Analytica Chimica Acta, volume 1225, pages 340161

Monitoring of biologically active substances in clinical samples by capillary and microchip electrophoresis with contactless conductivity detection: A review

Petr Tůma ¹

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Department of Hygiene, Third Faculty of Medicine, Charles University, Ruská 87, 100 00, Prague, 10, Czech Republic |

Publication type: Journal Article

Publication date: 2022-09-01

Elsevier

Journal: Analytica Chimica Acta

Quartile SCImago

Quartile WOS

Impact factor: 6.2

ISSN: 00032670, 18734324

DOI: 10.1016/j.aca.2022.340161

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Biochemistry

Spectroscopy

Analytical Chemistry

Environmental Chemistry

Abstract

Contactless conductivity detection (C4D) as a universal detection technique plays an important role in combination with efficient electrophoretic separation carried out in capillaries (CE) or on microchips (ME) in the analysis of clinical samples. C4D is particularly sensitive in the quantification of low molecular weight biogenic substances such as inorganic cations and anions, amino acids, amines, low molecular weight organic acids, saccharides and many drugs such as antibiotics, analgesics, anaesthetics or antiepileptics. Biogenic substances are determined in CE/C4D or ME/C4D directly in their native form without derivatization and sample matrix treatment is often based only on dilution or addition of an organic solvent. The limit of detection for most CE/C4D determinations is at the micromolar concentration level, which is sufficient to monitor physiological or therapeutic levels of most of low molecular weight biogenic substances. Therefore, CE/C4D and ME/C4D are widely used for sequential monitoring of nutrients, metabolites and waste products at the level of individual tissues and organs, low-invasive detection of inborn errors of metabolism and cystic fibrosis, pharmacokinetic monitoring and therapeutic drug monitoring. Innovative trends such as electrophoretic stacking, microdialysis, electromembrane extraction, portable and disposable CE instruments and minimally invasive clinical sampling techniques are mentioned. A critical evaluation of the positives and negatives of this technique is presented, covering the main applications published over the last 10 years.

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Microchemical Journal	Microchemical Journal, 5, 11.63% Microchemical Journal 5 publications, 11.63%
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Russian Chemical Reviews	Russian Chemical Reviews, 1, 2.33% Russian Chemical Reviews 1 publication, 2.33%
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Citations by publishers

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Elsevier	Elsevier, 19, 44.19% Elsevier 19 publications, 44.19%
Wiley	Wiley, 5, 11.63% Wiley 5 publications, 11.63%
Springer Nature	Springer Nature, 4, 9.3% Springer Nature 4 publications, 9.3%
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Frontiers Media S.A.	Frontiers Media S.A., 2, 4.65% Frontiers Media S.A. 2 publications, 4.65%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 2, 4.65% Royal Society of Chemistry (RSC) 2 publications, 4.65%
American Chemical Society (ACS)	American Chemical Society (ACS), 2, 4.65% American Chemical Society (ACS) 2 publications, 4.65%
Future Medicine	Future Medicine, 1, 2.33% Future Medicine 1 publication, 2.33%
Japan Society for Analytical Chemistry	Japan Society for Analytical Chemistry, 1, 2.33% Japan Society for Analytical Chemistry 1 publication, 2.33%
King Saud University	King Saud University, 1, 2.33% King Saud University 1 publication, 2.33%
IEEE	IEEE, 1, 2.33% IEEE 1 publication, 2.33%
IOP Publishing	IOP Publishing, 1, 2.33% IOP Publishing 1 publication, 2.33%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 2.33% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 2.33%
	2 4 6 8 10 12 14 16 18 20

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Tůma P. Monitoring of biologically active substances in clinical samples by capillary and microchip electrophoresis with contactless conductivity detection: A review // Analytica Chimica Acta. 2022. Vol. 1225. p. 340161.

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TY - JOUR

DO - 10.1016/j.aca.2022.340161

UR - https://doi.org/10.1016/j.aca.2022.340161

TI - Monitoring of biologically active substances in clinical samples by capillary and microchip electrophoresis with contactless conductivity detection: A review

T2 - Analytica Chimica Acta

AU - Tůma, Petr

PY - 2022

DA - 2022/09/01 00:00:00

PB - Elsevier

SP - 340161

VL - 1225

SN - 0003-2670

SN - 1873-4324

ER -

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@article{2022_Tůma,

author = {Petr Tůma},

title = {Monitoring of biologically active substances in clinical samples by capillary and microchip electrophoresis with contactless conductivity detection: A review},

journal = {Analytica Chimica Acta},

year = {2022},

volume = {1225},

publisher = {Elsevier},

month = {sep},

url = {https://doi.org/10.1016/j.aca.2022.340161},

pages = {340161},

doi = {10.1016/j.aca.2022.340161}

}

Found error?

Publisher

Elsevier

Journal

Analytica Chimica Acta

Quartile SCImago

Quartile WOS

Impact factor

6.2

ISSN

00032670 (Print)
18734324 (Electronic)