The Lancet Respiratory Medicine, volume 10, issue 10, pages 985-996
Efficacy and safety of intramuscular administration of tixagevimab–cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-controlled trial
HUGH MONTGOMERY
,
F.D. Richard Hobbs
,
Francisco Padilla
,
Douglas Arbetter
,
Alison Templeton
,
Seth Seegobin
,
KENNETH KIM
,
Jesus Abraham Simón Campos
,
Rosalinda H. Arends
,
Bryan H Brodek
,
Dennis Brooks
,
Pedro Garbes
,
Julieta Jimenez
,
Gavin C K W Koh
,
Kelly W. Padilla
,
Katie Streicher
,
Rolando M Viani
,
Vijay Alagappan
,
Menelas N. Pangalos
,
Mark T Esser
,
Wakana Abe
,
Tania Adan De Varona
,
Daria Adiatullina
,
Daniel Aguilar Zapata
,
Kevin Ahlers
,
Carolina Aimo
,
Ayoade Akere
,
Elena Akimova
,
Jorge Alatorre Alexander
,
Logan Aldrich
,
Ismael Ali Garcia
,
Karim Ali García
,
Lee Allison
,
Rosa Alonso Zuñiga
,
Ivan Aloysius
,
Javier Altclas
,
Andres Alvarisqueta
,
Martti Antila
,
Camila Anton
,
Elisabet Árboix Alamo
,
Samir Arora
,
Ramón Alejandro Avilés Felix
,
Natalya Bakhtina
,
Varenka Barbero-Becerra
,
Armando Barragan-Reyes
,
Alejandro Barreira
,
Barrett Mitchell
,
Jiri Beran
,
Nikolett Berki
,
Viktoria Berki
,
Richard Betten
,
Claudia Binelli
,
Lenka Brunzová
,
Cecilia Bussolari
,
Karianna Byargeon
,
Justyna Bytnar
,
Carlos Camberos
,
Pedro Campos Corzo
,
Grazia Cannon
,
Valentina Canovi
,
Simone Carla da Rosa
,
Ana Caroline Moser
,
Luis Carrera Rivas
,
Marcelo Martin Casas
,
Paulo Castañeda-Méndez
,
Ana Cavalcante
,
Eugenia Cherepova
,
Alexei Chermenskii
,
Lauren Clark
,
Mauro Codeluppi
,
Flavia Coelho
,
Belinda Contreras
,
Alex Cran
,
Taylor Dao
,
Chrisette Dharma
,
Cosimo Di Castri
,
Victoria Diaz Balocchi
,
Omar Durán
,
Kara Earl
,
Adam Ellery
,
Tomoko Endo
,
Andrea Everding
,
Rainald Fischer
,
Benedito Fonseca
,
Chelsea C. Franklin
,
Susan-Beatrice Franz
,
Anna Fumagalli
,
Mauricio Galindo-Amaya
,
Mariagiulia Galli
,
Laura Gerna
,
Karolly Gil Ureña
,
Henrikki Gomes Antila
,
Laura Ines Gomes Maricato
,
Gabriela Goncalvez
,
Martin Gonzalez
,
Jesús González-Lama
,
Stephen Granier
,
Jacob Granier
,
Stephan Grunwald
,
David Guardeño-Ropero
,
Monica Guberti
,
Sridhar Guduri
,
Carolina Guerrero García
,
Jehad Haggiagi
,
Kacie Hale
,
Toshimasa Hayashi
,
Maiara Hermes
,
Dante Hernandez Colin
,
Yuji Hirai
,
Masayuki Hojo
,
Tetsuya Homma
,
Billy Hour
,
Andreas Huber
,
Diego Iacovelli
,
Noriomi Ishibashi
,
Yutaro Iwabe
,
Shinyu Izumi
,
Arne Jessen
,
Heiko Jessen
,
Wilner Jeudy
,
Marta Jiménez Marcos
,
Rebecca Johnson
,
Eva Juárez-Hernández
,
Kiyomi Kabasawa
,
Katarzyna Kamińska
,
Megumi Kawabe
,
Angela Kemp
,
Oleg Khmelnitskiy
,
Carina Klassen
,
Olena Kobrynska
,
Pavel Koleckar
,
Stephanie Korn
,
Marc Kornmann
,
Viktor Kostenko
,
Evgenii Kovalchuk
,
Yana Kovalchuk
,
Tim Kümmerle
,
Ulrike Lachmund
,
Kerstin Lammersmann
,
Flávio Lastebasse
,
Ivana Lattuada
,
Felicitas Lauer
,
Kyrylo Lebed
,
Olga Lebed
,
Diego Lecona-Garcia
,
Maria Christina Leoni
,
Marina Lima
,
Raymond Little
,
Holly Little
,
Andrea Lizardi-Díaz
,
Michele Lobo-Becker
,
Francesco Luppi
,
Veronica Macias
,
Shigefumi MAESAKI
,
Cristiano Magnaghi
,
Annalisa Mancini
,
Stanisław Mazur
,
Tatiana Melnikova
,
Sergio Menchaca
,
Ibrahim Menendez-Perez
,
Ewa Międlar
,
Shuuichi Mizunuma
,
Anastasiya Mochalova
,
Mihad Mohamed
,
Theresa Moll
,
