Immunity

, volume 11 , issue 2 , pages 253-261

2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity.

Sun-Shin CHA ¹

Min-Sung Kim ¹

Yo Han Choi ¹

Byung-Je Sung ¹

Nam Kyu Shin ²

Hang-Cheol SHIN ²

Young Soon Sung ¹

Byung-Ha Oh ¹

Hide authors affiliations Show authors affiliations: 2 affiliations

Department of Life Science and School of Environmental Engineering, Pohang University of Science and Technology, Pohang, Kyungbuk 790-784, South Korea |

Hanhyo Institute of Technology, Yusung, Taejon 305-390, South Korea |

Publication type: Journal Article

Publication date: 1999-08-01

Elsevier

Immunity

scimago Q1

wos Q1

SJR: 12.163

CiteScore: 40.8

Impact factor: 26.3

ISSN: 10747613, 10974180

DOI: 10.1016/S1074-7613(00)80100-4

Copy DOI

PubMed ID: 10485660

Infectious Diseases

Immunology

Immunology and Allergy

Abstract

TRAIL is a newly identified cytokine belonging to the large tumor necrosis factor (TNF) family. TRAIL is a novel molecule inducing apoptosis in a wide variety of tumor cells but not in normal cells. To help in elucidating its biological roles and designing mutants with improved therapeutic potential, we have determined the crystal structure of human TRAIL. The structure reveals that a unique frame insertion of 12-16 amino acids adopts a salient loop structure penetrating into the receptor-binding site. The loop drastically alters the common receptor-binding surface of the TNF family most likely for the specific recognition of cognate partners. A structure-based mutagenesis study demonstrates a critical role of the insertion loop in the cytotoxic activity of TRAIL.

Found

1 citation

Permyakov Sergei

🥼 🤝

PhD in Physics and Mathematics, associate professor

66 publications, 707 citations

h-index: 15

Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences

Institute for Biological Instrumentation of the Russian Academy of Sciences

Research interests

Calcium-binding proteins

Cellular signaling

Internally disordered proteins

Metal-binding proteins

Protein Structure

Protein-ligand interactions

Protein-protein interactions

Proteins

1 citation

Yagolovich Anne

🥼 🤝

PhD in Biological/biomedical sciences, lecturer

31 publications, 267 citations, 4 reviews

h-index: 10

Lomonosov Moscow State University

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

Research interests

Apoptosis

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GOST |

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GOST Copy

CHA S. et al. 2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity. // Immunity. 1999. Vol. 11. No. 2. pp. 253-261.

GOST all authors (up to 50) Copy

CHA S., Kim M., Choi Y. H., Sung B., Shin N. K., SHIN H., Sung Y. S., Oh B. 2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity. // Immunity. 1999. Vol. 11. No. 2. pp. 253-261.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/S1074-7613(00)80100-4

UR - https://doi.org/10.1016/S1074-7613(00)80100-4

TI - 2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity.

T2 - Immunity

AU - CHA, Sun-Shin

AU - Kim, Min-Sung

AU - Choi, Yo Han

AU - Sung, Byung-Je

AU - Shin, Nam Kyu

AU - SHIN, Hang-Cheol

AU - Sung, Young Soon

AU - Oh, Byung-Ha

PY - 1999

DA - 1999/08/01

PB - Elsevier

SP - 253-261

IS - 2

VL - 11

PMID - 10485660

SN - 1074-7613

SN - 1097-4180

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{1999_CHA,

author = {Sun-Shin CHA and Min-Sung Kim and Yo Han Choi and Byung-Je Sung and Nam Kyu Shin and Hang-Cheol SHIN and Young Soon Sung and Byung-Ha Oh},

title = {2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity.},

journal = {Immunity},

year = {1999},

volume = {11},

publisher = {Elsevier},

month = {aug},

url = {https://doi.org/10.1016/S1074-7613(00)80100-4},

number = {2},

pages = {253--261},

doi = {10.1016/S1074-7613(00)80100-4}

}

MLA

Cite this

MLA Copy

CHA, Sun-Shin, et al. “2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity..” Immunity, vol. 11, no. 2, Aug. 1999, pp. 253-261. https://doi.org/10.1016/S1074-7613(00)80100-4.

Publisher

Elsevier

Journal

Immunity

scimago Q1

wos Q1

SJR

12.163

CiteScore

40.8

Impact factor

26.3

ISSN

10747613 (Print)

10974180 (Electronic)