Advanced Drug Delivery Reviews, volume 130, pages 73-89

Harnessing albumin as a carrier for cancer therapies

Hoogenboezem Ella N 1
Duvall Craig L 1
1
 
Department of Biomedical Engineering Vanderbilt University Nashville TN
Publication typeJournal Article
Publication date2018-05-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor16.1
ISSN0169409X, 18728294
Pharmaceutical Science
Abstract
Serum albumin, a natural ligand carrier that is highly concentrated and long-circulating in the blood, has shown remarkable promise as a carrier for anti-cancer agents. Albumin is able to prolong the circulation half-life of otherwise rapidly cleared drugs and, importantly, promote their accumulation within tumors. The applications for using albumin as a cancer drug carrier are broad and include both traditional cancer chemotherapeutics and new classes of biologics. Strategies for leveraging albumin for drug delivery can be classified broadly into exogenous and in situ binding formulations that utilize covalent attachment, non-covalent association, or encapsulation in albumin-based nanoparticles. These methods have shown remarkable preclinical and clinical successes that are examined in this review.

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GOST Copy
Hoogenboezem E. N., Duvall C. L. Harnessing albumin as a carrier for cancer therapies // Advanced Drug Delivery Reviews. 2018. Vol. 130. pp. 73-89.
GOST all authors (up to 50) Copy
Hoogenboezem E. N., Duvall C. L. Harnessing albumin as a carrier for cancer therapies // Advanced Drug Delivery Reviews. 2018. Vol. 130. pp. 73-89.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/j.addr.2018.07.011
UR - https://doi.org/10.1016%2Fj.addr.2018.07.011
TI - Harnessing albumin as a carrier for cancer therapies
T2 - Advanced Drug Delivery Reviews
AU - Hoogenboezem, Ella N
AU - Duvall, Craig L
PY - 2018
DA - 2018/05/01 00:00:00
PB - Elsevier
SP - 73-89
VL - 130
PMID - 30012492
SN - 0169-409X
SN - 1872-8294
ER -
BibTex
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BibTex Copy
@article{2018_Hoogenboezem,
author = {Ella N Hoogenboezem and Craig L Duvall},
title = {Harnessing albumin as a carrier for cancer therapies},
journal = {Advanced Drug Delivery Reviews},
year = {2018},
volume = {130},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016%2Fj.addr.2018.07.011},
pages = {73--89},
doi = {10.1016/j.addr.2018.07.011}
}
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