Immunity

, том 12 , издание 6 , страницы 599-609

FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2.

Martin R. Sprick ¹

Markus A. Weigand ^{2, 3}

Eva Rieser ²

Charles T. Rauch ⁴

Peter Juo ⁵

John Blenis ⁵

Peter H. Krammer ²

Henning Walczak ²

Скрыть аффилиации авторов Показать аффилиации авторов: 5 аффилиаций

Tumor Immunology Program, German Cancer Research Center (DKFZ) Heidelberg. |

Tumor Immunology Program, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany |

University of Heidelberg, Clinic of Anesthesiology, D-69120 Heidelberg, Germany |

⁴

Immunex Corporation, Department of Protein Chemistry, Seattle, Washington 98101, USA |

⁵

Harvard Medical School, Department of Cell Biology, Boston, Massachusetts 02115, USA |

Тип публикации: Journal Article

Дата публикации: 2000-06-01

Elsevier

Immunity

scimago Q1

wos Q1

БС1

SJR: 12.163

CiteScore: 40.8

Impact factor: 26.3

ISSN: 10747613, 10974180

DOI: 10.1016/S1074-7613(00)80211-3

Скопировать DOI

PubMed ID: 10894160

Infectious Diseases

Immunology

Immunology and Allergy

Краткое описание

Apoptosis induced by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL/APO-2L) has been shown to exert important functions during various immunological processes. The involvement of the death adaptor proteins FADD/MORT1, TRADD, and RIP and the apoptosis-initiating caspases-8 and -10 in death signaling by the two death-inducing TRAIL receptors 1 and 2 (TRAIL-R1 and TRAIL-R2) are controversial. Analysis of the native TRAIL death-inducing signaling complex (DISC) revealed ligand-dependent recruitment of FADD/MORT1 and caspase-8. Differential precipitation of ligand-stimulated TRAIL receptors demonstrated that FADD/MORT1 and caspase-8 were recruited to TRAIL-R1 and TRAIL-R2 independently of each other. FADD/MORT1- and caspase-8-deficient Jurkat cells expressing only TRAIL-R2 were resistant to TRAIL-induced apoptosis. Thus, FADD/MORT1 and caspase-8 are essential for apoptosis induction via TRAIL-R2.

Найдено

1 цитирование

Трушина Дарья

🥼 🤝

к.ф.-м.н.

53 публикации, 1 265 цитирований, 20 рецензий

Индекс Хирша: 16

Курчатовский комплекс "Кристаллография и Фотоника"