Camila Montalvo
,
Amber Mottola
,
Birgit Mück
,
Rebeca Mussi Brugnolli
,
Akanksha Nanda
,
Dörthe Neuner
,
Agatha Ngwueke
,
Sebastian Noe
,
Martin Novacek
,
Laura Nuzzolo-Shihadeh
,
Emeka Obiekwe
,
Isaias G. Ocampo Gaytán
,
Norio Ohmagari
,
Shin Ohta
,
Ptuonye Onyewuchi
,
Iurii Pankov
,
Maurício Pedrosa
,
Yael Peré
,
Alejandro Pereyra
,
Eliana Perez
,
Eduardo Perez-Alba
,
Paloma Perpiña Lozano
,
Tanya Perrei
,
Dena Peterson
,
Ligia Pierroti
,
Felipe Pineda-Cárdenas
,
Teresa Plascencia Sanchez
,
Camila Poletti
,
Chiara Pomaranzi
,
Lisette Portes
,
Nils Postel
,
Monica Ramirez
,
Isabel Ramírez
,
Miguel Ramirez-Baena
,
Mahadev Ramjee
,
Giovanna Ratti
,
Jackie Reeve
,
Petr Reichert
,
Petra Reichertová
,
Edgar Alejandro Reyes Garcia
,
Celso Ricardo
,
Nicomedes Rodríguez Rodríguez
,
Jaun Roldán Sánchez
,
Matilde Romero-Lopez
,
Tyrone Rosales
,
Harvey Rosales
,
Mohamed Roshan
,
Simran Roshan
,
Patrizia Rovere Querini
,
Heather Rutter
,
Sadaf Sachwani
,
Hironori Sagara
,
Jun Sakai
,
Nina Samson
,
José Héctor Sánchez Mijangos
,
Liliana Sánchez
,
Ana Sánchez-González
,
Micko Sandford
,
Laura Santana
,
Felipe Santos de Carvalho
,
Reiko Sasao
,
Lubna Sato
,
Elizabeth Scheuermann
,
Olaf Schmidt
,
Masafumi Seki
,
Safia Shaikh
,
Daishi Shimada
,
Masaharu Shinkai
,
Masahiro Shinoda
,
Jackie Smith
,
Fernando Solorzano
,
Silvia Soncini
,
Katalin Soregine
,
Erica Sosa
,
Olalekan Sowade
,
Veronika Špinková
,
Ruth Staniford
,
Iska Steigemann
,
Vivien Steiner
,
Vladimir Strelkov
,
Cintya R. Suárez Pineda
,
Hiroki Suenaga
,
Shintaro Suzaki
,
Hannah Swayze
,
Yuji Tada
,
Yuichiro Takeshita
,
Yasuo Takiguchi
,
Akihiko Tanaka
,
Norihito Tarumoto
,
Albina Tatarintseva
,
Michelle Taubert
,
Elizaveta Terenya
,
César Tinoco
,
Tomohiro Tomiyasu
,
Gladys Torres-Vidal
,
Gabriela Trejo-Aguiar
,
Kenji Tsushima
,
Emma Tunstall
,
Caterina Turrà
,
Yoandy Valdes
,
Nelly Valencia Castro
,
Guilherme Visconti
,
Giordano Vitali
,
Apinya Vutikullird
,
Jezdancher Watti
,
Doreen Werth
,
Cheyanne Wilson
,
Philippe Wilson
,
Amy Workman
,
Pamela Wörle
,
Christoph Wyen
,
Yoshiko Yamaguchi
,
Kei Yamamoto
Publication type: Journal Article
Publication date: 2022-10-01
Journal:
The Lancet Respiratory Medicine
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 76.2
ISSN: 22132600, 22132619
Pulmonary and Respiratory Medicine
Abstract
Early intramuscular administration of SARS-CoV-2-neutralising monoclonal antibody combination, tixagevimab-cilgavimab, to non-hospitalised adults with mild to moderate COVID-19 has potential to prevent disease progression. We aimed to evaluate the safety and efficacy of tixagevimab-cilgavimab in preventing progression to severe COVID-19 or death.TACKLE is an ongoing, phase 3, randomised, double-blind, placebo-controlled study conducted at 95 sites in the USA, Latin America, Europe, and Japan. Eligible participants were non-hospitalised adults aged 18 years or older with a laboratory-confirmed SARS-CoV-2 infection (determined by RT-PCR or an antigen test) from any respiratory tract specimen collected 3 days or less before enrolment and who had not received a COVID-19 vaccination. A WHO Clinical Progression Scale score from more than 1 to less than 4 was required for inclusion and participants had to receive the study drug 7 days or less from