Biosensors and Bioelectronics, volume 156, pages 112103
Standalone operation of an EGOFET for ultra-sensitive detection of HIV
Sunil Kumar Sailapu
1
,
Eleonora Macchia
2, 3
,
Irene Merino-Jimenez
1
,
Juan Pablo Esquivel
1
,
Lucia Sarcina
4
,
Gaetano Scamarcio
5
,
Min Li
6
,
L. Torsi
2, 3
,
Neus Sabate
7, 8
2
4
6
Department of Chemistry, University of Utah, Salt Lake City, UT 84112, USA
|
7
Catalan Institution for Research and Advanced Studies (ICREA), P.L. Companys 23, 08010 Barcelona, Spain
|
Publication type: Journal Article
Publication date: 2020-05-01
Journal:
Biosensors and Bioelectronics
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 12.6
ISSN: 09565663, 18734235
General Medicine
Biophysics
Electrochemistry
Biotechnology
Biomedical Engineering
Abstract
A point-of-care (POC) device to enable de-centralized diagnostics can effectively reduce the time to treatment, especially in case of infectious diseases. However, many of the POC solutions presented so far do not comply with the ASSURED (affordable, sensitive, specific, user-friendly, rapid and robust, equipment free, and deliverable to users) guidelines that are needed to ensure their on-field deployment. Herein, we present the proof of concept of a self-powered platform that operates using the analysed fluid, mimicking a blood sample, for early stage detection of HIV-1 infection. The platform contains a smart interfacing circuit to operate an ultra-sensitive electrolyte-gated field-effect transistor (EGOFET) as a sensor and facilitates an easy and affordable readout mechanism. The sensor transduces the bio-recognition event taking place at the gate electrode functionalized with the antibody against the HIV-1 p24 capsid protein, while it is powered via paper-based biofuel cell (BFC) that extracts the energy from the analysed sample itself. The self-powered platform is demonstrated to achieve detection of HIV-1 p24 antigens in fM range, suitable for early diagnosis. From these developments, a cost-effective digital POC device able to detect the transition from “healthy” to “infected” state at single-molecule precision, with no dependency on external power sources while using minimal components and simpler approach, is foreseen.
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1 publication, 1.67%
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1 publication, 1.67%
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1 publication, 1.67%
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1 publication, 1.67%
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1 publication, 1.67%
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1 publication, 1.67%
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1 publication, 1.67%
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1 publication, 1.67%
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Citations by publishers
2
4
6
8
10
12
14
16
18
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Wiley
18 publications, 30%
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Elsevier
10 publications, 16.67%
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American Chemical Society (ACS)
9 publications, 15%
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Springer Nature
5 publications, 8.33%
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Royal Society of Chemistry (RSC)
5 publications, 8.33%
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Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 6.67%
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IEEE
3 publications, 5%
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Public Library of Science (PLoS)
1 publication, 1.67%
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American Association for the Advancement of Science (AAAS)
1 publication, 1.67%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 1.67%
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2
4
6
8
10
12
14
16
18
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Sailapu S. K. et al. Standalone operation of an EGOFET for ultra-sensitive detection of HIV // Biosensors and Bioelectronics. 2020. Vol. 156. p. 112103.
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Sailapu S. K., Macchia E., Merino-Jimenez I., Esquivel J. P., Sarcina L., Scamarcio G., Li M., Torsi L., Sabate N. Standalone operation of an EGOFET for ultra-sensitive detection of HIV // Biosensors and Bioelectronics. 2020. Vol. 156. p. 112103.
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TY - JOUR
DO - 10.1016/j.bios.2020.112103
UR - https://doi.org/10.1016/j.bios.2020.112103
TI - Standalone operation of an EGOFET for ultra-sensitive detection of HIV
T2 - Biosensors and Bioelectronics
AU - Sailapu, Sunil Kumar
AU - Macchia, Eleonora
AU - Merino-Jimenez, Irene
AU - Esquivel, Juan Pablo
AU - Sarcina, Lucia
AU - Scamarcio, Gaetano
AU - Li, Min
AU - Torsi, L.
AU - Sabate, Neus
PY - 2020
DA - 2020/05/01 00:00:00
PB - Elsevier
SP - 112103
VL - 156
SN - 0956-5663
SN - 1873-4235
ER -
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@article{2020_Sailapu,
author = {Sunil Kumar Sailapu and Eleonora Macchia and Irene Merino-Jimenez and Juan Pablo Esquivel and Lucia Sarcina and Gaetano Scamarcio and Min Li and L. Torsi and Neus Sabate},
title = {Standalone operation of an EGOFET for ultra-sensitive detection of HIV},
journal = {Biosensors and Bioelectronics},
year = {2020},
volume = {156},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016/j.bios.2020.112103},
pages = {112103},
doi = {10.1016/j.bios.2020.112103}
}