Toward the discovery of dual HCMV–VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides
Denis A Babkov
1
,
A. O. Chizhov
3
,
G. Andrei
4, 5, 6
,
Robert Snoeck
4, 5, 6
,
Mikhail S. Novikov
1
4
Rega Institute for Medical Research
Publication type: Journal Article
Publication date: 2015-11-01
scimago Q2
wos Q1
SJR: 0.608
CiteScore: 6.7
Impact factor: 3.0
ISSN: 09680896, 14643391
PubMed ID:
26443550
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
The need for novel therapeutic options to fight herpesvirus infections still persists. Herein we report the design, synthesis and antiviral evaluation of a new family of non-nucleoside antivirals, derived from 1-[ω-(4-bromophenoxy)alkyl]uracil derivatives – previously reported inhibitors of human cytomegalovirus (HCMV). Introduction of the N -(4-phenoxyphenyl)acetamide side chain at N 3 increased their potency and widened activity spectrum. The most active compounds in the series exhibit submicromolar activity against different viral strains of HCMV and varicella zoster virus (VZV) replication in HEL cell cultures. Inactivity against other DNA and RNA viruses, including herpes simplex virus 1/2, points to a novel mechanism of antiviral action.
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13
Total citations:
13
Citations from 2025:
1
(7.69%)
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Babkov D. A. et al. Toward the discovery of dual HCMV–VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides // Bioorganic and Medicinal Chemistry. 2015. Vol. 23. No. 21. pp. 7035-7044.
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Babkov D. A., Khandazhinskaya A., Chizhov A. O., Andrei G., Snoeck R., Seley-Radtke K. L., Novikov M. S. Toward the discovery of dual HCMV–VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides // Bioorganic and Medicinal Chemistry. 2015. Vol. 23. No. 21. pp. 7035-7044.
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TY - JOUR
DO - 10.1016/j.bmc.2015.09.033
UR - https://doi.org/10.1016/j.bmc.2015.09.033
TI - Toward the discovery of dual HCMV–VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides
T2 - Bioorganic and Medicinal Chemistry
AU - Babkov, Denis A
AU - Khandazhinskaya, Anastasia
AU - Chizhov, A. O.
AU - Andrei, G.
AU - Snoeck, Robert
AU - Seley-Radtke, Katherine L.
AU - Novikov, Mikhail S.
PY - 2015
DA - 2015/11/01
PB - Elsevier
SP - 7035-7044
IS - 21
VL - 23
PMID - 26443550
SN - 0968-0896
SN - 1464-3391
ER -
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BibTex (up to 50 authors)
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@article{2015_Babkov,
author = {Denis A Babkov and Anastasia Khandazhinskaya and A. O. Chizhov and G. Andrei and Robert Snoeck and Katherine L. Seley-Radtke and Mikhail S. Novikov},
title = {Toward the discovery of dual HCMV–VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides},
journal = {Bioorganic and Medicinal Chemistry},
year = {2015},
volume = {23},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/j.bmc.2015.09.033},
number = {21},
pages = {7035--7044},
doi = {10.1016/j.bmc.2015.09.033}
}
Cite this
MLA
Copy
Babkov, Denis A., et al. “Toward the discovery of dual HCMV–VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides.” Bioorganic and Medicinal Chemistry, vol. 23, no. 21, Nov. 2015, pp. 7035-7044. https://doi.org/10.1016/j.bmc.2015.09.033.
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