Bioorganic Chemistry, volume 103, pages 104229

Recent advances in the development of ligands specifically targeting telomeric multimeric G-quadruplexes

Publication typeJournal Article
Publication date2020-10-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor5.1
ISSN00452068, 10902120
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Abstract
• Telomeric DNA only is able to fold into multimeric G-quadruplexes in the human genome. • Telomeric multimeric G-quadruplexes are biologically more relevant. • Focusing on the structural features and binding modes of the ligands. • Providing new strategies to exploit more sophisticated ligands targeting telomeric multimeric G-quadruplexes. Long human telomeric DNA sequence could form higher-order G-quadruplex structures, namely telomeric multimeric G-quadruplexes. The formation of telomeric multimeric G-quadruplexes has been demonstrated. Several efforts have been devoted to the development of ligands targeting telomeric multimeric G-quadruplexes in recent years. The reported ligands specifically targeting telomeric multimeric G-quadruplexes exhibited either high anticancer activity with effective stabilization ability or distinct fluorescence responses to telomeric multimeric G-quadruplexes. In this review, the ligands including three types of small molecules are discussed which focus on their structural features and binding modes. Furthermore, we put forward the promising prospects and current challenges. This presented review might provide new strategies to exploit more sophisticated ligands targeting telomeric multimeric G-quadruplexes.

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Zhao J., Zhai Q. Recent advances in the development of ligands specifically targeting telomeric multimeric G-quadruplexes // Bioorganic Chemistry. 2020. Vol. 103. p. 104229.
GOST all authors (up to 50) Copy
Zhao J., Zhai Q. Recent advances in the development of ligands specifically targeting telomeric multimeric G-quadruplexes // Bioorganic Chemistry. 2020. Vol. 103. p. 104229.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/j.bioorg.2020.104229
UR - https://doi.org/10.1016/j.bioorg.2020.104229
TI - Recent advances in the development of ligands specifically targeting telomeric multimeric G-quadruplexes
T2 - Bioorganic Chemistry
AU - Zhao, Jingfang
AU - Zhai, Qianqian
PY - 2020
DA - 2020/10/01
PB - Elsevier
SP - 104229
VL - 103
SN - 0045-2068
SN - 1090-2120
ER -
BibTex
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BibTex Copy
@article{2020_Zhao,
author = {Jingfang Zhao and Qianqian Zhai},
title = {Recent advances in the development of ligands specifically targeting telomeric multimeric G-quadruplexes},
journal = {Bioorganic Chemistry},
year = {2020},
volume = {103},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.bioorg.2020.104229},
pages = {104229},
doi = {10.1016/j.bioorg.2020.104229}
}
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