Acta Astronautica, volume 195, pages 556-560
The lightweight spherical samplers for simplified collection, storage, and ambient ionization of drugs from saliva and blood
Shamraeva Maria
1
,
Pekov Stanislav
2
,
Bormotov Denis S
1
,
Levin Roman E
1
,
Larina Irina
3
,
Nikolaev Eugene N
2
,
Popov Igor
1
Publication type: Journal Article
Publication date: 2022-06-01
Aerospace Engineering
Abstract
The continuous monitoring of health conditions before, during, and after spaceflight is an important task in gravitational physiology. Thus a simple, non-invasive method for biological samples collection is required, but the specific limitations, such as weight and volume restrictions, limit the variety of suitable samplers. The physiological changes exist at microgravity (μG) conditions and could influence drug pharmacokinetics. Here we present the application of lightweight spherical sampler probes for the simplified sampling of human saliva with further detection of exogenous small molecules by the ambient mass spectrometry. The rigidity and spherical form of the sampler probes allow collecting saliva smears or biological fluids without additional instruments and improve the stability of the ionization process leading to the increased sensitivity of the analysis. The detection and quantitation of acetaminophen, which is used as a model substance, was proved to demonstrate the analytical capabilities of the proposed method to the saliva smears or whole blood samples even after long-term storage at room temperature. The further investigation of drug pharmacokinetic at μG conditions might be provided by means of proposed samplers. • Lightweight spherical samplers substantially simplify the sample collection in the field. • Collected samples do not require special conditions for a long-time storage. • Ambient ionization from porous samples allows sensitive drug quantification.
Citations by journals
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1
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Analytical Science Advances
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Analytical Science Advances
1 publication, 33.33%
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Bulletin of Russian State Medical University
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Bulletin of Russian State Medical University
1 publication, 33.33%
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F1000Research
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F1000Research
1 publication, 33.33%
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1
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Citations by publishers
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1
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Wiley
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Wiley
1 publication, 33.33%
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Pirogov Russian National Research Medical University
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Pirogov Russian National Research Medical University
1 publication, 33.33%
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F1000 Research
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F1000 Research
1 publication, 33.33%
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1
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Shamraeva M. et al. The lightweight spherical samplers for simplified collection, storage, and ambient ionization of drugs from saliva and blood // Acta Astronautica. 2022. Vol. 195. pp. 556-560.
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Shamraeva M., Pekov S., Bormotov D. S., Levin R. E., Larina I., Nikolaev E. N., Popov I. The lightweight spherical samplers for simplified collection, storage, and ambient ionization of drugs from saliva and blood // Acta Astronautica. 2022. Vol. 195. pp. 556-560.
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TY - JOUR
DO - 10.1016/j.actaastro.2022.03.026
UR - https://doi.org/10.1016%2Fj.actaastro.2022.03.026
TI - The lightweight spherical samplers for simplified collection, storage, and ambient ionization of drugs from saliva and blood
T2 - Acta Astronautica
AU - Shamraeva, Maria
AU - Pekov, Stanislav
AU - Bormotov, Denis S
AU - Levin, Roman E
AU - Larina, Irina
AU - Nikolaev, Eugene N
AU - Popov, Igor
PY - 2022
DA - 2022/06/01 00:00:00
PB - Elsevier
SP - 556-560
VL - 195
SN - 0094-5765
ER -
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@article{2022_Shamraeva,
author = {Maria Shamraeva and Stanislav Pekov and Denis S Bormotov and Roman E Levin and Irina Larina and Eugene N Nikolaev and Igor Popov},
title = {The lightweight spherical samplers for simplified collection, storage, and ambient ionization of drugs from saliva and blood},
journal = {Acta Astronautica},
year = {2022},
volume = {195},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016%2Fj.actaastro.2022.03.026},
pages = {556--560},
doi = {10.1016/j.actaastro.2022.03.026}
}