,
volume 23
,
issue 4
,
pages 479-486
Mechanism of action of inhibitors of dipeptidyl-peptidase-4 (DPP-4)
1
Department of Metabolic Disorders, Merck Research Laboratories, P. O. Box 2000, Rahway, NJ 07065, USA.
|
Publication type: Journal Article
Publication date: 2009-08-01
scimago Q1
wos Q1
SJR: 2.007
CiteScore: 12.4
Impact factor: 6.1
ISSN: 1521690X, 15321908
PubMed ID:
19748065
Endocrinology
Endocrinology, Diabetes and Metabolism
Abstract
Dipeptidyl-peptidase IV (DPP-4) inhibitors inhibit the degradation of the incretins, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). The first available DPP-4 inhibitors are sitagliptin and vildagliptin. These compounds are orally active and have been shown to be efficacious and well tolerated. Two additional DPP-4 inhibitors are under review, and there are several others in clinical development. This article gives an overview on the mechanism of action of DPP-4 inhibitors and focuses on their development and their important physiological actions with regard to the treatment of type 2 diabetes.
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Citations from 2024:
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THORNBERRY N. A., Gallwitz B. Mechanism of action of inhibitors of dipeptidyl-peptidase-4 (DPP-4) // Best Practice and Research in Clinical Endocrinology and Metabolism. 2009. Vol. 23. No. 4. pp. 479-486.
GOST all authors (up to 50)
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THORNBERRY N. A., Gallwitz B. Mechanism of action of inhibitors of dipeptidyl-peptidase-4 (DPP-4) // Best Practice and Research in Clinical Endocrinology and Metabolism. 2009. Vol. 23. No. 4. pp. 479-486.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.beem.2009.03.004
UR - https://doi.org/10.1016/j.beem.2009.03.004
TI - Mechanism of action of inhibitors of dipeptidyl-peptidase-4 (DPP-4)
T2 - Best Practice and Research in Clinical Endocrinology and Metabolism
AU - THORNBERRY, Nancy A.
AU - Gallwitz, Baptist
PY - 2009
DA - 2009/08/01
PB - Elsevier
SP - 479-486
IS - 4
VL - 23
PMID - 19748065
SN - 1521-690X
SN - 1532-1908
ER -
Cite this
BibTex (up to 50 authors)
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@article{2009_THORNBERRY,
author = {Nancy A. THORNBERRY and Baptist Gallwitz},
title = {Mechanism of action of inhibitors of dipeptidyl-peptidase-4 (DPP-4)},
journal = {Best Practice and Research in Clinical Endocrinology and Metabolism},
year = {2009},
volume = {23},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.beem.2009.03.004},
number = {4},
pages = {479--486},
doi = {10.1016/j.beem.2009.03.004}
}
Cite this
MLA
Copy
THORNBERRY, Nancy A., and Baptist Gallwitz. “Mechanism of action of inhibitors of dipeptidyl-peptidase-4 (DPP-4).” Best Practice and Research in Clinical Endocrinology and Metabolism, vol. 23, no. 4, Aug. 2009, pp. 479-486. https://doi.org/10.1016/j.beem.2009.03.004.