5-Substituted-1H-tetrazoles as carboxylic acid isosteres: medicinal chemistry and synthetic methods
1
Medicinal Chemistry Department, Albany Molecular Research, Inc., PO Box 15098, Albany, NY 12212-5098, USA.
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Publication type: Journal Article
Publication date: 2002-11-01
scimago Q2
wos Q1
SJR: 0.608
CiteScore: 6.7
Impact factor: 3.0
ISSN: 09680896, 14643391
PubMed ID:
12213451
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
5-Substituted-1H-tetrazoles (RCN4H) are often used as metabolism-resistant isosteric replacements for carboxylic acids (RCO2H) in SAR-driven medicinal chemistry analogue syntheses. This review provides a brief summary of the medicinal chemistry of tetrazolic acids and highlights some examples of tetrazole-containing drug substances in the current literature. A survey of representative literature procedures for the preparation of 5-substituted-1H-tetrazoles, focusing on preparations from aryl and alkyl nitriles, is presented in sections by generalized synthetic methods.
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Herr R. 5-Substituted-1H-tetrazoles as carboxylic acid isosteres: medicinal chemistry and synthetic methods // Bioorganic and Medicinal Chemistry. 2002. Vol. 10. No. 11. pp. 3379-3393.
GOST all authors (up to 50)
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Herr R. 5-Substituted-1H-tetrazoles as carboxylic acid isosteres: medicinal chemistry and synthetic methods // Bioorganic and Medicinal Chemistry. 2002. Vol. 10. No. 11. pp. 3379-3393.
Cite this
RIS
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TY - JOUR
DO - 10.1016/S0968-0896(02)00239-0
UR - https://doi.org/10.1016/S0968-0896(02)00239-0
TI - 5-Substituted-1H-tetrazoles as carboxylic acid isosteres: medicinal chemistry and synthetic methods
T2 - Bioorganic and Medicinal Chemistry
AU - Herr, R.Jason
PY - 2002
DA - 2002/11/01
PB - Elsevier
SP - 3379-3393
IS - 11
VL - 10
PMID - 12213451
SN - 0968-0896
SN - 1464-3391
ER -
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BibTex (up to 50 authors)
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@article{2002_Herr,
author = {R.Jason Herr},
title = {5-Substituted-1H-tetrazoles as carboxylic acid isosteres: medicinal chemistry and synthetic methods},
journal = {Bioorganic and Medicinal Chemistry},
year = {2002},
volume = {10},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/S0968-0896(02)00239-0},
number = {11},
pages = {3379--3393},
doi = {10.1016/S0968-0896(02)00239-0}
}
Cite this
MLA
Copy
Herr, R.Jason. “5-Substituted-1H-tetrazoles as carboxylic acid isosteres: medicinal chemistry and synthetic methods.” Bioorganic and Medicinal Chemistry, vol. 10, no. 11, Nov. 2002, pp. 3379-3393. https://doi.org/10.1016/S0968-0896(02)00239-0.