Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2.
Publication type: Journal Article
Publication date: 2006-04-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
16480865
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
A novel oxindole was discovered as an HIV non-nucleoside reverse transcriptase inhibitor via HTS using a cell-based assay. Systematic structural modifications were carried out to establish its SAR. These modifications led to the identification of oxindoles with low nanomolar potency for inhibiting HIV replication. These novel and potent oxindoles could serve as advanced leads for further optimizations.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
5
10
15
20
25
|
|
|
Journal of Organic Chemistry
24 publications, 9.41%
|
|
|
Organic and Biomolecular Chemistry
22 publications, 8.63%
|
|
|
European Journal of Organic Chemistry
17 publications, 6.67%
|
|
|
Tetrahedron
16 publications, 6.27%
|
|
|
Organic Letters
15 publications, 5.88%
|
|
|
Tetrahedron Letters
9 publications, 3.53%
|
|
|
Chemistry - A European Journal
9 publications, 3.53%
|
|
|
RSC Advances
7 publications, 2.75%
|
|
|
European Journal of Medicinal Chemistry
6 publications, 2.35%
|
|
|
ChemistrySelect
6 publications, 2.35%
|
|
|
Organic Chemistry Frontiers
6 publications, 2.35%
|
|
|
Molecular Diversity
5 publications, 1.96%
|
|
|
Journal of Molecular Structure
5 publications, 1.96%
|
|
|
Bioorganic and Medicinal Chemistry Letters
5 publications, 1.96%
|
|
|
Synthesis
5 publications, 1.96%
|
|
|
Synlett
5 publications, 1.96%
|
|
|
Asian Journal of Organic Chemistry
4 publications, 1.57%
|
|
|
Advanced Synthesis and Catalysis
4 publications, 1.57%
|
|
|
Monatshefte fur Chemie
3 publications, 1.18%
|
|
|
Chemistry - An Asian Journal
3 publications, 1.18%
|
|
|
ChemCatChem
3 publications, 1.18%
|
|
|
Chemical Communications
3 publications, 1.18%
|
|
|
Chemistry of Heterocyclic Compounds
2 publications, 0.78%
|
|
|
Molecules
2 publications, 0.78%
|
|
|
ChemMedChem
2 publications, 0.78%
|
|
|
Angewandte Chemie - International Edition
2 publications, 0.78%
|
|
|
Angewandte Chemie
2 publications, 0.78%
|
|
|
Journal of Heterocyclic Chemistry
2 publications, 0.78%
|
|
|
Journal of Medicinal Chemistry
2 publications, 0.78%
|
|
|
5
10
15
20
25
|
Publishers
|
10
20
30
40
50
60
70
|
|
|
Wiley
62 publications, 24.31%
|
|
|
Elsevier
56 publications, 21.96%
|
|
|
American Chemical Society (ACS)
49 publications, 19.22%
|
|
|
Royal Society of Chemistry (RSC)
43 publications, 16.86%
|
|
|
Springer Nature
14 publications, 5.49%
|
|
|
Georg Thieme Verlag KG
10 publications, 3.92%
|
|
|
MDPI
5 publications, 1.96%
|
|
|
Taylor & Francis
4 publications, 1.57%
|
|
|
Bentham Science Publishers Ltd.
3 publications, 1.18%
|
|
|
SAGE
1 publication, 0.39%
|
|
|
Scientific Publishers
1 publication, 0.39%
|
|
|
Walter de Gruyter
1 publication, 0.39%
|
|
|
Institute of Chemistry, Academy of Sciences of Moldova
1 publication, 0.39%
|
|
|
Hindawi Limited
1 publication, 0.39%
|
|
|
The Japan Institute of Heterocyclic Chemistry
1 publication, 0.39%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 publication, 0.39%
|
|
|
10
20
30
40
50
60
70
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
255
Total citations:
255
Citations from 2025:
22
(8.62%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Jiang T. et al. Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2. // Bioorganic and Medicinal Chemistry Letters. 2006. Vol. 16. No. 8. pp. 2105-2108.
GOST all authors (up to 50)
Copy
Jiang T., Kuhen K. L., Wolff K., Yin H., Bieza K., Caldwell J., Bursulaya B., Wu T. Y. H., He Y. Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2. // Bioorganic and Medicinal Chemistry Letters. 2006. Vol. 16. No. 8. pp. 2105-2108.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bmcl.2006.01.073
UR - https://doi.org/10.1016/j.bmcl.2006.01.073
TI - Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2.
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Jiang, Tao
AU - Kuhen, Kelli L.
AU - Wolff, Karen
AU - Yin, Hong
AU - Bieza, Kimberly
AU - Caldwell, Jeremy
AU - Bursulaya, Badry
AU - Wu, Tom Yao Hsing
AU - He, Yun
PY - 2006
DA - 2006/04/01
PB - Elsevier
SP - 2105-2108
IS - 8
VL - 16
PMID - 16480865
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2006_Jiang,
author = {Tao Jiang and Kelli L. Kuhen and Karen Wolff and Hong Yin and Kimberly Bieza and Jeremy Caldwell and Badry Bursulaya and Tom Yao Hsing Wu and Yun He},
title = {Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2.},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2006},
volume = {16},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016/j.bmcl.2006.01.073},
number = {8},
pages = {2105--2108},
doi = {10.1016/j.bmcl.2006.01.073}
}
Cite this
MLA
Copy
Jiang, Tao, et al. “Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2..” Bioorganic and Medicinal Chemistry Letters, vol. 16, no. 8, Apr. 2006, pp. 2105-2108. https://doi.org/10.1016/j.bmcl.2006.01.073.