Open Access
Research advances in peptide‒drug conjugates
Liming Gong
1
,
Heming Zhao
1
,
Yanhong Liu
1
,
Hao Wu
2
,
Chao Liu
1
,
Shuangyan Chang
1
,
Liqing Chen
1
,
MINGJI JIN
1
,
Qiming Wang
1
,
ZHONGGAO GAO
1
,
Wei Huang
1
2
Department of Pharmacy, Yanbian University, Yanji, Jilin 133000, China
|
Publication type: Journal Article
Publication date: 2023-09-01
scimago Q1
wos Q1
SJR: 3.489
CiteScore: 24.3
Impact factor: 14.6
ISSN: 22113835, 22113843
PubMed ID:
37719380
General Pharmacology, Toxicology and Pharmaceutics
Abstract
Peptide‒drug conjugates (PDCs) are drug delivery systems consisting of a drug covalently coupled to a multifunctional peptide via a cleavable linker. As an emerging prodrug strategy, PDCs not only preserve the function and bioactivity of the peptides but also release the drugs responsively with the cleavable property of the linkers. Given the ability to significantly improve the circulation stability and targeting of drugs in vivo and reduce the toxic side effects of drugs, PDCs have already been extensively applied in drug delivery. Herein, we review the types and mechanisms of peptides, linkers and drugs used to construct PDCs, and summarize the clinical applications and challenges of PDC drugs.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
4
5
6
|
|
|
Acta Pharmaceutica Sinica B
6 publications, 7.32%
|
|
|
European Journal of Medicinal Chemistry
5 publications, 6.1%
|
|
|
Molecular Pharmaceutics
3 publications, 3.66%
|
|
|
Journal of Medicinal Chemistry
3 publications, 3.66%
|
|
|
International Journal of Pharmaceutics
3 publications, 3.66%
|
|
|
Advanced Science
2 publications, 2.44%
|
|
|
Journal of Controlled Release
2 publications, 2.44%
|
|
|
Bioorganic Chemistry
2 publications, 2.44%
|
|
|
Pharmaceutics
2 publications, 2.44%
|
|
|
Chinese Chemical Letters
2 publications, 2.44%
|
|
|
ACS applied materials & interfaces
2 publications, 2.44%
|
|
|
Inorganic Chemistry
1 publication, 1.22%
|
|
|
ChemBioChem
1 publication, 1.22%
|
|
|
ACS Pharmacology & Translational Science
1 publication, 1.22%
|
|
|
International Journal of Biological Macromolecules
1 publication, 1.22%
|
|
|
Heliyon
1 publication, 1.22%
|
|
|
Frontiers in Nutrition
1 publication, 1.22%
|
|
|
Dalton Transactions
1 publication, 1.22%
|
|
|
Tetrahedron Letters
1 publication, 1.22%
|
|
|
Medicinal Research Reviews
1 publication, 1.22%
|
|
|
Inorganic Chemistry Frontiers
1 publication, 1.22%
|
|
|
Nano Today
1 publication, 1.22%
|
|
|
Pharmaceutical Science Advances
1 publication, 1.22%
|
|
|
Nucleic Acids Research
1 publication, 1.22%
|
|
|
Chemical Science
1 publication, 1.22%
|
|
|
ChemMedChem
1 publication, 1.22%
|
|
|
European Journal of Organic Chemistry
1 publication, 1.22%
|
|
|
Free Radical Biology and Medicine
1 publication, 1.22%
|
|
|
Investigational New Drugs
1 publication, 1.22%
|
|
|
1
2
3
4
5
6
|
Publishers
|
5
10
15
20
25
30
35
|
|
|
Elsevier
34 publications, 41.46%
|
|
|
Wiley
13 publications, 15.85%
|
|
|
American Chemical Society (ACS)
12 publications, 14.63%
|
|
|
Springer Nature
6 publications, 7.32%
|
|
|
MDPI
4 publications, 4.88%
|
|
|
Frontiers Media S.A.
3 publications, 3.66%
|
|
|
Royal Society of Chemistry (RSC)
3 publications, 3.66%
|
|
|
Oxford University Press
1 publication, 1.22%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 publication, 1.22%
|
|
|
Ovid Technologies (Wolters Kluwer Health)
1 publication, 1.22%
|
|
|
Taylor & Francis
1 publication, 1.22%
|
|
|
American Association for the Advancement of Science (AAAS)
1 publication, 1.22%
|
|
|
Science in China Press
1 publication, 1.22%
|
|
|
Bentham Science Publishers Ltd.
1 publication, 1.22%
|
|
|
5
10
15
20
25
30
35
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
82
Total citations:
82
Citations from 2025:
47
(57.32%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Gong L. et al. Research advances in peptide‒drug conjugates // Acta Pharmaceutica Sinica B. 2023. Vol. 13. No. 9. pp. 3659-3677.
GOST all authors (up to 50)
Copy
Gong L., Zhao H., Liu Y., Wu H., Liu C., Chang S., Chen L., JIN M., Wang Q., GAO Z., Huang W. Research advances in peptide‒drug conjugates // Acta Pharmaceutica Sinica B. 2023. Vol. 13. No. 9. pp. 3659-3677.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.apsb.2023.02.013
UR - https://doi.org/10.1016/j.apsb.2023.02.013
TI - Research advances in peptide‒drug conjugates
T2 - Acta Pharmaceutica Sinica B
AU - Gong, Liming
AU - Zhao, Heming
AU - Liu, Yanhong
AU - Wu, Hao
AU - Liu, Chao
AU - Chang, Shuangyan
AU - Chen, Liqing
AU - JIN, MINGJI
AU - Wang, Qiming
AU - GAO, ZHONGGAO
AU - Huang, Wei
PY - 2023
DA - 2023/09/01
PB - Elsevier
SP - 3659-3677
IS - 9
VL - 13
PMID - 37719380
SN - 2211-3835
SN - 2211-3843
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2023_Gong,
author = {Liming Gong and Heming Zhao and Yanhong Liu and Hao Wu and Chao Liu and Shuangyan Chang and Liqing Chen and MINGJI JIN and Qiming Wang and ZHONGGAO GAO and Wei Huang},
title = {Research advances in peptide‒drug conjugates},
journal = {Acta Pharmaceutica Sinica B},
year = {2023},
volume = {13},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/j.apsb.2023.02.013},
number = {9},
pages = {3659--3677},
doi = {10.1016/j.apsb.2023.02.013}
}
Cite this
MLA
Copy
Gong, Liming, et al. “Research advances in peptide‒drug conjugates.” Acta Pharmaceutica Sinica B, vol. 13, no. 9, Sep. 2023, pp. 3659-3677. https://doi.org/10.1016/j.apsb.2023.02.013.