Bioorganic and Medicinal Chemistry

, volume 29 , pages 115897

Evaluation of imidazo[2,1–b]thiazole-based anticancer agents in one decade (2011–2020): Current status and future prospects

Rawan M Sbenati ¹

M Semreen ^{2, 3}

Ahlam M Semreen ⁴

Mahmoud M. Shehata ⁴

Fai M Alsaghir ⁴

Hide authors affiliations Show authors affiliations: 4 affiliations

Sharjah Institute for Medical Research, University of Sharjah, Sharjah, 27272 , United Arab Emirates |

Sharjah Institute for Medical Research, University of Sharjah, Sharjah, 27272, United Arab Emirates |

Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah, 27272, United Arab Emirates. |

⁴

Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah-27272, United Arab Emirates. |

Publication type: Journal Article

Publication date: 2021-01-01

Elsevier

Bioorganic and Medicinal Chemistry

scimago Q2

wos Q1

SJR: 0.608

CiteScore: 6.7

Impact factor: 3.0

ISSN: 09680896, 14643391

DOI: 10.1016/j.bmc.2020.115897

Copy DOI

PubMed ID: 33316752

Organic Chemistry

Drug Discovery

Biochemistry

Molecular Biology

Pharmaceutical Science

Clinical Biochemistry

Molecular Medicine

Abstract

Several reports have highlighted imidazo[2,1-b]thiazole derivatives as potential antiproliferative agents. They act through kinase inhibition, tubulin inhibition, and other molecular mechanisms of action. In the current article, we reviewed the imidazo[2,1-b]thiazole-based compounds that were reported as anticancer agents. Their biological characteristics as well as structure-activity relationship (SAR) have been reviewed and evaluated. Our main focus was on the reports published in the literature from 2011 to 2020.

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GOST Copy

Sbenati R. M. et al. Evaluation of imidazo[2,1–b]thiazole-based anticancer agents in one decade (2011–2020): Current status and future prospects // Bioorganic and Medicinal Chemistry. 2021. Vol. 29. p. 115897.

GOST all authors (up to 50) Copy

Sbenati R. M., Semreen M., Semreen A. M., Shehata M. M., Alsaghir F. M. Evaluation of imidazo[2,1–b]thiazole-based anticancer agents in one decade (2011–2020): Current status and future prospects // Bioorganic and Medicinal Chemistry. 2021. Vol. 29. p. 115897.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.bmc.2020.115897

UR - https://doi.org/10.1016/j.bmc.2020.115897

TI - Evaluation of imidazo[2,1–b]thiazole-based anticancer agents in one decade (2011–2020): Current status and future prospects

T2 - Bioorganic and Medicinal Chemistry

AU - Sbenati, Rawan M

AU - Semreen, M

AU - Semreen, Ahlam M

AU - Shehata, Mahmoud M.

AU - Alsaghir, Fai M

PY - 2021

DA - 2021/01/01

PB - Elsevier

SP - 115897

VL - 29

PMID - 33316752

SN - 0968-0896

SN - 1464-3391

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2021_Sbenati,

author = {Rawan M Sbenati and M Semreen and Ahlam M Semreen and Mahmoud M. Shehata and Fai M Alsaghir},

title = {Evaluation of imidazo[2,1–b]thiazole-based anticancer agents in one decade (2011–2020): Current status and future prospects},

journal = {Bioorganic and Medicinal Chemistry},

year = {2021},

volume = {29},

publisher = {Elsevier},

month = {jan},

url = {https://doi.org/10.1016/j.bmc.2020.115897},

pages = {115897},

doi = {10.1016/j.bmc.2020.115897}

}

Publisher

Elsevier

Journal

Bioorganic and Medicinal Chemistry

scimago Q2

wos Q1

SJR

0.608

CiteScore

6.7

Impact factor

3.0

ISSN

09680896 (Print)

14643391 (Electronic)