Tick-borne flavivirus reproduction inhibitors based on isoxazole core linked with adamantane.
Evgenia Dueva
2, 3
,
Liubov I. Kozlovskaya
4, 5
,
Nikolay A Zefirov
2, 6
,
Yuri Grishin
1
,
Gennady M. Butov
7
,
V. A. Palyulin
2, 6
,
Tamara S. Kuznetsova
1
,
Galina G. Karganova
4, 5
,
Olga N Zefirova
2, 6
,
Dmitry I. Osolodkin
2, 8
,
Тип публикации: Journal Article
Дата публикации: 2019-06-01
scimago Q1
wos Q1
БС1
SJR: 0.786
CiteScore: 8.3
Impact factor: 4.7
ISSN: 00452068, 10902120
PubMed ID:
30947098
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Краткое описание
Infections caused by flaviviruses pose a huge threat for public health all over the world. The search for therapeutically relevant compounds targeting tick-borne flaviviruses requires the exploration of novel chemotypes. In the present work a large series of novel polyfunctionalized isoxazole derivatives bearing substituents with various steric and electronic effects was obtained by our unique versatile synthetic procedure and their antiviral activity against tick-borne encephalitis, Omsk hemorrhagic fever, and Powassan viruses was studied in vitro. The majority of studied isoxazoles showed activity in low micromolar range. No appreciable cytotoxicity was observed for tested compounds. The lead compounds, 5-aminoisoxazole derivatives containing adamantyl moiety, exhibited strong antiviral activity and excellent therapeutic index.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Топ-30
Журналы
|
1
2
3
|
|
|
Archiv der Pharmazie
3 публикации, 10.71%
|
|
|
International Journal of Molecular Sciences
3 публикации, 10.71%
|
|
|
Journal of General Virology
1 публикация, 3.57%
|
|
|
Organic and Biomolecular Chemistry
1 публикация, 3.57%
|
|
|
Molecules
1 публикация, 3.57%
|
|
|
Viruses
1 публикация, 3.57%
|
|
|
Chemistry of Heterocyclic Compounds
1 публикация, 3.57%
|
|
|
Mendeleev Communications
1 публикация, 3.57%
|
|
|
Antiviral Research
1 публикация, 3.57%
|
|
|
European Journal of Medicinal Chemistry
1 публикация, 3.57%
|
|
|
Asian Journal of Organic Chemistry
1 публикация, 3.57%
|
|
|
Journal of Medicinal Chemistry
1 публикация, 3.57%
|
|
|
ChemistrySelect
1 публикация, 3.57%
|
|
|
Kuban Scientific Medical Bulletin
1 публикация, 3.57%
|
|
|
Annual Reports in Medicinal Chemistry
1 публикация, 3.57%
|
|
|
Synthesis
1 публикация, 3.57%
|
|
|
Vaccines
1 публикация, 3.57%
|
|
|
Bioorganic and Medicinal Chemistry
1 публикация, 3.57%
|
|
|
Chemical Biology and Drug Design
1 публикация, 3.57%
|
|
|
Russian Chemical Bulletin
1 публикация, 3.57%
|
|
|
Russian Chemical Reviews
1 публикация, 3.57%
|
|
|
Infectious Diseases & Immunity
1 публикация, 3.57%
|
|
|
Molecular Diversity
1 публикация, 3.57%
|
|
|
1
2
3
|
Издатели
|
1
2
3
4
5
6
|
|
|
Wiley
6 публикаций, 21.43%
|
|
|
MDPI
6 публикаций, 21.43%
|
|
|
Elsevier
5 публикаций, 17.86%
|
|
|
Springer Nature
3 публикации, 10.71%
|
|
|
Microbiology Society
1 публикация, 3.57%
|
|
|
Royal Society of Chemistry (RSC)
1 публикация, 3.57%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 публикация, 3.57%
|
|
|
American Chemical Society (ACS)
1 публикация, 3.57%
|
|
|
Kuban State Medical University
1 публикация, 3.57%
|
|
|
Georg Thieme Verlag KG
1 публикация, 3.57%
|
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 публикация, 3.57%
|
|
|
Ovid Technologies (Wolters Kluwer Health)
1 публикация, 3.57%
|
|
|
1
2
3
4
5
6
|
- Мы не учитываем публикации, у которых нет DOI.
- Статистика публикаций обновляется еженедельно.
Вы ученый?
Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.
Метрики
28
Всего цитирований:
28
Цитирований c 2024:
6
(21.43%)
Цитировать
ГОСТ |
RIS |
BibTex
Цитировать
ГОСТ
Скопировать
Vasilenko D. V. et al. Tick-borne flavivirus reproduction inhibitors based on isoxazole core linked with adamantane. // Bioorganic Chemistry. 2019. Vol. 87. pp. 629-637.
ГОСТ со всеми авторами (до 50)
Скопировать
Vasilenko D. V., Dueva E., Kozlovskaya L. I., Zefirov N. A., Grishin Y., Butov G. M., Palyulin V. A., Kuznetsova T. S., Karganova G. G., Zefirova O. N., Osolodkin D. I., Averina E. B. Tick-borne flavivirus reproduction inhibitors based on isoxazole core linked with adamantane. // Bioorganic Chemistry. 2019. Vol. 87. pp. 629-637.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.1016/j.bioorg.2019.03.028
UR - https://doi.org/10.1016/j.bioorg.2019.03.028
TI - Tick-borne flavivirus reproduction inhibitors based on isoxazole core linked with adamantane.
T2 - Bioorganic Chemistry
AU - Vasilenko, Dmitry V.
AU - Dueva, Evgenia
AU - Kozlovskaya, Liubov I.
AU - Zefirov, Nikolay A
AU - Grishin, Yuri
AU - Butov, Gennady M.
AU - Palyulin, V. A.
AU - Kuznetsova, Tamara S.
AU - Karganova, Galina G.
AU - Zefirova, Olga N
AU - Osolodkin, Dmitry I.
AU - Averina, E. B.
PY - 2019
DA - 2019/06/01
PB - Elsevier
SP - 629-637
VL - 87
PMID - 30947098
SN - 0045-2068
SN - 1090-2120
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2019_Vasilenko,
author = {Dmitry V. Vasilenko and Evgenia Dueva and Liubov I. Kozlovskaya and Nikolay A Zefirov and Yuri Grishin and Gennady M. Butov and V. A. Palyulin and Tamara S. Kuznetsova and Galina G. Karganova and Olga N Zefirova and Dmitry I. Osolodkin and E. B. Averina},
title = {Tick-borne flavivirus reproduction inhibitors based on isoxazole core linked with adamantane.},
journal = {Bioorganic Chemistry},
year = {2019},
volume = {87},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/j.bioorg.2019.03.028},
pages = {629--637},
doi = {10.1016/j.bioorg.2019.03.028}
}