Annual Reports in Medicinal Chemistry, pages 485-515
Metal complexes as G-quadruplex binders
Publication type: Book Chapter
Publication date: 2020-06-29
Quartile SCImago
— Quartile WOS
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Impact factor: —
ISSN: 00657743, 15578437
Abstract
Due to their important biological functions, G-quadruplex (G4) DNA structures have been identified as potential drug targets. Consequently, the interactions of a large number of compounds with G4s and their biological effects have been investigated. While the majority of G4 binders reported to date are based on purely organic molecules, over the past two decades metal complexes have received increasing attention. This chapter provides an overview of metal complexes as G4 binders including a discussion of their properties, in vitro characterization of their affinity and selectivity to G4 structures and cellular studies.
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TY - GENERIC
DO - 10.1016/bs.armc.2020.05.004
UR - https://doi.org/10.1016/bs.armc.2020.05.004
TI - Metal complexes as G-quadruplex binders
T2 - Annual Reports in Medicinal Chemistry
AU - Kench, Tim
AU - Vilar, Ramón
PY - 2020
DA - 2020/06/29
PB - Elsevier
SP - 485-515
SN - 0065-7743
SN - 1557-8437
ER -
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@incollection{2020_Kench,
author = {Tim Kench and Ramón Vilar},
title = {Metal complexes as G-quadruplex binders},
publisher = {Elsevier},
year = {2020},
pages = {485--515},
month = {jun}
}