self-reported onset of mild to moderate COVID-19 symptoms or measured fever. Participants were randomly assigned (1:1) to receive either a single tixagevimab-cilgavimab 600 mg dose (two consecutive 3 mL intramuscular injections, one each of 300 mg tixagevimab and 300 mg cilgavimab) or placebo. Randomisation was stratified (using central blocked randomisation with randomly varying block sizes) by time from symptom onset, and high-risk versus low-risk of progression to severe COVID-19. Participants, investigators, and sponsor staff involved in the treatment or clinical evaluation and monitoring of the participants were masked to treatment-group assignments. The primary endpoints were severe COVID-19 or death from any cause through to day 29, and safety. This study is registered with ClinicalTrials.gov, NCT04723394.Between Jan 28, 2021, and July 22, 2021, 1014 participants were enrolled, of whom 910 were randomly assigned to a treatment group (456 to receive tixagevimab-cilgavimab and 454 to receive placebo). The mean age of participants was 46·1 years (SD 15·2). Severe COVID-19 or death occurred in 18 (4%) of 407 participants in the tixagevimab-cilgavimab group versus 37 (9%) of 415 participants in the placebo group (relative risk reduction 50·5% [95% CI 14·6-71·3]; p=0·0096). The absolute risk reduction was 4·5% (95% CI 1·1-8·0; p<0·0001). Adverse events occurred in 132 (29%) of 452 participants in the tixagevimab-cilgavimab group and 163 (36%) of 451 participants in the placebo group, and were mostly of mild or moderate severity. There were three COVID-19-reported deaths in the tixagevimab-cilgavimab group and six in the placebo group.A single intramuscular tixagevimab-cilgavimab dose provided statistically and clinically significant protection against progression to severe COVID-19 or death versus placebo in unvaccinated individuals and safety was favourable. Treating mild to moderate COVID-19 earlier in the disease course with tixagevimab-cilgavimab might lead to more favourable outcomes.AstraZeneca.
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MONTGOMERY H. et al. Efficacy and safety of intramuscular administration of tixagevimab–cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-controlled trial // The Lancet Respiratory Medicine. 2022. Vol. 10. No. 10. pp. 985-996.
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MONTGOMERY H. et al. Efficacy and safety of intramuscular administration of tixagevimab–cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-controlled trial // The Lancet Respiratory Medicine. 2022. Vol. 10. No. 10. pp. 985-996.
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TY - JOUR
DO - 10.1016/S2213-2600(22)00180-1
UR - https://doi.org/10.1016/S2213-2600(22)00180-1
TI - Efficacy and safety of intramuscular administration of tixagevimab–cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-controlled trial
T2 - The Lancet Respiratory Medicine
AU - MONTGOMERY, HUGH
AU - Hobbs, F.D. Richard
AU - Padilla, Francisco
AU - Arbetter, Douglas
AU - Templeton, Alison
AU - Seegobin, Seth
AU - KIM, KENNETH
AU - Campos, Jesus Abraham Simón
AU - Arends, Rosalinda H.
AU - Brodek, Bryan H
AU - Brooks, Dennis
AU - Garbes, Pedro
AU - Jimenez, Julieta
AU - Koh, Gavin C K W
AU - Padilla, Kelly W.
