Open Access
Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications
Publication type: Journal Article
Publication date: 2021-08-01
scimago Q1
wos Q1
SJR: 3.489
CiteScore: 24.3
Impact factor: 14.6
ISSN: 22113835, 22113843
PubMed ID:
34522597
General Pharmacology, Toxicology and Pharmaceutics
Abstract
Pharmaceutical cocrystals are multicomponent systems in which at least one component is an active pharmaceutical ingredient and the others are pharmaceutically acceptable ingredients. Cocrystallization of a drug substance with a coformer is a promising and emerging approach to improve the performance of pharmaceuticals, such as solubility, dissolution profile, pharmacokinetics and stability. This review article presents a comprehensive overview of pharmaceutical cocrystals, including preparation methods, physicochemical properties, and applications. Furthermore, some examples of drug cocrystals are highlighted to illustrate the effect of crystal structures on the various aspects of active pharmaceutical ingredients, such as physical stability, chemical stability, mechanical properties, optical properties, bioavailability, sustained release and therapeutic effect. This review will provide guidance for more efficient design and manufacture of pharmaceutical cocrystals with desired physicochemical properties and applications. Pharmaceutical cocrystals is a promising and emerging approach to modulate the performance of pharmaceuticals, including physical stability, chemical stability, mechanical properties, optical properties, release profiles, bioavailability and therapeutic effect.
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261
Total citations:
261
Citations from 2025:
110
(42.15%)
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GOST
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Guo M. et al. Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications // Acta Pharmaceutica Sinica B. 2021. Vol. 11. No. 8. pp. 2537-2564.
GOST all authors (up to 50)
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Guo M., Sun X., Chen J., Cai T. Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications // Acta Pharmaceutica Sinica B. 2021. Vol. 11. No. 8. pp. 2537-2564.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.apsb.2021.03.030
UR - https://doi.org/10.1016/j.apsb.2021.03.030
TI - Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications
T2 - Acta Pharmaceutica Sinica B
AU - Guo, Minshan
AU - Sun, Xiaojie
AU - Chen, Jiahui
AU - Cai, Ting
PY - 2021
DA - 2021/08/01
PB - Elsevier
SP - 2537-2564
IS - 8
VL - 11
PMID - 34522597
SN - 2211-3835
SN - 2211-3843
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Guo,
author = {Minshan Guo and Xiaojie Sun and Jiahui Chen and Ting Cai},
title = {Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications},
journal = {Acta Pharmaceutica Sinica B},
year = {2021},
volume = {11},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.apsb.2021.03.030},
number = {8},
pages = {2537--2564},
doi = {10.1016/j.apsb.2021.03.030}
}
Cite this
MLA
Copy
Guo, Minshan, et al. “Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications.” Acta Pharmaceutica Sinica B, vol. 11, no. 8, Aug. 2021, pp. 2537-2564. https://doi.org/10.1016/j.apsb.2021.03.030.