Bioorganic and Medicinal Chemistry

, том 20 , издание 4 , страницы 1545-1556

Quinoline- and isoquinoline-sulfonamide derivatives of LCAP as potent CNS multi-receptor—5-HT1A/5-HT2A/5-HT7 and D2/D3/D4—agents: The synthesis and pharmacological evaluation

Тип публикации: Journal Article

Дата публикации: 2012-02-01

Elsevier

Bioorganic and Medicinal Chemistry

scimago Q2

wos Q1

БС1

SJR: 0.608

CiteScore: 6.7

Impact factor: 3

ISSN: 09680896, 14643391

DOI: 10.1016/j.bmc.2011.12.039

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PubMed ID: 22277589

Organic Chemistry

Drug Discovery

Biochemistry

Molecular Biology

Pharmaceutical Science

Clinical Biochemistry

Molecular Medicine

Краткое описание

Two series of arylpiperazinyl-alkyl quinoline-, isoquinoline-, naphthalene-sulfonamides with flexible (13-26) and semi-rigid (33-36) alkylene spacer were synthesized and evaluated for 5-HT(1A), 5-HT(2A), 5-HT(6), 5-HT(7) and selected compounds for D(2), D(3), D(4) receptors. The compounds with a mixed 5-HT and D receptors profile 16 (N-{4-[4-(3-chlorophenyl)-piperazin-1-yl]-butyl}-3-quinolinesulfonamide) and 36 (4-(4-{2-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethyl}-piperidine-1-sulfonyl)-isoquinoline), displaying antagonistic activity at 5-HT(7), 5-HT(2A), D(2) postsynaptic sites, produced antidepressant-like effects in the forced swim test in mice and showed significant anxiolytic activity in the plus-maze test in rats. The lead compound 36, a multi-receptor 5-HT(2A)/5-HT(7)/D(2)/D(3)/D(4) agent, also displayed significant antipsychotic properties in the MK-801-induced hyperlocomotor activity in mice.

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European Journal of Medicinal Chemistry	European Journal of Medicinal Chemistry, 14, 22.58% European Journal of Medicinal Chemistry 14 публикаций, 22.58%
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Zajdel P. et al. Quinoline- and isoquinoline-sulfonamide derivatives of LCAP as potent CNS multi-receptor—5-HT1A/5-HT2A/5-HT7 and D2/D3/D4—agents: The synthesis and pharmacological evaluation // Bioorganic and Medicinal Chemistry. 2012. Vol. 20. No. 4. pp. 1545-1556.

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Zajdel P., Marciniec K., Maślankiewicz [] A., Satała G., Duszyńska B., Bojarski A. J., Partyka A., Jastrzębska-Więsek M., Wróbel D., Wesołowska A., Pawłowski M. Quinoline- and isoquinoline-sulfonamide derivatives of LCAP as potent CNS multi-receptor—5-HT1A/5-HT2A/5-HT7 and D2/D3/D4—agents: The synthesis and pharmacological evaluation // Bioorganic and Medicinal Chemistry. 2012. Vol. 20. No. 4. pp. 1545-1556.

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TY - JOUR

DO - 10.1016/j.bmc.2011.12.039

UR - https://doi.org/10.1016/j.bmc.2011.12.039

TI - Quinoline- and isoquinoline-sulfonamide derivatives of LCAP as potent CNS multi-receptor—5-HT1A/5-HT2A/5-HT7 and D2/D3/D4—agents: The synthesis and pharmacological evaluation

T2 - Bioorganic and Medicinal Chemistry

AU - Zajdel, P.

AU - Marciniec, Krzysztof

AU - Maślankiewicz [], Andrzej

AU - Satała, Grzegorz

AU - Duszyńska, Beata

AU - Bojarski, Andrzej J

AU - Partyka, Anna

AU - Jastrzębska-Więsek, Magdalena

AU - Wróbel, Dagmara

AU - Wesołowska, Anna

AU - Pawłowski, M.

PY - 2012

DA - 2012/02/01

PB - Elsevier

SP - 1545-1556

IS - 4

VL - 20

PMID - 22277589

SN - 0968-0896

SN - 1464-3391

ER -

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@article{2012_Zajdel,

author = {P. Zajdel and Krzysztof Marciniec and Andrzej Maślankiewicz [] and Grzegorz Satała and Beata Duszyńska and Andrzej J Bojarski and Anna Partyka and Magdalena Jastrzębska-Więsek and Dagmara Wróbel and Anna Wesołowska and M. Pawłowski},

title = {Quinoline- and isoquinoline-sulfonamide derivatives of LCAP as potent CNS multi-receptor—5-HT1A/5-HT2A/5-HT7 and D2/D3/D4—agents: The synthesis and pharmacological evaluation},

journal = {Bioorganic and Medicinal Chemistry},

year = {2012},

volume = {20},

publisher = {Elsevier},

month = {feb},

url = {https://doi.org/10.1016/j.bmc.2011.12.039},

number = {4},

pages = {1545--1556},

doi = {10.1016/j.bmc.2011.12.039}

}

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Zajdel, P., et al. “Quinoline- and isoquinoline-sulfonamide derivatives of LCAP as potent CNS multi-receptor—5-HT1A/5-HT2A/5-HT7 and D2/D3/D4—agents: The synthesis and pharmacological evaluation.” Bioorganic and Medicinal Chemistry, vol. 20, no. 4, Feb. 2012, pp. 1545-1556. https://doi.org/10.1016/j.bmc.2011.12.039.

Издатель

Elsevier

Журнал

Bioorganic and Medicinal Chemistry

scimago Q2

wos Q1

БС1

SJR

0.608

CiteScore

6.7

Impact factor

ISSN

09680896 (Print)

14643391 (Electronic)