Первый Московский государственный медицинский университет имени И. М. Сеченова

Области научных интересов

Персонализированная медицина

Супрамолекулярная химия

Химическая физика

1 цитирование

Яголович Анна

🥼 🤝

к.б.н., ассистент

31 публикация, 279 цитирований, 4 рецензии

Индекс Хирша: 10

Московский государственный университет имени М.В. Ломоносова

Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН

Области научных интересов

Апоптоз

1 цитирование

Купраш Дмитрий

д.б.н., проф., ч.-к., Российская академия наук

127 публикаций, 3 267 цитирований

Индекс Хирша: 31

Московский государственный университет имени М.В. Ломоносова

Московский физико-технический институт

Институт молекулярной биологии им. В.А. Энгельгардта РАН

Топ-30

Журналы

	5 10 15 20 25 30 35 40 45 50
Journal of Biological Chemistry	Journal of Biological Chemistry, 47, 7.37% Journal of Biological Chemistry 47 публикаций, 7.37%
Cell Death and Differentiation	Cell Death and Differentiation, 28, 4.39% Cell Death and Differentiation 28 публикаций, 4.39%
Oncogene	Oncogene, 28, 4.39% Oncogene 28 публикаций, 4.39%
Cell Death and Disease	Cell Death and Disease, 15, 2.35% Cell Death and Disease 15 публикаций, 2.35%
Cancer Research	Cancer Research, 12, 1.88% Cancer Research 12 публикаций, 1.88%
Vitamins and Hormones	Vitamins and Hormones, 12, 1.88% Vitamins and Hormones 12 публикаций, 1.88%
Journal of Immunology	Journal of Immunology, 11, 1.72% Journal of Immunology 11 публикаций, 1.72%
Apoptosis : an international journal on programmed cell death	Apoptosis : an international journal on programmed cell death, 11, 1.72% Apoptosis : an international journal on programmed cell death 11 публикаций, 1.72%
Blood	Blood, 10, 1.57% Blood 10 публикаций, 1.57%
Cancers	Cancers, 9, 1.41% Cancers 9 публикаций, 1.41%
Cancer Letters	Cancer Letters, 9, 1.41% Cancer Letters 9 публикаций, 1.41%
Molecular Cancer Therapeutics	Molecular Cancer Therapeutics, 9, 1.41% Molecular Cancer Therapeutics 9 публикаций, 1.41%
International Journal of Cancer	International Journal of Cancer, 8, 1.25% International Journal of Cancer 8 публикаций, 1.25%
Molecular and Cellular Biology	Molecular and Cellular Biology, 8, 1.25% Molecular and Cellular Biology 8 публикаций, 1.25%
Biochemical and Biophysical Research Communications	Biochemical and Biophysical Research Communications, 7, 1.1% Biochemical and Biophysical Research Communications 7 публикаций, 1.1%
Cells	Cells, 7, 1.1% Cells 7 публикаций, 1.1%
PLoS ONE	PLoS ONE, 7, 1.1% PLoS ONE 7 публикаций, 1.1%
Oncotarget	Oncotarget, 6, 0.94% Oncotarget 6 публикаций, 0.94%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 6, 0.94% International Journal of Molecular Sciences 6 публикаций, 0.94%
Leukemia	Leukemia, 6, 0.94% Leukemia 6 публикаций, 0.94%
Journal of Cellular Biochemistry	Journal of Cellular Biochemistry, 6, 0.94% Journal of Cellular Biochemistry 6 публикаций, 0.94%
FEBS Journal	FEBS Journal, 6, 0.94% FEBS Journal 6 публикаций, 0.94%
Molecular Cancer Research	Molecular Cancer Research, 6, 0.94% Molecular Cancer Research 6 публикаций, 0.94%
Nature Reviews Cancer	Nature Reviews Cancer, 5, 0.78% Nature Reviews Cancer 5 публикаций, 0.78%
Nature Medicine	Nature Medicine, 5, 0.78% Nature Medicine 5 публикаций, 0.78%
FEBS Letters	FEBS Letters, 5, 0.78% FEBS Letters 5 публикаций, 0.78%
Proceedings of the National Academy of Sciences of the United States of America	Proceedings of the National Academy of Sciences of the United States of America, 5, 0.78% Proceedings of the National Academy of Sciences of the United States of America 5 публикаций, 0.78%
Neoplasia	Neoplasia, 4, 0.63% Neoplasia 4 публикации, 0.63%
Experimental Hematology	Experimental Hematology, 4, 0.63% Experimental Hematology 4 публикации, 0.63%
	5 10 15 20 25 30 35 40 45 50

