Biosensors and Bioelectronics, volume 153, pages 112038
Wearable multiplexed biosensor system toward continuous monitoring of metabolites
Publication type: Journal Article
Publication date: 2020-04-01
Journal:
Biosensors and Bioelectronics
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 12.6
ISSN: 09565663, 18734235
General Medicine
Biophysics
Electrochemistry
Biotechnology
Biomedical Engineering
Abstract
Comprehensive metabolic panels are the most reliable and common methods for monitoring general physiology in clinical healthcare. Translation of this clinical practice to personal health and wellness tracking requires reliable, non-invasive, miniaturized, ambulatory, and inexpensive systems for continuous measurement of biochemical analytes. We report the design and characterization of a wearable system with a flexible sensor array for non-invasive and continuous monitoring of human biochemistry. The system includes signal conditioning, processing, and transmission parts for continuous measurement of glucose, lactate, pH, and temperature. The system can operate three discrete electrochemical cells. The system draws 15 mA under continuous operation when powered by a 3.7 V 150 mAh battery. The analog front-end of the electrochemical cells has four potentiostats and three multiplexers for multiplexed and parallel readout from twelve working electrodes. Utilization of redundant working electrodes improves the measurement accuracy of sensors by averaging chronoamperometric responses across the array. The operation of the system is demonstrated in vitro by simultaneous measurement of glucose and lactate, pH, and skin temperature. In benchtop measurements, the sensors are shown to have sensitivities of 26.31 μA mM-1·cm-2 for glucose, 1.49 μA mM-1·cm-2 for lactate, 54 mV·pH-1 for pH, and 0.002 °C-1 for temperature. With the custom wearable system, these values were 0.84 ± 0.03 mV μM-1·cm-2 or glucose, 31.87 ± 9.03 mV mM-1·cm-2 for lactate, 57.18 ± 1.43 mV·pH-1 for pH, and 63.4 μV·°C-1 for temperature. This miniaturized wearable system enables future evaluation of temporal changes of the sweat biomarkers.
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35
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Yokus M. A. et al. Wearable multiplexed biosensor system toward continuous monitoring of metabolites // Biosensors and Bioelectronics. 2020. Vol. 153. p. 112038.
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Yokus M. A., Songkakul T., Pozdin V. A., Bozkurt A., Daniele M. Wearable multiplexed biosensor system toward continuous monitoring of metabolites // Biosensors and Bioelectronics. 2020. Vol. 153. p. 112038.
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TY - JOUR
DO - 10.1016/j.bios.2020.112038
UR - https://doi.org/10.1016/j.bios.2020.112038
TI - Wearable multiplexed biosensor system toward continuous monitoring of metabolites
T2 - Biosensors and Bioelectronics
AU - Yokus, Murat A
AU - Songkakul, Tanner
AU - Pozdin, Vladimir A
AU - Bozkurt, Alper
AU - Daniele, Michael
PY - 2020
DA - 2020/04/01 00:00:00
PB - Elsevier
SP - 112038
VL - 153
SN - 0956-5663
SN - 1873-4235
ER -
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@article{2020_Yokus,
author = {Murat A Yokus and Tanner Songkakul and Vladimir A Pozdin and Alper Bozkurt and Michael Daniele},
title = {Wearable multiplexed biosensor system toward continuous monitoring of metabolites},
journal = {Biosensors and Bioelectronics},
year = {2020},
volume = {153},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016/j.bios.2020.112038},
pages = {112038},
doi = {10.1016/j.bios.2020.112038}
}