Bioorganic and Medicinal Chemistry

, том 21 , издание 14 , страницы 4151-4157

Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof

Mikhail S. Novikov ¹

Maria P Paramonova ¹

Anastasia Khandazhinskaya ²

G. Andrei ^{3, 4, 5}

Robert Snoeck ^{3, 4, 5}

Denis A Babkov ¹

A.A. Ozerov ¹

A. O. Chizhov ⁶

Jan Balzarini ^{3, 4, 5}

Katherine L. Seley-Radtke ⁷

Скрыть аффилиации авторов Показать аффилиации авторов: 7 аффилиаций

Department of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd 400131, Russia |

Engelhardt Institute of Molecular Biology, Russian Academy of Science, Vavilov Str. 32, Moscow 119991, Russia |

Rega Institute for Medical Research

⁴

KU Leuven Minderbroedersstraat 10 |

⁵

Leuven B-3000 Belgium |

⁶

Zelinsky Institute of Organic Chemistry, Russian Academy of Science, Leninsky pr., 47, Moscow 119991, Russia. |

⁷

Department of Chemistry and Biochemistry, University of Maryland Baltimore County 1000 Hilltop Circle, Baltimore MD 21250, USA |

Тип публикации: Journal Article

Дата публикации: 2013-07-01

Elsevier

Bioorganic and Medicinal Chemistry

scimago Q2

wos Q1

БС1

SJR: 0.608

CiteScore: 6.7

Impact factor: 3.0

ISSN: 09680896, 14643391

DOI: 10.1016/j.bmc.2013.05.009

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PubMed ID: 23743443

Organic Chemistry

Drug Discovery

Biochemistry

Molecular Biology

Pharmaceutical Science

Clinical Biochemistry

Molecular Medicine

Краткое описание

HCMV infection represents a life-threatening condition for immunocompromised patients and newborn infants and novel anti-HCMV agents are clearly needed. In this regard, a series of 1-[ω-(phenoxy)alkyl]uracil derivatives were synthesized and examined for antiviral properties. Compounds 17, 20, 24 and 28 were found to exhibit highly specific and promising inhibitory activity against HCMV replication in HEL cell cultures with EC50 values within 5.5-12μM range. Further studies should be undertaken to elucidate the mechanism of action of these compounds and the structure-activity relationship for the linker region.

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Санкт-Петербургский государственный университет

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Институт молекулярной биологии им. В.А. Энгельгардта РАН

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Волгоградский государственный медицинский университет

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Babkov D. A. et al. Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof // Bioorganic and Medicinal Chemistry. 2013. Vol. 21. No. 14. pp. 4151-4157.

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Novikov M. S., Paramonova M. P., Khandazhinskaya A., Andrei G., Snoeck R., Babkov D. A., Ozerov A., Chizhov A. O., Balzarini J., Seley-Radtke K. L. Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof // Bioorganic and Medicinal Chemistry. 2013. Vol. 21. No. 14. pp. 4151-4157.

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TY - JOUR

DO - 10.1016/j.bmc.2013.05.009

UR - https://doi.org/10.1016/j.bmc.2013.05.009

TI - Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof

T2 - Bioorganic and Medicinal Chemistry

AU - Novikov, Mikhail S.

AU - Paramonova, Maria P

AU - Khandazhinskaya, Anastasia

AU - Andrei, G.

AU - Snoeck, Robert

AU - Babkov, Denis A

AU - Ozerov, A.A.

AU - Chizhov, A. O.

AU - Balzarini, Jan

AU - Seley-Radtke, Katherine L.

PY - 2013

DA - 2013/07/01

PB - Elsevier

SP - 4151-4157

IS - 14

VL - 21

PMID - 23743443

SN - 0968-0896

SN - 1464-3391

ER -

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@article{2013_Babkov,

author = {Mikhail S. Novikov and Maria P Paramonova and Anastasia Khandazhinskaya and G. Andrei and Robert Snoeck and Denis A Babkov and A.A. Ozerov and A. O. Chizhov and Jan Balzarini and Katherine L. Seley-Radtke},

title = {Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof},

journal = {Bioorganic and Medicinal Chemistry},

year = {2013},

volume = {21},

publisher = {Elsevier},

month = {jul},

url = {https://doi.org/10.1016/j.bmc.2013.05.009},

number = {14},

pages = {4151--4157},

doi = {10.1016/j.bmc.2013.05.009}

}

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Babkov, Denis A., et al. “Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof.” Bioorganic and Medicinal Chemistry, vol. 21, no. 14, Jul. 2013, pp. 4151-4157. https://doi.org/10.1016/j.bmc.2013.05.009.