Biosensors and Bioelectronics, volume 165, pages 112422

Aptamer-integrated nucleic acid circuits for biosensing: Classification, challenges and perspectives

Xiaohong Zhou ¹

Qian Zhu ¹

Yihan Yang ¹

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State Key Joint Laboratory of ESPC, Center for Sensor Technology of Environment and Health, School of Environment, Tsinghua University, Beijing 100084, China |

Publication type: Journal Article

Publication date: 2020-10-01

Elsevier

Journal: Biosensors and Bioelectronics

Quartile SCImago

Quartile WOS

Impact factor: 12.6

ISSN: 09565663, 18734235

DOI: 10.1016/j.bios.2020.112422

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General Medicine

Biophysics

Electrochemistry

Biotechnology

Biomedical Engineering

Abstract

Owing to their high programmability and modularity, autonomous enzyme-free nucleic acid circuits are attracting ever-growing interest as signal amplifiers with potential applications in developing highly sensitive biosensing techniques. Besides nucleic acid input, the biosensing scope of aptamer-integrated nucleic acids could be further expanded to non-nucleic targets by integrating nucleic acid circuits with aptamers-a class of functional oligonucleotides with binding capabilities toward specific targets. By coupling upstream target recognition with downstream signal amplification, aptamer-integrated nucleic acid circuits enable aptasensors with increased sensitivity and enhanced performances, which may act as powerful tools in various fields including environment monitoring, personal care, clinical diagnosis, etc. In designing aptamer-integrated nucleic acid circuits, smart integration between aptamer and nucleic acid circuits plays a crucial role in developing reliable circuits with good performances. To date, although there are plenty of published researches adopting aptamer-integrated nucleic acid circuits as amplifiers in biosensing systems, deep discussion or systematic review on rational design strategies for aptamer-integrated nucleic acid circuits is still lacking. To fill this gap, rational aptamer-nucleic acid circuits integration modes were classified and summarized for the first time based on reviewing the state of art of existing aptamer-integrated nucleic acid circuits. Moreover, theoretical updates in nucleic acid circuits designs and major challenges to be overcome in developing highly sensitive aptamer-integrated nucleic acids based biosensing systems are discussed in this review.

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Biosensors and Bioelectronics	Biosensors and Bioelectronics, 6, 13.04% Biosensors and Bioelectronics 6 publications, 13.04%
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Coordination Chemistry Reviews	Coordination Chemistry Reviews, 2, 4.35% Coordination Chemistry Reviews 2 publications, 4.35%
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Journal of Radioanalytical and Nuclear Chemistry	Journal of Radioanalytical and Nuclear Chemistry, 1, 2.17% Journal of Radioanalytical and Nuclear Chemistry 1 publication, 2.17%
Frontiers in Chemistry	Frontiers in Chemistry, 1, 2.17% Frontiers in Chemistry 1 publication, 2.17%
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Biotechnology and Bioengineering	Biotechnology and Bioengineering, 1, 2.17% Biotechnology and Bioengineering 1 publication, 2.17%
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The Analyst	The Analyst, 1, 2.17% The Analyst 1 publication, 2.17%
New Journal of Chemistry	New Journal of Chemistry, 1, 2.17% New Journal of Chemistry 1 publication, 2.17%
Advanced Materials	Advanced Materials, 1, 2.17% Advanced Materials 1 publication, 2.17%
Chemistry and Biodiversity	Chemistry and Biodiversity, 1, 2.17% Chemistry and Biodiversity 1 publication, 2.17%
ChemPlusChem	ChemPlusChem, 1, 2.17% ChemPlusChem 1 publication, 2.17%
Biomedical Analysis	Biomedical Analysis, 1, 2.17% Biomedical Analysis 1 publication, 2.17%
Analytical Chemistry	Analytical Chemistry, 1, 2.17% Analytical Chemistry 1 publication, 2.17%
Trends in Food Science and Technology	Trends in Food Science and Technology, 1, 2.17% Trends in Food Science and Technology 1 publication, 2.17%
Russian Chemical Reviews	Russian Chemical Reviews, 1, 2.17% Russian Chemical Reviews 1 publication, 2.17%
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Citations by publishers

	5 10 15 20 25
Elsevier	Elsevier, 25, 54.35% Elsevier 25 publications, 54.35%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 6, 13.04% Royal Society of Chemistry (RSC) 6 publications, 13.04%
Wiley	Wiley, 5, 10.87% Wiley 5 publications, 10.87%
American Chemical Society (ACS)	American Chemical Society (ACS), 5, 10.87% American Chemical Society (ACS) 5 publications, 10.87%
Springer Nature	Springer Nature, 2, 4.35% Springer Nature 2 publications, 4.35%
Frontiers Media S.A.	Frontiers Media S.A., 1, 2.17% Frontiers Media S.A. 1 publication, 2.17%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 1, 2.17% Multidisciplinary Digital Publishing Institute (MDPI) 1 publication, 2.17%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 2.17% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 2.17%
	5 10 15 20 25

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Zhou X., Zhu Q., Yang Y. Aptamer-integrated nucleic acid circuits for biosensing: Classification, challenges and perspectives // Biosensors and Bioelectronics. 2020. Vol. 165. p. 112422.

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Zhou X., Zhu Q., Yang Y. Aptamer-integrated nucleic acid circuits for biosensing: Classification, challenges and perspectives // Biosensors and Bioelectronics. 2020. Vol. 165. p. 112422.

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TY - JOUR

DO - 10.1016/j.bios.2020.112422

UR - https://doi.org/10.1016/j.bios.2020.112422

TI - Aptamer-integrated nucleic acid circuits for biosensing: Classification, challenges and perspectives

T2 - Biosensors and Bioelectronics

AU - Zhou, Xiaohong

AU - Zhu, Qian

AU - Yang, Yihan

PY - 2020

DA - 2020/10/01 00:00:00

PB - Elsevier

SP - 112422

VL - 165

SN - 0956-5663

SN - 1873-4235

ER -

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@article{2020_Zhou,

author = {Xiaohong Zhou and Qian Zhu and Yihan Yang},

title = {Aptamer-integrated nucleic acid circuits for biosensing: Classification, challenges and perspectives},

journal = {Biosensors and Bioelectronics},

year = {2020},

volume = {165},

publisher = {Elsevier},

month = {oct},

url = {https://doi.org/10.1016/j.bios.2020.112422},

pages = {112422},

doi = {10.1016/j.bios.2020.112422}

}

Found error?

Publisher

Elsevier

Journal

Biosensors and Bioelectronics

Quartile SCImago

Quartile WOS

Impact factor

12.6

ISSN

09565663 (Print)
18734235 (Electronic)