Synthesis and antiparasitic activity of albendazole and mebendazole analogues
Paolo De Paoli
1
,
Lilián Yépez
2
,
Alicia Hernández-Campos
1
,
Amparo Tapia
2
,
Francisco Hernández-Luis
1
,
Roberto Cedillo
3
,
José R. González
1
,
Antonio Martı́nez-Fernández
4
,
Mercedes Martı́nez-Grueiro
4
,
Rafael Castillo
1
2
3
Publication type: Journal Article
Publication date: 2003-10-01
scimago Q2
wos Q1
SJR: 0.608
CiteScore: 6.7
Impact factor: 3.0
ISSN: 09680896, 14643391
PubMed ID:
14527558
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
Albendazole (Abz) and Mebendazole (Mbz) analogues have been synthesized and in vitro tested against the protozoa Giardia lamblia, Trichomonas vaginalis and the helminths Trichinella spiralis and Caenorhabditis elegans. Results indicate that compounds 4a, 4b (Abz analogues), 12b and 20 (Mbz analogues) are as active as antiprotozoal agents as Metronidazole against G. lamblia. Compound 9 was 58 times more active than Abz against T. vaginalis. Compounds 8 and 4a also shown high activity against this protozoan. Compounds 4b and 5a were as active as Abz. None of the Mbz analogues showed activity against T. vaginalis. The anthelmintic activity presented by these compounds was poor.
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GOST
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De Paoli P. et al. Synthesis and antiparasitic activity of albendazole and mebendazole analogues // Bioorganic and Medicinal Chemistry. 2003. Vol. 11. No. 21. pp. 4615-4622.
GOST all authors (up to 50)
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De Paoli P., Yépez L., Hernández-Campos A., Tapia A., Hernández-Luis F., Cedillo R., González J. R., Martı́nez-Fernández A., Martı́nez-Grueiro M., Castillo R. Synthesis and antiparasitic activity of albendazole and mebendazole analogues // Bioorganic and Medicinal Chemistry. 2003. Vol. 11. No. 21. pp. 4615-4622.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/S0968-0896(03)00497-8
UR - https://doi.org/10.1016/S0968-0896(03)00497-8
TI - Synthesis and antiparasitic activity of albendazole and mebendazole analogues
T2 - Bioorganic and Medicinal Chemistry
AU - De Paoli, Paolo
AU - Yépez, Lilián
AU - Hernández-Campos, Alicia
AU - Tapia, Amparo
AU - Hernández-Luis, Francisco
AU - Cedillo, Roberto
AU - González, José R.
AU - Martı́nez-Fernández, Antonio
AU - Martı́nez-Grueiro, Mercedes
AU - Castillo, Rafael
PY - 2003
DA - 2003/10/01
PB - Elsevier
SP - 4615-4622
IS - 21
VL - 11
PMID - 14527558
SN - 0968-0896
SN - 1464-3391
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2003_De Paoli,
author = {Paolo De Paoli and Lilián Yépez and Alicia Hernández-Campos and Amparo Tapia and Francisco Hernández-Luis and Roberto Cedillo and José R. González and Antonio Martı́nez-Fernández and Mercedes Martı́nez-Grueiro and Rafael Castillo},
title = {Synthesis and antiparasitic activity of albendazole and mebendazole analogues},
journal = {Bioorganic and Medicinal Chemistry},
year = {2003},
volume = {11},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/S0968-0896(03)00497-8},
number = {21},
pages = {4615--4622},
doi = {10.1016/S0968-0896(03)00497-8}
}
Cite this
MLA
Copy
De Paoli, Paolo, et al. “Synthesis and antiparasitic activity of albendazole and mebendazole analogues.” Bioorganic and Medicinal Chemistry, vol. 11, no. 21, Oct. 2003, pp. 4615-4622. https://doi.org/10.1016/S0968-0896(03)00497-8.