AU - Streicher, Katie
AU - Viani, Rolando M
AU - Alagappan, Vijay
AU - Pangalos, Menelas N.
AU - Esser, Mark T
AU - Abe, Wakana
AU - Adan De Varona, Tania
AU - Adiatullina, Daria
AU - Aguilar Zapata, Daniel
AU - Ahlers, Kevin
AU - Aimo, Carolina
AU - Akere, Ayoade
AU - Akimova, Elena
AU - Alatorre Alexander, Jorge
AU - Aldrich, Logan
AU - Ali Garcia, Ismael
AU - Ali García, Karim
AU - Allison, Lee
AU - Alonso Zuñiga, Rosa
AU - Aloysius, Ivan
AU - Altclas, Javier
AU - Alvarisqueta, Andres
AU - Antila, Martti
AU - Anton, Camila
AU - Árboix Alamo, Elisabet
AU - Arora, Samir
AU - Avilés Felix, Ramón Alejandro
AU - Bakhtina, Natalya
AU - Barbero-Becerra, Varenka
AU - Barragan-Reyes, Armando
AU - Barreira, Alejandro
AU - Mitchell, Barrett
AU - Beran, Jiri
AU - Berki, Nikolett
AU - Berki, Viktoria
AU - Betten, Richard
AU - Binelli, Claudia
AU - Brunzová, Lenka
AU - Bussolari, Cecilia
AU - Byargeon, Karianna
AU - Bytnar, Justyna
AU - Camberos, Carlos
AU - Campos Corzo, Pedro
AU - Cannon, Grazia
AU - Canovi, Valentina
AU - Carla da Rosa, Simone
AU - Moser, Ana Caroline
AU - Carrera Rivas, Luis
AU - Casas, Marcelo Martin
AU - Castañeda-Méndez, Paulo
AU - Cavalcante, Ana
AU - Cherepova, Eugenia
AU - Chermenskii, Alexei
AU - Clark, Lauren
AU - Codeluppi, Mauro
AU - Coelho, Flavia
AU - Contreras, Belinda
AU - Cran, Alex
AU - Dao, Taylor
AU - Dharma, Chrisette
AU - Di Castri, Cosimo
AU - Diaz Balocchi, Victoria
AU - Durán, Omar
AU - Earl, Kara
AU - Ellery, Adam
AU - Endo, Tomoko
AU - Everding, Andrea
AU - Fischer, Rainald
AU - Fonseca, Benedito
AU - Franklin, Chelsea C.
AU - Franz, Susan-Beatrice
AU - Fumagalli, Anna
AU - Galindo-Amaya, Mauricio
AU - Galli, Mariagiulia
AU - Gerna, Laura
AU - Gil Ureña, Karolly
AU - Gomes Antila, Henrikki
AU - Gomes Maricato, Laura Ines
AU - Goncalvez, Gabriela
AU - Gonzalez, Martin
AU - González-Lama, Jesús
AU - Granier, Stephen
AU - Granier, Jacob
AU - Grunwald, Stephan
AU - Guardeño-Ropero, David
AU - Guberti, Monica
AU - Guduri, Sridhar
AU - Guerrero García, Carolina
AU - Haggiagi, Jehad
AU - Hale, Kacie
AU - Hayashi, Toshimasa
AU - Hermes, Maiara
AU - Hernandez Colin, Dante
AU - Hirai, Yuji
AU - Hojo, Masayuki
AU - Homma, Tetsuya
AU - Hour, Billy
AU - Huber, Andreas
AU - Iacovelli, Diego
AU - Ishibashi, Noriomi
AU - Iwabe, Yutaro
AU - Izumi, Shinyu
AU - Jessen, Arne
AU - Jessen, Heiko
AU - Jeudy, Wilner
AU - Jiménez Marcos, Marta
AU - Johnson, Rebecca
AU - Juárez-Hernández, Eva
AU - Kabasawa, Kiyomi
AU - Kamińska, Katarzyna
AU - Kawabe, Megumi
AU - Kemp, Angela
AU - Khmelnitskiy, Oleg
AU - Klassen, Carina
AU - Kobrynska, Olena
