Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists.
Publication type: Journal Article
Publication date: 2005-09-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
15982881
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
8-Aryl-1,3a,8-triaza-cyclopenta[a]indenes represent a novel series of high binding affinity corticotropin-releasing factor 1 receptor antagonists. Here, we report their synthesis, SAR, and pharmacokinetic properties of compound 8e (K(i) = 23 nM).
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Metrics
38
Total citations:
38
Citations from 2025:
1
(2.63%)
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MLA
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GOST
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Han X. et al. Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists. // Bioorganic and Medicinal Chemistry Letters. 2005. Vol. 15. No. 18. pp. 4029-4032.
GOST all authors (up to 50)
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Han X., Pin S. S., Burris K., Fung L. K., Huang S., Taber M. T., Zhang J., Dubowchik G. M. Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists. // Bioorganic and Medicinal Chemistry Letters. 2005. Vol. 15. No. 18. pp. 4029-4032.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.bmcl.2005.06.028
UR - https://doi.org/10.1016/j.bmcl.2005.06.028
TI - Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists.
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Han, Xiaojun
AU - Pin, Sokhom S.
AU - Burris, Kevin
AU - Fung, Lawrence K.
AU - Huang, Stella
AU - Taber, Matthew T.
AU - Zhang, Jie
AU - Dubowchik, Gene M.
PY - 2005
DA - 2005/09/01
PB - Elsevier
SP - 4029-4032
IS - 18
VL - 15
PMID - 15982881
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2005_Han,
author = {Xiaojun Han and Sokhom S. Pin and Kevin Burris and Lawrence K. Fung and Stella Huang and Matthew T. Taber and Jie Zhang and Gene M. Dubowchik},
title = {Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists.},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2005},
volume = {15},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/j.bmcl.2005.06.028},
number = {18},
pages = {4029--4032},
doi = {10.1016/j.bmcl.2005.06.028}
}
Cite this
MLA
Copy
Han, Xiaojun, et al. “Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists..” Bioorganic and Medicinal Chemistry Letters, vol. 15, no. 18, Sep. 2005, pp. 4029-4032. https://doi.org/10.1016/j.bmcl.2005.06.028.