Издатели

	20 40 60 80 100 120 140 160 180
Springer Nature	Springer Nature, 164, 25.71% Springer Nature 164 публикации, 25.71%
Elsevier	Elsevier, 144, 22.57% Elsevier 144 публикации, 22.57%
Wiley	Wiley, 74, 11.6% Wiley 74 публикации, 11.6%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 47, 7.37% American Society for Biochemistry and Molecular Biology 47 публикаций, 7.37%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 28, 4.39% American Association for Cancer Research (AACR) 28 публикаций, 4.39%
MDPI	MDPI, 26, 4.08% MDPI 26 публикаций, 4.08%
Taylor & Francis	Taylor & Francis, 14, 2.19% Taylor & Francis 14 публикаций, 2.19%
The American Association of Immunologists	The American Association of Immunologists, 11, 1.72% The American Association of Immunologists 11 публикаций, 1.72%
American Society for Microbiology	American Society for Microbiology, 11, 1.72% American Society for Microbiology 11 публикаций, 1.72%
American Society of Hematology	American Society of Hematology, 10, 1.57% American Society of Hematology 10 публикаций, 1.57%
Frontiers Media S.A.	Frontiers Media S.A., 8, 1.25% Frontiers Media S.A. 8 публикаций, 1.25%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 7, 1.1% Public Library of Science (PLoS) 7 публикаций, 1.1%
Impact Journals	Impact Journals, 6, 0.94% Impact Journals 6 публикаций, 0.94%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 5, 0.78% Proceedings of the National Academy of Sciences (PNAS) 5 публикаций, 0.78%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 5, 0.78% Cold Spring Harbor Laboratory 5 публикаций, 0.78%
Ovid Technologies (Wolters Kluwer Health)	Ovid Technologies (Wolters Kluwer Health), 4, 0.63% Ovid Technologies (Wolters Kluwer Health) 4 публикации, 0.63%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 4, 0.63% Royal Society of Chemistry (RSC) 4 публикации, 0.63%
Oxford University Press	Oxford University Press, 4, 0.63% Oxford University Press 4 публикации, 0.63%
Rockefeller University Press	Rockefeller University Press, 4, 0.63% Rockefeller University Press 4 публикации, 0.63%
American Society for Clinical Investigation	American Society for Clinical Investigation, 3, 0.47% American Society for Clinical Investigation 3 публикации, 0.47%
Bentham Science Publishers Ltd.	Bentham Science Publishers Ltd., 3, 0.47% Bentham Science Publishers Ltd. 3 публикации, 0.47%
The Company of Biologists	The Company of Biologists, 3, 0.47% The Company of Biologists 3 публикации, 0.47%
European Molecular Biology Organization	European Molecular Biology Organization, 3, 0.47% European Molecular Biology Organization 3 публикации, 0.47%
American Chemical Society (ACS)	American Chemical Society (ACS), 3, 0.47% American Chemical Society (ACS) 3 публикации, 0.47%
Asian Pacific Organization for Cancer Prevention	Asian Pacific Organization for Cancer Prevention, 3, 0.47% Asian Pacific Organization for Cancer Prevention 3 публикации, 0.47%
IMR Press	IMR Press, 3, 0.47% IMR Press 3 публикации, 0.47%
Mary Ann Liebert	Mary Ann Liebert, 2, 0.31% Mary Ann Liebert 2 публикации, 0.31%
Portland Press	Portland Press, 2, 0.31% Portland Press 2 публикации, 0.31%
SAGE	SAGE, 2, 0.31% SAGE 2 публикации, 0.31%
	20 40 60 80 100 120 140 160 180

Мы не учитываем публикации, у которых нет DOI.
Статистика публикаций обновляется еженедельно.

Вы ученый?

Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.

Войти с ORCID

Метрики

638

Цитировать

ГОСТ |

Цитировать

ГОСТ Скопировать

Sprick M. R. et al. FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. // Immunity. 2000. Vol. 12. No. 6. pp. 599-609.

ГОСТ со всеми авторами (до 50) Скопировать

Sprick M. R., Weigand M. A., Rieser E., Rauch C. T., Juo P., Blenis J., Krammer P. H., Walczak H. FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. // Immunity. 2000. Vol. 12. No. 6. pp. 599-609.

RIS |

Цитировать

RIS Скопировать

TY - JOUR

DO - 10.1016/S1074-7613(00)80211-3

UR - https://doi.org/10.1016/S1074-7613(00)80211-3

TI - FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2.

T2 - Immunity

AU - Sprick, Martin R.

AU - Weigand, Markus A.

AU - Rieser, Eva

AU - Rauch, Charles T.

AU - Juo, Peter

AU - Blenis, John

AU - Krammer, Peter H.

AU - Walczak, Henning

PY - 2000

DA - 2000/06/01

PB - Elsevier

SP - 599-609

IS - 6

VL - 12

PMID - 10894160

SN - 1074-7613

SN - 1097-4180

ER -

BibTex |

Цитировать

BibTex (до 50 авторов) Скопировать

@article{2000_Sprick,

author = {Martin R. Sprick and Markus A. Weigand and Eva Rieser and Charles T. Rauch and Peter Juo and John Blenis and Peter H. Krammer and Henning Walczak},

title = {FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2.},

journal = {Immunity},

year = {2000},

volume = {12},

publisher = {Elsevier},

month = {jun},

url = {https://doi.org/10.1016/S1074-7613(00)80211-3},

number = {6},

pages = {599--609},

doi = {10.1016/S1074-7613(00)80211-3}

}

MLA

Цитировать

MLA Скопировать

Sprick, Martin R., et al. “FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2..” Immunity, vol. 12, no. 6, Jun. 2000, pp. 599-609. https://doi.org/10.1016/S1074-7613(00)80211-3.

Издатель

Elsevier

Журнал

Immunity

scimago Q1

wos Q1

БС1

SJR

12.163

CiteScore

40.8

Impact factor

26.3

ISSN

10747613 (Print)

10974180 (Electronic)