Chemical reactivity and uses of 1-phenyl-3-methyl-5-pyrazolone (PMP), also known as edaravone
Christian Bailly
1
,
Paul Emile Hecquet
2
,
Mostafa Kouach
2
,
Xavier Thuru
3
,
Jean-François Goossens
2
1
OncoWitan, Lille (Wasquehal), 59290, France
|
Publication type: Journal Article
Publication date: 2020-05-01
scimago Q2
wos Q1
SJR: 0.608
CiteScore: 6.7
Impact factor: 3.0
ISSN: 09680896, 14643391
PubMed ID:
32241621
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
1-Phenyl-3-methyl-5-pyrazolone is a reagent, known as PMP, used to derivatize monosaccharides for the study of polysaccharides composition and structure, and for the dosage of carbohydrates in complex media. The same molecule is also known as edaravone, a drug approved for the treatment of stroke and amyotrophic lateral sclerosis. It is also a reactive molecule susceptible to form stable adducts with aromatic aldehydes, such as formylpterin and vanillin. In addition, the molecule serves as a scaffold to design of edaravone analogs and drug conjugates, with various pharmacological properties (antioxidant, anticancer, antiviral). We have analyzed the multiple usages of PMP/edaravone to highlight the reactivity of the molecule and its wide range of applications. This phenyl-pyrazolone compound, considered by many as a biochemical reagent and by other as a clinically useful drug, has not yet revealed the full extent of its capacities and benefits.
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Bailly C. et al. Chemical reactivity and uses of 1-phenyl-3-methyl-5-pyrazolone (PMP), also known as edaravone // Bioorganic and Medicinal Chemistry. 2020. Vol. 28. No. 10. p. 115463.
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Bailly C., Hecquet P. E., Kouach M., Thuru X., Goossens J. Chemical reactivity and uses of 1-phenyl-3-methyl-5-pyrazolone (PMP), also known as edaravone // Bioorganic and Medicinal Chemistry. 2020. Vol. 28. No. 10. p. 115463.
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TY - JOUR
DO - 10.1016/j.bmc.2020.115463
UR - https://doi.org/10.1016/j.bmc.2020.115463
TI - Chemical reactivity and uses of 1-phenyl-3-methyl-5-pyrazolone (PMP), also known as edaravone
T2 - Bioorganic and Medicinal Chemistry
AU - Bailly, Christian
AU - Hecquet, Paul Emile
AU - Kouach, Mostafa
AU - Thuru, Xavier
AU - Goossens, Jean-François
PY - 2020
DA - 2020/05/01
PB - Elsevier
SP - 115463
IS - 10
VL - 28
PMID - 32241621
SN - 0968-0896
SN - 1464-3391
ER -
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@article{2020_Bailly,
author = {Christian Bailly and Paul Emile Hecquet and Mostafa Kouach and Xavier Thuru and Jean-François Goossens},
title = {Chemical reactivity and uses of 1-phenyl-3-methyl-5-pyrazolone (PMP), also known as edaravone},
journal = {Bioorganic and Medicinal Chemistry},
year = {2020},
volume = {28},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016/j.bmc.2020.115463},
number = {10},
pages = {115463},
doi = {10.1016/j.bmc.2020.115463}
}
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MLA
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Bailly, Christian, et al. “Chemical reactivity and uses of 1-phenyl-3-methyl-5-pyrazolone (PMP), also known as edaravone.” Bioorganic and Medicinal Chemistry, vol. 28, no. 10, May. 2020, p. 115463. https://doi.org/10.1016/j.bmc.2020.115463.