Analytica Chimica Acta, volume 685, issue 1, pages 84-90
Determination of the spectrum of low molecular mass organic acids in urine by capillary electrophoresis with contactless conductivity and ultraviolet photometric detection—An efficient tool for monitoring of inborn metabolic disorders
Publication type: Journal Article
Publication date: 2011-01-01
Journal:
Analytica Chimica Acta
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 6.2
ISSN: 00032670, 18734324
Biochemistry
Spectroscopy
Analytical Chemistry
Environmental Chemistry
Abstract
A mixture of 29 organic acids (OAs) occurring in urine was analyzed by capillary electrophoresis (CE) with capacitively coupled contactless conductivity detection (C(4)D) and UV photometric detection. The optimized analytical system involved a 100 cm long polyacrylamide-coated capillary (50 μm i.d.) and the background electrolyte of 20mM 2-morpholinoethanesulfonic acid (MES)/NaOH+10% (v/v) methanol, pH 6.0 (pH is related to the 20mM MES/NaOH buffer in water). The LOD values obtained by C(4)D for the OAs which do not absorb UV radiation range from 0.6 μM (oxalic acid) to 6.8 μM (pyruvic acid); those obtained by UV photometry for the remaining OAs range from 2.9 μM (5-hydroxy-3-indoleacetic acid) to 10.2 μM (uric acid). The repeatability of the procedure developed is characterized by the coefficients of variation, which vary between 0.3% (tartaric acid) and 0.6% (5-hydroxy-3-indoleacetic acid) for the migration time and between 1.3% (tartaric acid) and 3.5% (lactic acid) for the peak area. The procedure permitted quantitation of 20 OAs in a real urine sample and was applied to monitoring of the occurrence of the inborn metabolic fault of methylmalonic aciduria.
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Tůma P., Samcová E., Stulík K. Determination of the spectrum of low molecular mass organic acids in urine by capillary electrophoresis with contactless conductivity and ultraviolet photometric detection—An efficient tool for monitoring of inborn metabolic disorders // Analytica Chimica Acta. 2011. Vol. 685. No. 1. pp. 84-90.
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Tůma P., Samcová E., Stulík K. Determination of the spectrum of low molecular mass organic acids in urine by capillary electrophoresis with contactless conductivity and ultraviolet photometric detection—An efficient tool for monitoring of inborn metabolic disorders // Analytica Chimica Acta. 2011. Vol. 685. No. 1. pp. 84-90.
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TY - JOUR
DO - 10.1016/j.aca.2010.11.007
UR - https://doi.org/10.1016/j.aca.2010.11.007
TI - Determination of the spectrum of low molecular mass organic acids in urine by capillary electrophoresis with contactless conductivity and ultraviolet photometric detection—An efficient tool for monitoring of inborn metabolic disorders
T2 - Analytica Chimica Acta
AU - Tůma, Petr
AU - Samcová, Eva
AU - Stulík, Karel
PY - 2011
DA - 2011/01/01 00:00:00
PB - Elsevier
SP - 84-90
IS - 1
VL - 685
SN - 0003-2670
SN - 1873-4324
ER -
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@article{2011_Tůma,
author = {Petr Tůma and Eva Samcová and Karel Stulík},
title = {Determination of the spectrum of low molecular mass organic acids in urine by capillary electrophoresis with contactless conductivity and ultraviolet photometric detection—An efficient tool for monitoring of inborn metabolic disorders},
journal = {Analytica Chimica Acta},
year = {2011},
volume = {685},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.aca.2010.11.007},
number = {1},
pages = {84--90},
doi = {10.1016/j.aca.2010.11.007}
}
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MLA
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Tůma, Petr, et al. “Determination of the spectrum of low molecular mass organic acids in urine by capillary electrophoresis with contactless conductivity and ultraviolet photometric detection—An efficient tool for monitoring of inborn metabolic disorders.” Analytica Chimica Acta, vol. 685, no. 1, Jan. 2011, pp. 84-90. https://doi.org/10.1016/j.aca.2010.11.007.