FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2.
Martin R. Sprick
1
,
Markus A. Weigand
2, 3
,
Eva Rieser
2
,
Charles T. Rauch
4
,
Peter Juo
5
,
John Blenis
5
,
Peter H. Krammer
2
,
Henning Walczak
2
4
Immunex Corporation, Department of Protein Chemistry, Seattle, Washington 98101, USA
|
Publication type: Journal Article
Publication date: 2000-06-01
scimago Q1
wos Q1
SJR: 12.163
CiteScore: 40.8
Impact factor: 26.3
ISSN: 10747613, 10974180
PubMed ID:
10894160
Infectious Diseases
Immunology
Immunology and Allergy
Abstract
Apoptosis induced by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL/APO-2L) has been shown to exert important functions during various immunological processes. The involvement of the death adaptor proteins FADD/MORT1, TRADD, and RIP and the apoptosis-initiating caspases-8 and -10 in death signaling by the two death-inducing TRAIL receptors 1 and 2 (TRAIL-R1 and TRAIL-R2) are controversial. Analysis of the native TRAIL death-inducing signaling complex (DISC) revealed ligand-dependent recruitment of FADD/MORT1 and caspase-8. Differential precipitation of ligand-stimulated TRAIL receptors demonstrated that FADD/MORT1 and caspase-8 were recruited to TRAIL-R1 and TRAIL-R2 independently of each other. FADD/MORT1- and caspase-8-deficient Jurkat cells expressing only TRAIL-R2 were resistant to TRAIL-induced apoptosis. Thus, FADD/MORT1 and caspase-8 are essential for apoptosis induction via TRAIL-R2.
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Total citations:
637
Citations from 2024:
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Sprick M. R. et al. FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. // Immunity. 2000. Vol. 12. No. 6. pp. 599-609.
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Sprick M. R., Weigand M. A., Rieser E., Rauch C. T., Juo P., Blenis J., Krammer P. H., Walczak H. FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. // Immunity. 2000. Vol. 12. No. 6. pp. 599-609.
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RIS
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TY - JOUR
DO - 10.1016/S1074-7613(00)80211-3
UR - https://doi.org/10.1016/S1074-7613(00)80211-3
TI - FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2.
T2 - Immunity
AU - Sprick, Martin R.
AU - Weigand, Markus A.
AU - Rieser, Eva
AU - Rauch, Charles T.
AU - Juo, Peter
AU - Blenis, John
AU - Krammer, Peter H.
AU - Walczak, Henning
PY - 2000
DA - 2000/06/01
PB - Elsevier
SP - 599-609
IS - 6
VL - 12
PMID - 10894160
SN - 1074-7613
SN - 1097-4180
ER -
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BibTex (up to 50 authors)
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@article{2000_Sprick,
author = {Martin R. Sprick and Markus A. Weigand and Eva Rieser and Charles T. Rauch and Peter Juo and John Blenis and Peter H. Krammer and Henning Walczak},
title = {FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2.},
journal = {Immunity},
year = {2000},
volume = {12},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/S1074-7613(00)80211-3},
number = {6},
pages = {599--609},
doi = {10.1016/S1074-7613(00)80211-3}
}
Cite this
MLA
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Sprick, Martin R., et al. “FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2..” Immunity, vol. 12, no. 6, Jun. 2000, pp. 599-609. https://doi.org/10.1016/S1074-7613(00)80211-3.