Analytica Chimica Acta, volume 694, issue 1-2, pages 61-66
Study on urinary metabolic profile of phenylketonuria by micellar electrokinetic capillary chromatography with dual electrochemical detection—Potential clinical application in fast diagnosis of phenylketonuria
Publication type: Journal Article
Publication date: 2011-05-01
Journal:
Analytica Chimica Acta
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 6.2
ISSN: 00032670, 18734324
Biochemistry
Spectroscopy
Analytical Chemistry
Environmental Chemistry
Abstract
The urinary metabolic marker compounds, namely phenylpyruvic acid (PPA), 2-hydroxyphenylacetic acid (oOPAA), 4-hydroxyphenylacetic acid (pOPAA), phenyllactic acid (PLA) and phenylacetic acid (PAA) of phenylketonuric individuals were detected by a novel method of micellar electrokinetic capillary chromatography with capacitively coupled contactless conductivity detection and amperometric detection (MECC-C(4)D/AD). Electrophoretic runs were performed in a 35 mmol L(-1) SDS/60 mmol L(-1) H(3)BO(3)-Na(2)B(4)O(7) running buffer (pH 8.2) at a separation voltage of 16 kV, and five marker compounds and the major coexisting compound uric acid (UA) could be well separated within 23 min. Highly linear response was obtained for five marker compounds over three orders of magnitude with detection limits ranging from 6.6×10(-6) to 6.4×10(-8) g mL(-1) (S/N=3). The proposed method has been used to detect the marker compounds simultaneously in urine samples with the advantages of obtaining more information about target analytes and avoiding redundant measurements and high assay cost. Urinary patterns in phenylketonuric babies were distinct and easily distinguished from those of healthy newborns. The proposed MECC-C(4)D/AD method could find clinical application in early noninvasive diagnosis of phenylketonuria (PKU), as significant differences could be found in the urinary content of five marker compounds among the phenylketonuric babies without or with dietotherapy and the healthy babies.
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Zhang D. et al. Study on urinary metabolic profile of phenylketonuria by micellar electrokinetic capillary chromatography with dual electrochemical detection—Potential clinical application in fast diagnosis of phenylketonuria // Analytica Chimica Acta. 2011. Vol. 694. No. 1-2. pp. 61-66.
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Zhang D., Li W., Zhang J., Tang W., Qian C., Feng M., Chu Q., Ye J. Study on urinary metabolic profile of phenylketonuria by micellar electrokinetic capillary chromatography with dual electrochemical detection—Potential clinical application in fast diagnosis of phenylketonuria // Analytica Chimica Acta. 2011. Vol. 694. No. 1-2. pp. 61-66.
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TY - JOUR
DO - 10.1016/j.aca.2011.03.044
UR - https://doi.org/10.1016/j.aca.2011.03.044
TI - Study on urinary metabolic profile of phenylketonuria by micellar electrokinetic capillary chromatography with dual electrochemical detection—Potential clinical application in fast diagnosis of phenylketonuria
T2 - Analytica Chimica Acta
AU - Zhang, Dong-li
AU - Li, Wenli
AU - Zhang, Junbo
AU - Tang, Wanrong
AU - Qian, Chenxu
AU - Feng, Minghao
AU - Chu, Qingcui
AU - Ye, Jiannong
PY - 2011
DA - 2011/05/01 00:00:00
PB - Elsevier
SP - 61-66
IS - 1-2
VL - 694
SN - 0003-2670
SN - 1873-4324
ER -
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@article{2011_Zhang,
author = {Dong-li Zhang and Wenli Li and Junbo Zhang and Wanrong Tang and Chenxu Qian and Minghao Feng and Qingcui Chu and Jiannong Ye},
title = {Study on urinary metabolic profile of phenylketonuria by micellar electrokinetic capillary chromatography with dual electrochemical detection—Potential clinical application in fast diagnosis of phenylketonuria},
journal = {Analytica Chimica Acta},
year = {2011},
volume = {694},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016/j.aca.2011.03.044},
number = {1-2},
pages = {61--66},
doi = {10.1016/j.aca.2011.03.044}
}
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Zhang, Dong-li, et al. “Study on urinary metabolic profile of phenylketonuria by micellar electrokinetic capillary chromatography with dual electrochemical detection—Potential clinical application in fast diagnosis of phenylketonuria.” Analytica Chimica Acta, vol. 694, no. 1-2, May. 2011, pp. 61-66. https://doi.org/10.1016/j.aca.2011.03.044.