Nitrosporeusine A attenuates sepsis-associated acute kidney injury through the downregulation of IL-6/sIL-6R axis activation-mediated PGC-1α suppression
Publication type: Journal Article
Publication date: 2019-07-01
scimago Q2
wos Q3
SJR: 0.748
CiteScore: 4.9
Impact factor: 2.2
ISSN: 0006291X, 10902104
PubMed ID:
31164200
Biochemistry
Molecular Biology
Cell Biology
Biophysics
Abstract
Nitrosporeusine A (NA) has been recently reported to exert anti-inflammatory and renal protective effects, but whether NA can attenuate sepsis-associated acute kidney injury (AKI) has not yet been reported. In this study, our results found that cecal ligation and puncture (CLP) reduced renal PGC-1α expression and induced oxidative stress in C57BL/6 mice. PGC-1α overexpression attenuated CLP-induced AKI with decreased oxidative stress, whereas worsened AKI with excessive reactive oxygen species (ROS) production was observed in renal specific PGC-1α knockout (NiPKO) mice. In addition, PGC-1α expression is retained in IL-6-/- mice and wild-type (WT) C57BL/6 mice received JAK2/STAT3 inhibition. Finally, administration of NA attenuated CLP-induced AKI with decreased IL-6/sIL-6R axis activation, increased PGC-1α expression, and diminished ROS production in injured kidneys. However, NA failed to attenuate CLP-induced AKI in NiPKO mice. Together, these results suggested that NA attenuates sepsis-associated AKI through the downregulation of IL-6/sIL-6R axis activation-mediated renal PGC-1α suppression.
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Citations from 2025:
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GOST
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Zhao Y. et al. Nitrosporeusine A attenuates sepsis-associated acute kidney injury through the downregulation of IL-6/sIL-6R axis activation-mediated PGC-1α suppression // Biochemical and Biophysical Research Communications. 2019. Vol. 515. No. 3. pp. 474-480.
GOST all authors (up to 50)
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Zhao Y., Nie M., Xu P., Li H., Xu L., Cheng X., Lei Y. Q. Nitrosporeusine A attenuates sepsis-associated acute kidney injury through the downregulation of IL-6/sIL-6R axis activation-mediated PGC-1α suppression // Biochemical and Biophysical Research Communications. 2019. Vol. 515. No. 3. pp. 474-480.
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RIS
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TY - JOUR
DO - 10.1016/j.bbrc.2019.05.151
UR - https://doi.org/10.1016/j.bbrc.2019.05.151
TI - Nitrosporeusine A attenuates sepsis-associated acute kidney injury through the downregulation of IL-6/sIL-6R axis activation-mediated PGC-1α suppression
T2 - Biochemical and Biophysical Research Communications
AU - Zhao, Yan
AU - Nie, Ming
AU - Xu, Peng
AU - Li, Hua
AU - Xu, Lei
AU - Cheng, Xue-Qi
AU - Lei, Yan Qing
PY - 2019
DA - 2019/07/01
PB - Elsevier
SP - 474-480
IS - 3
VL - 515
PMID - 31164200
SN - 0006-291X
SN - 1090-2104
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Zhao,
author = {Yan Zhao and Ming Nie and Peng Xu and Hua Li and Lei Xu and Xue-Qi Cheng and Yan Qing Lei},
title = {Nitrosporeusine A attenuates sepsis-associated acute kidney injury through the downregulation of IL-6/sIL-6R axis activation-mediated PGC-1α suppression},
journal = {Biochemical and Biophysical Research Communications},
year = {2019},
volume = {515},
publisher = {Elsevier},
month = {jul},
url = {https://doi.org/10.1016/j.bbrc.2019.05.151},
number = {3},
pages = {474--480},
doi = {10.1016/j.bbrc.2019.05.151}
}
Cite this
MLA
Copy
Zhao, Yan, et al. “Nitrosporeusine A attenuates sepsis-associated acute kidney injury through the downregulation of IL-6/sIL-6R axis activation-mediated PGC-1α suppression.” Biochemical and Biophysical Research Communications, vol. 515, no. 3, Jul. 2019, pp. 474-480. https://doi.org/10.1016/j.bbrc.2019.05.151.