Biosensors and Bioelectronics, volume 210, pages 114235
Ultra-sensitive dielectrophoretic surface charge multiplex detection inside a micro-dielectrophoretic device
Kang In Yeo
1
,
Insu Park
2
,
Sang Hyun Lee
1
,
Sei Young Lee
1
,
Woojin Chang
3
,
Rashid Bashir
2
,
Seungyeop Choi
1
,
Sangwoo Lee
1
Publication type: Journal Article
Publication date: 2022-08-01
Journal:
Biosensors and Bioelectronics
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 12.6
ISSN: 09565663, 18734235
General Medicine
Biophysics
Electrochemistry
Biotechnology
Biomedical Engineering
Abstract
Label-free dielectrophoretic force-based surface charge detection has shown great potential for highly sensitive and selective sensing of metal ions and small biomolecules. However, this method suffers from a complex calibration process and measurement signal interference in simultaneous multi-analyte detection, thus creating difficulties in multiplex detection. We have developed a method to overcome these issues based on the optical discrimination of the dielectrophoretic behaviors of multiple microparticle probes considering the surface charge difference before and after self-assembling conjugation. In this report, we demonstrate and characterize this dielectrophoretic force-based surface charge detection method with particle probes functionalized by various biomolecules. This technique achieved an attomolar limit of detection (LOD) for Hg2+ in distilled water and a femtomolar LOD in drinking water using DNA aptamer-functionalized particle probes. More importantly, using two different DNA aptamer-functionalized particle probes for Hg2+ and Ag+, label-free dielectrophoretic multiplex detection of these species in drinking water with a femtomolar and a nanomolar LOD was achieved for the first time.
Top-30
Citations by journals
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1
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Journal of Hazardous Materials
1 publication, 50%
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Russian Chemical Reviews
1 publication, 50%
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1
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Citations by publishers
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1
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Elsevier
1 publication, 50%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 50%
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1
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- Statistics recalculated weekly.
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Yeo K. I. et al. Ultra-sensitive dielectrophoretic surface charge multiplex detection inside a micro-dielectrophoretic device // Biosensors and Bioelectronics. 2022. Vol. 210. p. 114235.
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Yeo K. I., Park I., Lee S. H., Lee S. Y., Chang W., Bashir R., Choi S., Lee S. Ultra-sensitive dielectrophoretic surface charge multiplex detection inside a micro-dielectrophoretic device // Biosensors and Bioelectronics. 2022. Vol. 210. p. 114235.
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TY - JOUR
DO - 10.1016/j.bios.2022.114235
UR - https://doi.org/10.1016/j.bios.2022.114235
TI - Ultra-sensitive dielectrophoretic surface charge multiplex detection inside a micro-dielectrophoretic device
T2 - Biosensors and Bioelectronics
AU - Yeo, Kang In
AU - Park, Insu
AU - Lee, Sang Hyun
AU - Lee, Sei Young
AU - Chang, Woojin
AU - Bashir, Rashid
AU - Choi, Seungyeop
AU - Lee, Sangwoo
PY - 2022
DA - 2022/08/01 00:00:00
PB - Elsevier
SP - 114235
VL - 210
SN - 0956-5663
SN - 1873-4235
ER -
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@article{2022_Yeo,
author = {Kang In Yeo and Insu Park and Sang Hyun Lee and Sei Young Lee and Woojin Chang and Rashid Bashir and Seungyeop Choi and Sangwoo Lee},
title = {Ultra-sensitive dielectrophoretic surface charge multiplex detection inside a micro-dielectrophoretic device},
journal = {Biosensors and Bioelectronics},
year = {2022},
volume = {210},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.bios.2022.114235},
pages = {114235},
doi = {10.1016/j.bios.2022.114235}
}
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