Synthesis and structure–activity relationship of 7-(substituted)-aminomethyl-4-quinolone-3-carboxylic acid derivatives
2
Center for Drug Development, Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshanbeiyi Road, Shanghai 200437, PR China
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Publication type: Journal Article
Publication date: 2007-12-01
scimago Q2
wos Q1
SJR: 0.608
CiteScore: 6.7
Impact factor: 3.0
ISSN: 09680896, 14643391
PubMed ID:
17826097
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
Gram-positive organisms have re-emerged as the major hospital pathogens, which make the unmet medical needs for antibacterial therapy even worse. In searching for potent agents against Gram-positive pathogens, novel 7-(substituted)-aminomethyl-quinolone-3-carboxylic acids were designed, synthesized, and evaluated for their antibacterial activities in vitro. Many 7-monoarylaminomethyl derivatives exhibited high potency against Gram-positive organisms compared to reference agents: vancomycin and pazufloxacin. Additionally, a few 7-monoalkylaminomethyl derivatives exhibited good activities against both Gram-positive and Gram-negative organisms.
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GOST
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Zhang Z., Yu A., Zhou W. Synthesis and structure–activity relationship of 7-(substituted)-aminomethyl-4-quinolone-3-carboxylic acid derivatives // Bioorganic and Medicinal Chemistry. 2007. Vol. 15. No. 23. pp. 7274-7280.
GOST all authors (up to 50)
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Zhang Z., Yu A., Zhou W. Synthesis and structure–activity relationship of 7-(substituted)-aminomethyl-4-quinolone-3-carboxylic acid derivatives // Bioorganic and Medicinal Chemistry. 2007. Vol. 15. No. 23. pp. 7274-7280.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.bmc.2007.08.031
UR - https://doi.org/10.1016/j.bmc.2007.08.031
TI - Synthesis and structure–activity relationship of 7-(substituted)-aminomethyl-4-quinolone-3-carboxylic acid derivatives
T2 - Bioorganic and Medicinal Chemistry
AU - Zhang, Zhenfa
AU - Yu, Aizhen
AU - Zhou, Weicheng
PY - 2007
DA - 2007/12/01
PB - Elsevier
SP - 7274-7280
IS - 23
VL - 15
PMID - 17826097
SN - 0968-0896
SN - 1464-3391
ER -
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BibTex (up to 50 authors)
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@article{2007_Zhang,
author = {Zhenfa Zhang and Aizhen Yu and Weicheng Zhou},
title = {Synthesis and structure–activity relationship of 7-(substituted)-aminomethyl-4-quinolone-3-carboxylic acid derivatives},
journal = {Bioorganic and Medicinal Chemistry},
year = {2007},
volume = {15},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.bmc.2007.08.031},
number = {23},
pages = {7274--7280},
doi = {10.1016/j.bmc.2007.08.031}
}
Cite this
MLA
Copy
Zhang, Zhenfa, et al. “Synthesis and structure–activity relationship of 7-(substituted)-aminomethyl-4-quinolone-3-carboxylic acid derivatives.” Bioorganic and Medicinal Chemistry, vol. 15, no. 23, Dec. 2007, pp. 7274-7280. https://doi.org/10.1016/j.bmc.2007.08.031.