Synthesis of conformationally restricted 2′,3′- exo -Methylene carbocyclic nucleosides built on a bicyclo[3.1.0]hexane template
Тип публикации: Journal Article
Дата публикации: 2002-07-01
SCImago Q2
WOS Q1
БС1
SJR: 0.582
CiteScore: 5.6
Impact factor: 3.5
ISSN: 09680896, 14643391
PubMed ID:
11983530
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Краткое описание
A series of 2',3'-exo-methylene carbocyclic nucleosides was synthesized as potential antiviral agents. These compounds were built on a bicyclo[3.1.0]hexane template that exhibits a rigid pseudoboat conformation and is capable of maintaining an identical conformation in solid state and in solution. The structures of the synthesized compounds were elucidated by NMR and X-ray crystallography. All the compounds were tested as anti-HIV and anti-HSV agents. The chemically synthesized 5'-triphosphate analogue of 7 was evaluated directly as a reverse transcriptase inhibitor.
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Bhushan R. G., Vince R. Synthesis of conformationally restricted 2′,3′- exo -Methylene carbocyclic nucleosides built on a bicyclo[3.1.0]hexane template // Bioorganic and Medicinal Chemistry. 2002. Vol. 10. No. 7. pp. 2325-2333.
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Bhushan R. G., Vince R. Synthesis of conformationally restricted 2′,3′- exo -Methylene carbocyclic nucleosides built on a bicyclo[3.1.0]hexane template // Bioorganic and Medicinal Chemistry. 2002. Vol. 10. No. 7. pp. 2325-2333.
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TY - JOUR
DO - 10.1016/s0968-0896(02)00063-9
UR - https://doi.org/10.1016/s0968-0896(02)00063-9
TI - Synthesis of conformationally restricted 2′,3′- exo -Methylene carbocyclic nucleosides built on a bicyclo[3.1.0]hexane template
T2 - Bioorganic and Medicinal Chemistry
AU - Bhushan, Rashmi Gupta
AU - Vince, Robert
PY - 2002
DA - 2002/07/01
PB - Elsevier
SP - 2325-2333
IS - 7
VL - 10
PMID - 11983530
SN - 0968-0896
SN - 1464-3391
ER -
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@article{2002_Bhushan,
author = {Rashmi Gupta Bhushan and Robert Vince},
title = {Synthesis of conformationally restricted 2′,3′- exo -Methylene carbocyclic nucleosides built on a bicyclo[3.1.0]hexane template},
journal = {Bioorganic and Medicinal Chemistry},
year = {2002},
volume = {10},
publisher = {Elsevier},
month = {jul},
url = {https://doi.org/10.1016/s0968-0896(02)00063-9},
number = {7},
pages = {2325--2333},
doi = {10.1016/s0968-0896(02)00063-9}
}
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MLA
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Bhushan, Rashmi Gupta, and Robert Vince. “Synthesis of conformationally restricted 2′,3′- exo -Methylene carbocyclic nucleosides built on a bicyclo[3.1.0]hexane template.” Bioorganic and Medicinal Chemistry, vol. 10, no. 7, Jul. 2002, pp. 2325-2333. https://doi.org/10.1016/s0968-0896(02)00063-9.
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