AU - Koleckar, Pavel
AU - Korn, Stephanie
AU - Kornmann, Marc
AU - Kostenko, Viktor
AU - Kovalchuk, Evgenii
AU - Kovalchuk, Yana
AU - Kümmerle, Tim
AU - Lachmund, Ulrike
AU - Lammersmann, Kerstin
AU - Lastebasse, Flávio
AU - Lattuada, Ivana
AU - Lauer, Felicitas
AU - Lebed, Kyrylo
AU - Lebed, Olga
AU - Lecona-Garcia, Diego
AU - Leoni, Maria Christina
AU - Lima, Marina
AU - Little, Raymond
AU - Little, Holly
AU - Lizardi-Díaz, Andrea
AU - Lobo-Becker, Michele
AU - Luppi, Francesco
AU - Macias, Veronica
AU - MAESAKI, Shigefumi
AU - Magnaghi, Cristiano
AU - Mancini, Annalisa
AU - Mazur, Stanisław
AU - Melnikova, Tatiana
AU - Menchaca, Sergio
AU - Menendez-Perez, Ibrahim
AU - Międlar, Ewa
AU - Mizunuma, Shuuichi
AU - Mochalova, Anastasiya
AU - Mohamed, Mihad
AU - Moll, Theresa
AU - Montalvo, Camila
AU - Mottola, Amber
AU - Mück, Birgit
AU - Mussi Brugnolli, Rebeca
AU - Nanda, Akanksha
AU - Neuner, Dörthe
AU - Ngwueke, Agatha
AU - Noe, Sebastian
AU - Novacek, Martin
AU - Nuzzolo-Shihadeh, Laura
AU - Obiekwe, Emeka
AU - Ocampo Gaytán, Isaias G.
AU - Ohmagari, Norio
AU - Ohta, Shin
AU - Onyewuchi, Ptuonye
AU - Pankov, Iurii
AU - Pedrosa, Maurício
AU - Peré, Yael
AU - Pereyra, Alejandro
AU - Perez, Eliana
AU - Perez-Alba, Eduardo
AU - Perpiña Lozano, Paloma
AU - Perrei, Tanya
AU - Peterson, Dena
AU - Pierroti, Ligia
AU - Pineda-Cárdenas, Felipe
AU - Plascencia Sanchez, Teresa
AU - Poletti, Camila
AU - Pomaranzi, Chiara
AU - Portes, Lisette
AU - Postel, Nils
AU - Ramirez, Monica
AU - Ramírez, Isabel
AU - Ramirez-Baena, Miguel
AU - Ramjee, Mahadev
AU - Ratti, Giovanna
AU - Reeve, Jackie
AU - Reichert, Petr
AU - Reichertová, Petra
AU - Reyes Garcia, Edgar Alejandro
AU - Ricardo, Celso
AU - Rodríguez Rodríguez, Nicomedes
AU - Roldán Sánchez, Jaun
AU - Romero-Lopez, Matilde
AU - Rosales, Tyrone
AU - Rosales, Harvey
AU - Roshan, Mohamed
AU - Roshan, Simran
AU - Rovere Querini, Patrizia
AU - Rutter, Heather
AU - Sachwani, Sadaf
AU - Sagara, Hironori
AU - Sakai, Jun
AU - Samson, Nina
AU - Sánchez Mijangos, José Héctor
AU - Sánchez, Liliana
AU - Sánchez-González, Ana
AU - Sandford, Micko
AU - Santana, Laura
AU - Santos de Carvalho, Felipe
AU - Sasao, Reiko
AU - Sato, Lubna
AU - Scheuermann, Elizabeth
AU - Schmidt, Olaf
AU - Seki, Masafumi
AU - Shaikh, Safia
AU - Shimada, Daishi
AU - Shinkai, Masaharu
AU - Shinoda, Masahiro
AU - Smith, Jackie
AU - Solorzano, Fernando
AU - Soncini, Silvia
AU - Soregine, Katalin
AU - Sosa, Erica
AU - Sowade, Olalekan
AU - Špinková, Veronika
AU - Staniford, Ruth
AU - Steigemann, Iska
AU - Steiner, Vivien
AU - Strelkov, Vladimir
AU - Suárez Pineda, Cintya R.
