Bioorganic Chemistry, volume 122, pages 105700
Pharmacophore optimization of imidazole chalcones to modulate microtubule dynamics
Publication type: Journal Article
Publication date: 2022-05-01
Journal:
Bioorganic Chemistry
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.1
ISSN: 00452068, 10902120
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Abstract
We recently reported a new class of imidazole-based chalcones as potential antimitotic agents. In view of their promising cytotoxic activity, a comprehensive structure-activity relationship (SAR) of these compounds was undertaken focusing on four major structural variations: the length of the molecule, the Michael acceptor character, the nature and substitution pattern of ring B, and the nature of the amide functionality tethering ring B. These second-generation analogs (IBCs) demonstrated a superior bioactivity profile than the previously reported imidazole chalcones (referred to as IPEs). The analog IBC-2 with one less methylene group (nor series) and para-fluoro substituted ring B demonstrated the best cytotoxicity profile among the library of compounds. A computational analysis of the NCI-60 data associated both IBCs and the previously reported IPEs with the privileged pharmacological pharmacophore of chalcones. Interestingly, biological studies suggest that the imidazole ring is essential for cytotoxic activity of the elongated chalcone analogues. Immunofluorescence studies revealed that IBC-2, unlike IPEs, has the ability to induce microtubule catastrophe independently of Aurora-B inhibition. The effects of IBC-2 on microtubule dynamics are similar to those of Nocodazole, but the cell cycle effects appear to be different. In-silico studies demonstrate that the members of the new series have the ability to bind to the colchicine binding site of β-tubulin with binding scores similar to those of IPEs, corresponding chalcones and Nocodazole. Although tubulin binding can partially explain the biological effects of IBC-2, on-going target identification studies are aimed at further investigation of its biological targets.
Top-30
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International Journal of Molecular Sciences
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Citations by publishers
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 33.33%
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Elsevier
1 publication, 16.67%
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Springer Nature
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
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Karaj E. et al. Pharmacophore optimization of imidazole chalcones to modulate microtubule dynamics // Bioorganic Chemistry. 2022. Vol. 122. p. 105700.
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Karaj E., Dlamini S., Koranne R., Sindi S.H., Perera L., Taylor W.R., Viranga Tillekeratne L.M. Pharmacophore optimization of imidazole chalcones to modulate microtubule dynamics // Bioorganic Chemistry. 2022. Vol. 122. p. 105700.
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TY - JOUR
DO - 10.1016/j.bioorg.2022.105700
UR - https://doi.org/10.1016/j.bioorg.2022.105700
TI - Pharmacophore optimization of imidazole chalcones to modulate microtubule dynamics
T2 - Bioorganic Chemistry
AU - Karaj, E
AU - Dlamini, S
AU - Koranne, R
AU - Sindi, S H
AU - Perera, L
AU - Taylor, W R
AU - Viranga, Tillekeratne
PY - 2022
DA - 2022/05/01 00:00:00
PB - Elsevier
SP - 105700
VL - 122
SN - 0045-2068
SN - 1090-2120
ER -
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@article{2022,
author = {E Karaj and S Dlamini and R Koranne and S H Sindi and L Perera and W R Taylor and Tillekeratne Viranga},
title = {Pharmacophore optimization of imidazole chalcones to modulate microtubule dynamics},
journal = {Bioorganic Chemistry},
year = {2022},
volume = {122},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016/j.bioorg.2022.105700},
pages = {105700},
doi = {10.1016/j.bioorg.2022.105700}
}