Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, volume 1839, issue 5, pages 387-394
Breaking new ground: Digging into TERRA function
Publication type: Journal Article
Publication date: 2014-05-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 4.7
ISSN: 18749399, 18764320
Biochemistry
Molecular Biology
Genetics
Structural Biology
Biophysics
Abstract
Despite the fact that telomeres carry chromatin marks typically associated with silent heterochromatin, they are actively transcribed into TElomeric Repeat containing RNA (TERRA). TERRA transcription is conserved from yeast to man, initiates in the subtelomeric region and proceeds through the telomeric tract of presumably each individual telomere. TERRA levels are increased in yeast survivors and in cancer cells employing ALT as a telomere maintenance mechanism (TMM). Thus, TERRA may be a promising biomarker and potential target in anti-cancer therapy. Interestingly, several recent publications implicate TERRA in regulatory processes including telomere end protection and the establishment of the heterochromatic state at telomeres. A picture is emerging whereby TERRA acts as a regulator of telomere length and hence the associated onset of replicative senescence in a cell. In this review we will summarize the latest results regarding TERRA transcription, localization and related function. A special focus will be set on the potential role of TERRA in the regulation of telomere length and replicative senescence. Possible implications of increased TERRA levels in yeast survivors and in ALT cancer cells will be discussed.
Citations by journals
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Citations by publishers
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7 publications, 24.14%
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2 publications, 6.9%
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1 publication, 3.45%
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Impact Journals
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1 publication, 3.45%
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SAGE
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SAGE
1 publication, 3.45%
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Springer Nature
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Springer Nature
1 publication, 3.45%
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Society for the Study of Reproduction
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1 publication, 3.45%
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Walter de Gruyter
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Walter de Gruyter
1 publication, 3.45%
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Proceedings of the National Academy of Sciences (PNAS)
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Proceedings of the National Academy of Sciences (PNAS)
1 publication, 3.45%
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Cold Spring Harbor Laboratory
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Cold Spring Harbor Laboratory
1 publication, 3.45%
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Sociedade Brasileira de Genetica
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Sociedade Brasileira de Genetica, 1, 3.45%
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1 publication, 3.45%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Maicher A., Lockhart A., Luke B. Breaking new ground: Digging into TERRA function // Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 2014. Vol. 1839. No. 5. pp. 387-394.
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Maicher A., Lockhart A., Luke B. Breaking new ground: Digging into TERRA function // Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 2014. Vol. 1839. No. 5. pp. 387-394.
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TY - JOUR
DO - 10.1016/j.bbagrm.2014.03.012
UR - https://doi.org/10.1016%2Fj.bbagrm.2014.03.012
TI - Breaking new ground: Digging into TERRA function
T2 - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
AU - Maicher, André
AU - Lockhart, Arianna
AU - Luke, Brian
PY - 2014
DA - 2014/05/01 00:00:00
PB - Elsevier
SP - 387-394
IS - 5
VL - 1839
SN - 1874-9399
SN - 1876-4320
ER -
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@article{2014_Maicher,
author = {André Maicher and Arianna Lockhart and Brian Luke},
title = {Breaking new ground: Digging into TERRA function},
journal = {Biochimica et Biophysica Acta - Gene Regulatory Mechanisms},
year = {2014},
volume = {1839},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016%2Fj.bbagrm.2014.03.012},
number = {5},
pages = {387--394},
doi = {10.1016/j.bbagrm.2014.03.012}
}
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Maicher, André, et al. “Breaking new ground: Digging into TERRA function.” Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, vol. 1839, no. 5, May. 2014, pp. 387-394. https://doi.org/10.1016%2Fj.bbagrm.2014.03.012.