MLA
Copy
Beebe, Xenia, et al. “Synthesis and SAR evaluation of oxadiazolopyrazines as selective Haemophilus influenzae antibacterial agents..” Bioorganic and Medicinal Chemistry Letters, vol. 13, no. 19, Oct. 2003, pp. 3133-3136. https://doi.org/10.1016/S0960-894X(03)00727-3.