Studying non-covalent drug–DNA interactions
Sayeed ur Rehman
1
,
Tarique Sarwar
1
,
Mohammed Husain
1
,
Hassan Mubarak Ishqi
1
,
Mohammad TABISH
1
1
Department of Biochemistry, Faculty of Life Sciences, A.M. University, Aligarh, U.P, 202002, India
|
Publication type: Journal Article
Publication date: 2015-06-01
scimago Q1
wos Q2
SJR: 0.912
CiteScore: 6.4
Impact factor: 3.0
ISSN: 00039861, 10960384
PubMed ID:
25951786
Biochemistry
Molecular Biology
Biophysics
Abstract
Drug-DNA interactions have been extensively studied in the recent past. Various techniques have been employed to decipher these interactions. DNA is a major target for a wide range of drugs that may specifically or non-specifically interact with DNA and affect its functions. Interaction between small molecules and DNA are of two types, covalent interactions and non-covalent interactions. Three major modes of non-covalent interactions are electrostatic interactions, groove binding and intercalative binding. This review primarily focuses on discussing various techniques used to study non-covalent interactions that occur between drugs and DNA. Additionally, we report several techniques that may be employed to analyse the binding mode of a drug with DNA. These techniques provide data that are reliable and simple to interpret.
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Metrics
359
Total citations:
359
Citations from 2025:
65
(18.1%)
Cite this
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GOST
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Rehman S. et al. Studying non-covalent drug–DNA interactions // Archives of Biochemistry and Biophysics. 2015. Vol. 576. pp. 49-60.
GOST all authors (up to 50)
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Rehman S., Sarwar T., Husain M., Ishqi H. M., TABISH M. Studying non-covalent drug–DNA interactions // Archives of Biochemistry and Biophysics. 2015. Vol. 576. pp. 49-60.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.abb.2015.03.024
UR - https://doi.org/10.1016/j.abb.2015.03.024
TI - Studying non-covalent drug–DNA interactions
T2 - Archives of Biochemistry and Biophysics
AU - Rehman, Sayeed ur
AU - Sarwar, Tarique
AU - Husain, Mohammed
AU - Ishqi, Hassan Mubarak
AU - TABISH, Mohammad
PY - 2015
DA - 2015/06/01
PB - Elsevier
SP - 49-60
VL - 576
PMID - 25951786
SN - 0003-9861
SN - 1096-0384
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2015_Rehman,
author = {Sayeed ur Rehman and Tarique Sarwar and Mohammed Husain and Hassan Mubarak Ishqi and Mohammad TABISH},
title = {Studying non-covalent drug–DNA interactions},
journal = {Archives of Biochemistry and Biophysics},
year = {2015},
volume = {576},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/j.abb.2015.03.024},
pages = {49--60},
doi = {10.1016/j.abb.2015.03.024}
}