Open Access
Acute ampakine treatment ameliorates age-related deficits in long-term potentiation
1
RespireRx Pharmaceuticals Inc.126 Valley Road, Glen Rock, NJ 07452, USA.
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2
Morris Corporate Center III, 400 Interspace Parkway, Parsippany, NJ 07054, USA.
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Publication type: Journal Article
Publication date: 2016-12-01
scimago Q1
wos Q1
SJR: 1.775
CiteScore: 12.8
Impact factor: 7.5
ISSN: 07533322, 19506007
PubMed ID:
27721179
General Medicine
Pharmacology
Abstract
Memory loss observed as a consequence of aging is paralleled by a down-regulation of AMPA-type glutamate receptors (AMPARs) that mediate fast excitatory synaptic transmission. Activation of these receptors enhances long-term potentiation (LTP), a neuronal process demonstrated to be crucial for memory storage and thought to be a cellular substrate of learning and memory. In the present studies, we determined that LTP was reduced in aged rats when compared to young rats and that acute treatment with CX1846, a novel AMPAR positive allosteric modulator, fifteen minutes prior to tetanic stimulation completely reversed the significant deficit in LTP observed in aged rats. These results suggest that CX1846 might be useful for the treatment of age-related memory impairments.
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Total citations:
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Citations from 2025:
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(23.81%)
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GOST
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Radin D. et al. Acute ampakine treatment ameliorates age-related deficits in long-term potentiation // Biomedicine and Pharmacotherapy. 2016. Vol. 84. pp. 806-809.
GOST all authors (up to 50)
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Radin D., Zhong S., Purcell R., Lippa A. Acute ampakine treatment ameliorates age-related deficits in long-term potentiation // Biomedicine and Pharmacotherapy. 2016. Vol. 84. pp. 806-809.
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TY - JOUR
DO - 10.1016/j.biopha.2016.10.016
UR - https://doi.org/10.1016/j.biopha.2016.10.016
TI - Acute ampakine treatment ameliorates age-related deficits in long-term potentiation
T2 - Biomedicine and Pharmacotherapy
AU - Radin, Daniel
AU - Zhong, Sheng
AU - Purcell, Richard
AU - Lippa, Arnold
PY - 2016
DA - 2016/12/01
PB - Elsevier
SP - 806-809
VL - 84
PMID - 27721179
SN - 0753-3322
SN - 1950-6007
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2016_Radin,
author = {Daniel Radin and Sheng Zhong and Richard Purcell and Arnold Lippa},
title = {Acute ampakine treatment ameliorates age-related deficits in long-term potentiation},
journal = {Biomedicine and Pharmacotherapy},
year = {2016},
volume = {84},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.biopha.2016.10.016},
pages = {806--809},
doi = {10.1016/j.biopha.2016.10.016}
}