AU - Suenaga, Hiroki
AU - Suzaki, Shintaro
AU - Swayze, Hannah
AU - Tada, Yuji
AU - Takeshita, Yuichiro
AU - Takiguchi, Yasuo
AU - Tanaka, Akihiko
AU - Tarumoto, Norihito
AU - Tatarintseva, Albina
AU - Taubert, Michelle
AU - Terenya, Elizaveta
AU - Tinoco, César
AU - Tomiyasu, Tomohiro
AU - Torres-Vidal, Gladys
AU - Trejo-Aguiar, Gabriela
AU - Tsushima, Kenji
AU - Tunstall, Emma
AU - Turrà, Caterina
AU - Valdes, Yoandy
AU - Valencia Castro, Nelly
AU - Visconti, Guilherme
AU - Vitali, Giordano
AU - Vutikullird, Apinya
AU - Watti, Jezdancher
AU - Werth, Doreen
AU - Wilson, Cheyanne
AU - Wilson, Philippe
AU - Workman, Amy
AU - Wörle, Pamela
AU - Wyen, Christoph
AU - Yamaguchi, Yoshiko
AU - Yamamoto, Kei
PY - 2022
DA - 2022/10/01 00:00:00
PB - Elsevier
SP - 985-996
IS - 10
VL - 10
SN - 2213-2600
SN - 2213-2619
ER -
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@article{2022_MONTGOMERY,
author = {HUGH MONTGOMERY and F.D. Richard Hobbs and Francisco Padilla and Douglas Arbetter and Alison Templeton and Seth Seegobin and KENNETH KIM and Jesus Abraham Simón Campos and Rosalinda H. Arends and Bryan H Brodek and Dennis Brooks and Pedro Garbes and Julieta Jimenez and Gavin C K W Koh and Kelly W. Padilla and Katie Streicher and Rolando M Viani and Vijay Alagappan and Menelas N. Pangalos and Mark T Esser and Wakana Abe and Tania Adan De Varona and Daria Adiatullina and Daniel Aguilar Zapata and Kevin Ahlers and Carolina Aimo and Ayoade Akere and Elena Akimova and Jorge Alatorre Alexander and Logan Aldrich and Ismael Ali Garcia and Karim Ali García and Lee Allison and Rosa Alonso Zuñiga and Ivan Aloysius and Javier Altclas and Andres Alvarisqueta and Martti Antila and Camila Anton and Elisabet Árboix Alamo and Samir Arora and Ramón Alejandro Avilés Felix and Natalya Bakhtina and Varenka Barbero-Becerra and Armando Barragan-Reyes and Alejandro Barreira and Barrett Mitchell and Jiri Beran and Nikolett Berki and Viktoria Berki and Richard Betten and Claudia Binelli and Lenka Brunzová and Cecilia Bussolari and Karianna Byargeon and Justyna Bytnar and Carlos Camberos and Pedro Campos Corzo and Grazia Cannon and Valentina Canovi and Simone Carla da Rosa and Ana Caroline Moser and Luis Carrera Rivas and Marcelo Martin Casas and Paulo Castañeda-Méndez and Ana Cavalcante and Eugenia Cherepova and Alexei Chermenskii and Lauren Clark and Mauro Codeluppi and Flavia Coelho and Belinda Contreras and Alex Cran and Taylor Dao and Chrisette Dharma and Cosimo Di Castri and Victoria Diaz Balocchi and Omar Durán and Kara Earl and Adam Ellery and Tomoko Endo and Andrea Everding and Rainald Fischer and Benedito Fonseca and Chelsea C. Franklin and Susan-Beatrice Franz and Anna Fumagalli and Mauricio Galindo-Amaya and Mariagiulia Galli and Laura Gerna and Karolly Gil Ureña and Henrikki Gomes Antila and Laura Ines Gomes Maricato and Gabriela Goncalvez and Martin Gonzalez and Jesús González-Lama and Stephen Granier and Jacob Granier and Stephan Grunwald and David Guardeño-Ropero and Monica Guberti and Sridhar Guduri and Carolina Guerrero García and Jehad Haggiagi and Kacie Hale and Toshimasa Hayashi and Maiara Hermes and Dante Hernandez Colin and Yuji Hirai and Masayuki Hojo and Tetsuya Homma and Billy Hour and Andreas Huber and Diego Iacovelli and Noriomi Ishibashi and Yutaro Iwabe and Shinyu Izumi and Arne Jessen and Heiko Jessen and Wilner Jeudy and Marta Jiménez Marcos and Rebecca Johnson and Eva Juárez-Hernández and Kiyomi Kabasawa and Katarzyna Kamińska and Megumi Kawabe and Angela Kemp and Oleg Khmelnitskiy and Carina Klassen and Olena Kobrynska and Pavel Koleckar and Stephanie Korn and Marc Kornmann and Viktor Kostenko and