Interaction Of 5-Substituted Pyrimidine Nucleoside Analogues And M.Tuberculosis: A View Through An Electron Microscope.
Elena Matyugina
1
,
Vasiliy A Kezin
1
,
Sofya N Andreevskaya
2
,
Olga G. Leonova
1
,
Liudmila A Alexandrova
1
,
Larisa Chernousova
2
,
Tatiana Smirnova
2
,
В. И. Попенко
1
,
Тип публикации: Journal Article
Дата публикации: 2020-04-01
scimago Q2
wos Q3
БС2
SJR: 0.884
CiteScore: 6.0
Impact factor: 3.0
ISSN: 03009084, 61831638, 16386183
PubMed ID:
32147512
Biochemistry
General Medicine
Краткое описание
The data of transmission electron microscopy (TEM) on morphology of M. tuberculosis H37Rv bacterial cells treated with four analogues of pyrimidine nucleosides with different substituents at 5 position of base are presented. We showed that the growth of M. tuberculosis H37Rv cells effectively inhibited by each of these compounds. This process is accompanied with the accumulation of lipid intracellular vacuole-like inclusions in the cells, appearance of deep protrusions and indentations on the surface, partial and/or complete destruction of the three-layered cell envelope. The exact molecular mechanism of action of 5-substituted pyrimidine nucleosides on M. tuberculosis cells remains to be proved. However, one can suggest that mechanism of action for these compounds is related either to their direct interactions with bacteria cell walls or to interactions with enzymes participating in the process of cell wall formation.
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Khandazhinskaya A. et al. Interaction Of 5-Substituted Pyrimidine Nucleoside Analogues And M.Tuberculosis: A View Through An Electron Microscope. // Biochimie. 2020. Vol. 171-172. pp. 170-177.
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Khandazhinskaya A., Matyugina E., Kezin V. A., Andreevskaya S. N., Leonova O. G., Alexandrova L. A., Chernousova L., Smirnova T., Попенко В. И., Кочетков С. Н. Interaction Of 5-Substituted Pyrimidine Nucleoside Analogues And M.Tuberculosis: A View Through An Electron Microscope. // Biochimie. 2020. Vol. 171-172. pp. 170-177.
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TY - JOUR
DO - 10.1016/j.biochi.2020.03.004
UR - https://doi.org/10.1016/j.biochi.2020.03.004
TI - Interaction Of 5-Substituted Pyrimidine Nucleoside Analogues And M.Tuberculosis: A View Through An Electron Microscope.
T2 - Biochimie
AU - Khandazhinskaya, Anastasia
AU - Matyugina, Elena
AU - Kezin, Vasiliy A
AU - Andreevskaya, Sofya N
AU - Leonova, Olga G.
AU - Alexandrova, Liudmila A
AU - Chernousova, Larisa
AU - Smirnova, Tatiana
AU - Попенко, В. И.
AU - Кочетков, С. Н.
PY - 2020
DA - 2020/04/01
PB - Elsevier
SP - 170-177
VL - 171-172
PMID - 32147512
SN - 0300-9084
SN - 6183-1638
SN - 1638-6183
ER -
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@article{2020_Khandazhinskaya,
author = {Anastasia Khandazhinskaya and Elena Matyugina and Vasiliy A Kezin and Sofya N Andreevskaya and Olga G. Leonova and Liudmila A Alexandrova and Larisa Chernousova and Tatiana Smirnova and В. И. Попенко and С. Н. Кочетков},
title = {Interaction Of 5-Substituted Pyrimidine Nucleoside Analogues And M.Tuberculosis: A View Through An Electron Microscope.},
journal = {Biochimie},
year = {2020},
volume = {171-172},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016/j.biochi.2020.03.004},
pages = {170--177},
doi = {10.1016/j.biochi.2020.03.004}
}
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