Substituted phosphonic analogues of phenylglycine as inhibitors of phenylalanine ammonia lyase from potatoes
Weronika Wanat
1, 2, 3, 4
,
Michał Talma
1, 2, 3, 4
,
Józef Hurek
5
,
Małgorzata Pawełczak
5
,
P Kafarski
1, 2, 3, 4
1
Department of Bioorganic Chemistry
2
Faculty of Chemistry
4
Wybrzeże Wyspianskiego 27 50-370 Wrocław Poland
|
Publication type: Journal Article
Publication date: 2018-08-01
scimago Q2
wos Q3
SJR: 0.884
CiteScore: 6.0
Impact factor: 3.0
ISSN: 03009084, 61831638, 16386183
PubMed ID:
29890205
Biochemistry
General Medicine
Abstract
A series of phosphonic acid analogues of phenylglycine variously substituted in phenyl ring have been synthesized and evaluated for their inhibitory activity towards potato l-phenylalanine ammonia lyase. Most of the compounds appeared to act as moderate (micromolar) inhibitors of the enzyme. Analysis of their binding performed using molecular modeling have shown that they might be bound either in active site of the enzyme or in the non-physiologic site. The latter one is located in adjoining deep site nearby the to the entrance channel for substrate into active site.
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11
Total citations:
11
Citations from 2025:
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(45.45%)
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GOST
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Wanat W. et al. Substituted phosphonic analogues of phenylglycine as inhibitors of phenylalanine ammonia lyase from potatoes // Biochimie. 2018. Vol. 151. pp. 119-127.
GOST all authors (up to 50)
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Wanat W., Talma M., Hurek J., Pawełczak M., Kafarski P. Substituted phosphonic analogues of phenylglycine as inhibitors of phenylalanine ammonia lyase from potatoes // Biochimie. 2018. Vol. 151. pp. 119-127.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.biochi.2018.06.005
UR - https://doi.org/10.1016/j.biochi.2018.06.005
TI - Substituted phosphonic analogues of phenylglycine as inhibitors of phenylalanine ammonia lyase from potatoes
T2 - Biochimie
AU - Wanat, Weronika
AU - Talma, Michał
AU - Hurek, Józef
AU - Pawełczak, Małgorzata
AU - Kafarski, P
PY - 2018
DA - 2018/08/01
PB - Elsevier
SP - 119-127
VL - 151
PMID - 29890205
SN - 0300-9084
SN - 6183-1638
SN - 1638-6183
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Wanat,
author = {Weronika Wanat and Michał Talma and Józef Hurek and Małgorzata Pawełczak and P Kafarski},
title = {Substituted phosphonic analogues of phenylglycine as inhibitors of phenylalanine ammonia lyase from potatoes},
journal = {Biochimie},
year = {2018},
volume = {151},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.biochi.2018.06.005},
pages = {119--127},
doi = {10.1016/j.biochi.2018.06.005}
}