The recent progress of isoxazole in medicinal chemistry
Publication type: Journal Article
Publication date: 2018-07-01
scimago Q2
wos Q1
SJR: 0.608
CiteScore: 6.7
Impact factor: 3.0
ISSN: 09680896, 14643391
PubMed ID:
29853341
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
Isoxazole compounds exhibit a wide spectrum of targets and broad biological activities. Developing compounds with heterocycle rings has been one of the trends. The integration of isoxazole ring can offer improved physical-chemical properties. Because of the unique profiles, isoxazole ring becomes a popular moiety in compounds design. In this review article, the major focus has been paid to the applications of isoxazole compounds in treating multiple diseases, including anticancer, antimicrobial, anti-inflammatory, etc. Strategies for compounds design for preclinical, clinical, and FDA approved drugs were discussed. Also, the emphasis has been addressed to the future perspectives and trend for the application.
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346
Total citations:
346
Citations from 2025:
73
(21.1%)
Cite this
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GOST
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Zhu J. et al. The recent progress of isoxazole in medicinal chemistry // Bioorganic and Medicinal Chemistry. 2018. Vol. 26. No. 12. pp. 3065-3075.
GOST all authors (up to 50)
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Zhu J., Mo J., Lin H. Z., Chen Y., Sun H. The recent progress of isoxazole in medicinal chemistry // Bioorganic and Medicinal Chemistry. 2018. Vol. 26. No. 12. pp. 3065-3075.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.bmc.2018.05.013
UR - https://doi.org/10.1016/j.bmc.2018.05.013
TI - The recent progress of isoxazole in medicinal chemistry
T2 - Bioorganic and Medicinal Chemistry
AU - Zhu, Jie
AU - Mo, Jun
AU - Lin, Hong Zhi
AU - Chen, Yao
AU - Sun, Haopeng
PY - 2018
DA - 2018/07/01
PB - Elsevier
SP - 3065-3075
IS - 12
VL - 26
PMID - 29853341
SN - 0968-0896
SN - 1464-3391
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Zhu,
author = {Jie Zhu and Jun Mo and Hong Zhi Lin and Yao Chen and Haopeng Sun},
title = {The recent progress of isoxazole in medicinal chemistry},
journal = {Bioorganic and Medicinal Chemistry},
year = {2018},
volume = {26},
publisher = {Elsevier},
month = {jul},
url = {https://doi.org/10.1016/j.bmc.2018.05.013},
number = {12},
pages = {3065--3075},
doi = {10.1016/j.bmc.2018.05.013}
}
Cite this
MLA
Copy
Zhu, Jie, et al. “The recent progress of isoxazole in medicinal chemistry.” Bioorganic and Medicinal Chemistry, vol. 26, no. 12, Jul. 2018, pp. 3065-3075. https://doi.org/10.1016/j.bmc.2018.05.013.