Evgenii Kovalchuk and Yana Kovalchuk and Tim Kümmerle and Ulrike Lachmund and Kerstin Lammersmann and Flávio Lastebasse and Ivana Lattuada and Felicitas Lauer and Kyrylo Lebed and Olga Lebed and Diego Lecona-Garcia and Maria Christina Leoni and Marina Lima and Raymond Little and Holly Little and Andrea Lizardi-Díaz and Michele Lobo-Becker and Francesco Luppi and Veronica Macias and Shigefumi MAESAKI and Cristiano Magnaghi and Annalisa Mancini and Stanisław Mazur and Tatiana Melnikova and Sergio Menchaca and Ibrahim Menendez-Perez and Ewa Międlar and Shuuichi Mizunuma and Anastasiya Mochalova and Mihad Mohamed and Theresa Moll and Camila Montalvo and Amber Mottola and Birgit Mück and Rebeca Mussi Brugnolli and Akanksha Nanda and Dörthe Neuner and Agatha Ngwueke and Sebastian Noe and Martin Novacek and Laura Nuzzolo-Shihadeh and Emeka Obiekwe and Isaias G. Ocampo Gaytán and Norio Ohmagari and Shin Ohta and Ptuonye Onyewuchi and Iurii Pankov and Maurício Pedrosa and Yael Peré and Alejandro Pereyra and Eliana Perez and Eduardo Perez-Alba and Paloma Perpiña Lozano and Tanya Perrei and Dena Peterson and Ligia Pierroti and Felipe Pineda-Cárdenas and Teresa Plascencia Sanchez and Camila Poletti and Chiara Pomaranzi and Lisette Portes and Nils Postel and Monica Ramirez and Isabel Ramírez and Miguel Ramirez-Baena and Mahadev Ramjee and Giovanna Ratti and Jackie Reeve and Petr Reichert and Petra Reichertová and Edgar Alejandro Reyes Garcia and Celso Ricardo and Nicomedes Rodríguez Rodríguez and Jaun Roldán Sánchez and Matilde Romero-Lopez and Tyrone Rosales and Harvey Rosales and Mohamed Roshan and Simran Roshan and Patrizia Rovere Querini and Heather Rutter and Sadaf Sachwani and Hironori Sagara and Jun Sakai and Nina Samson and José Héctor Sánchez Mijangos and Liliana Sánchez and Ana Sánchez-González and Micko Sandford and Laura Santana and Felipe Santos de Carvalho and Reiko Sasao and Lubna Sato and Elizabeth Scheuermann and Olaf Schmidt and Masafumi Seki and Safia Shaikh and Daishi Shimada and Masaharu Shinkai and Masahiro Shinoda and Jackie Smith and Fernando Solorzano and Silvia Soncini and Katalin Soregine and Erica Sosa and Olalekan Sowade and Veronika Špinková and Ruth Staniford and Iska Steigemann and Vivien Steiner and Vladimir Strelkov and Cintya R. Suárez Pineda and Hiroki Suenaga and Shintaro Suzaki and Hannah Swayze and Yuji Tada and Yuichiro Takeshita and Yasuo Takiguchi and Akihiko Tanaka and Norihito Tarumoto and Albina Tatarintseva and Michelle Taubert and Elizaveta Terenya and César Tinoco and Tomohiro Tomiyasu and Gladys Torres-Vidal and Gabriela Trejo-Aguiar and Kenji Tsushima and Emma Tunstall and Caterina Turrà and Yoandy Valdes and Nelly Valencia Castro and Guilherme Visconti and Giordano Vitali and Apinya Vutikullird and Jezdancher Watti and Doreen Werth and Cheyanne Wilson and Philippe Wilson and Amy Workman and Pamela Wörle and Christoph Wyen and Yoshiko Yamaguchi and Kei Yamamoto},
title = {Efficacy and safety of intramuscular administration of tixagevimab–cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-controlled trial},
journal = {The Lancet Respiratory Medicine},
year = {2022},
volume = {10},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/S2213-2600(22)00180-1},
number = {10},
pages = {985--996},
doi = {10.1016/S2213-2600(22)00180-1}
}
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MONTGOMERY, HUGH, et al. “Efficacy and safety of intramuscular administration of tixagevimab–cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-controlled trial.” The Lancet Respiratory Medicine, vol. 10, no. 10, Oct. 2022, pp. 985-996. https://doi.org/10.1016/S2213-2600(22)00180-1.