In vitro antileishmanial properties of new flavonoids against Leishmania donovani
Publication type: Journal Article
Publication date: 2011-07-01
Food Science
Abstract
This study focuses on the in vitro antileishmanial evaluation of twenty original flavones which differ in substituent of the A-ring, mainly at C-7, and in substitution pattern of the lateral B-ring against Leishmania donovani. Flavonoids were evaluated in vitro against L. donovani promastigotes wild-type and drug-resistant lines using the MTT test and against intramacrophage amastigotes using a reporter gene luciferase assay. Cytotoxicity was evaluated on KB cell line. The most active compounds 7, 11 and 14, showed IC50 values on the intramacrophage amastigotes in a range from 1.7 to 3.6 μM with a selective index 29.9 for compound 14. Compound 14 being about 6-fold more active than miltefosine on this L. donovani intramacrophage amastigote model, it is proposed for a further in vivo evaluation.
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GOST
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Lewin G. et al. In vitro antileishmanial properties of new flavonoids against Leishmania donovani // Biomedicine & Preventive Nutrition. 2011. Vol. 1. No. 3. pp. 168-171.
GOST all authors (up to 50)
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Lewin G., Cojean S., Gupta S. R., Verma A., PURI S., Loiseau P. M. In vitro antileishmanial properties of new flavonoids against Leishmania donovani // Biomedicine & Preventive Nutrition. 2011. Vol. 1. No. 3. pp. 168-171.
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RIS
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TY - JOUR
DO - 10.1016/j.bionut.2011.06.012
UR - https://doi.org/10.1016/j.bionut.2011.06.012
TI - In vitro antileishmanial properties of new flavonoids against Leishmania donovani
T2 - Biomedicine & Preventive Nutrition
AU - Lewin, G.
AU - Cojean, S.
AU - Gupta, S. R.
AU - Verma, A.
AU - PURI, S.K.
AU - Loiseau, Philippe M.
PY - 2011
DA - 2011/07/01
PB - Elsevier
SP - 168-171
IS - 3
VL - 1
SN - 2210-5239
ER -
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BibTex (up to 50 authors)
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@article{2011_Lewin,
author = {G. Lewin and S. Cojean and S. R. Gupta and A. Verma and S.K. PURI and Philippe M. Loiseau},
title = {In vitro antileishmanial properties of new flavonoids against Leishmania donovani},
journal = {Biomedicine & Preventive Nutrition},
year = {2011},
volume = {1},
publisher = {Elsevier},
month = {jul},
url = {https://doi.org/10.1016/j.bionut.2011.06.012},
number = {3},
pages = {168--171},
doi = {10.1016/j.bionut.2011.06.012}
}
Cite this
MLA
Copy
Lewin, G., et al. “In vitro antileishmanial properties of new flavonoids against Leishmania donovani.” Biomedicine & Preventive Nutrition, vol. 1, no. 3, Jul. 2011, pp. 168-171. https://doi.org/10.1016/j.bionut.2011.06.012.