Biochimie, volume 204, pages 136-139
Mitochondrial peptide Mtln contributes to oxidative metabolism in mice
Averina Olga A.
1
,
Permyakov Oleg A
1
,
Emelianova Mariia A
2
,
Grigoryeva Olga O
1
,
Gulyaev Mikhail
3
,
Pavlova Olga S
3
,
Mariasina Sofia
1
,
Frolova Olga Yu
4
,
Kurkina Marina V
5
,
Baydakova Galina
5
,
Zakharova A. Yu.
5
,
Marey Maria V
6
,
Tsarev Dmitry A
4
,
Tashlitsky Vadim N
7
,
Popov Vladimir
3
,
Lovat Maxim L.
4, 8
,
VYSSOKIKH Mikhail Yu
6, 8
,
Sergiev Petr V.
1, 2
Publication type: Journal Article
Publication date: 2023-01-01
Biochemistry
General Medicine
Abstract
Mitoregulin (Mtln) is a recently identified 56 amino acid long mitochondrial peptide conserved in vertebrates. Mtln is known to enhance function of respiratory complex I, which is likely mediated by modulation of lipid composition. To address an influence of Mtln gene on the metabolism we created knockout mice deficient in Mtln gene. In line with accumulation of triglycerides observed earlier on a model of Mtln knockout cell lines, we observed Mtln KO mice to develop obesity on a high fat diet. An increased weight gain could be attributed to enhanced fat accumulation according to the magnetic resonance live imaging. In addition, Mtln KO mice demonstrate elevated serum triglycerides and other oxidation substrates accompanied by an exhaustion of tricarboxylic acids cycle intermediates, suggesting suboptimal oxidation of respiration substrates by mitochondria lacking Mtln.
Citations by journals
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
2 publications, 25%
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iScience
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iScience
2 publications, 25%
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Redox Biology
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Redox Biology
1 publication, 12.5%
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Biochemical and Biophysical Research Communications
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Biochemical and Biophysical Research Communications
1 publication, 12.5%
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Journal of Inflammation Research
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Journal of Inflammation Research
1 publication, 12.5%
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Journal of Physiology
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Journal of Physiology
1 publication, 12.5%
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1
2
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Citations by publishers
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1
2
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4
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Elsevier
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Elsevier
4 publications, 50%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 25%
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Dove Medical Press
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Dove Medical Press
1 publication, 12.5%
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Wiley
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Wiley
1 publication, 12.5%
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1
2
3
4
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Averina O. A. et al. Mitochondrial peptide Mtln contributes to oxidative metabolism in mice // Biochimie. 2023. Vol. 204. pp. 136-139.
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Averina O. A., Permyakov O. A., Emelianova M. A., Grigoryeva O. O., Gulyaev M., Pavlova O. S., Mariasina S., Frolova O. Yu., Kurkina M. V., Baydakova G., Zakharova A. Y., Marey M. V., Tsarev D. A., Tashlitsky V. N., Popov V., Lovat M. L., Polshakov V. I., VYSSOKIKH M. Yu., Sergiev P. V. Mitochondrial peptide Mtln contributes to oxidative metabolism in mice // Biochimie. 2023. Vol. 204. pp. 136-139.
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TY - JOUR
DO - 10.1016/j.biochi.2022.09.009
UR - https://doi.org/10.1016%2Fj.biochi.2022.09.009
TI - Mitochondrial peptide Mtln contributes to oxidative metabolism in mice
T2 - Biochimie
AU - Averina, Olga A.
AU - Permyakov, Oleg A
AU - Emelianova, Mariia A
AU - Grigoryeva, Olga O
AU - Gulyaev, Mikhail
AU - Pavlova, Olga S
AU - Mariasina, Sofia
AU - Frolova, Olga Yu
AU - Kurkina, Marina V
AU - Baydakova, Galina
AU - Zakharova, A. Yu.
AU - Marey, Maria V
AU - Tsarev, Dmitry A
AU - Tashlitsky, Vadim N
AU - Popov, Vladimir
AU - Lovat, Maxim L.
AU - Polshakov, Vladimir I.
AU - VYSSOKIKH, Mikhail Yu
AU - Sergiev, Petr V.
PY - 2023
DA - 2023/01/01 00:00:00
PB - Elsevier
SP - 136-139
VL - 204
SN - 0300-9084
SN - 6183-1638
ER -
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@article{2023_Averina,
author = {Olga A. Averina and Oleg A Permyakov and Mariia A Emelianova and Olga O Grigoryeva and Mikhail Gulyaev and Olga S Pavlova and Sofia Mariasina and Olga Yu Frolova and Marina V Kurkina and Galina Baydakova and A. Yu. Zakharova and Maria V Marey and Dmitry A Tsarev and Vadim N Tashlitsky and Vladimir Popov and Maxim L. Lovat and Vladimir I. Polshakov and Mikhail Yu VYSSOKIKH and Petr V. Sergiev},
title = {Mitochondrial peptide Mtln contributes to oxidative metabolism in mice},
journal = {Biochimie},
year = {2023},
volume = {204},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016%2Fj.biochi.2022.09.009},
pages = {136--139},
doi = {10.1016/j.biochi.2022.09.009}
}