Selective cell adhesion inhibitors: Barbituric acid based α4β7—MAdCAM inhibitors
Тип публикации: Journal Article
Дата публикации: 2008-04-01
scimago Q2
wos Q2
БС2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
18331794
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Краткое описание
A novel series of barbituric acid derivatives were identified as selective inhibitors of alpha4beta7 MAdCAM (mucosal addressin cell adhesion molecule-1) interactions via a high throughput screening exercise. These inhibitors were optimized to submicromolar potencies in whole cell adhesion assays, retaining their selectivity over alpha4beta1 VCAM.
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Метрики
18
Всего цитирований:
18
Цитирований c 2025:
0
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ГОСТ
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Harriman G. C. et al. Selective cell adhesion inhibitors: Barbituric acid based α4β7—MAdCAM inhibitors // Bioorganic and Medicinal Chemistry Letters. 2008. Vol. 18. No. 7. pp. 2509-2512.
ГОСТ со всеми авторами (до 50)
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Harriman G. C., Brewer M., Bennett R. L., Kuhn C., Bazin M., LaRosa G., Skerker P., Cochran N., Gallant D., Baxter D., Picarella D., Jaffee B., Luly J. R., BRISKIN M. J. Selective cell adhesion inhibitors: Barbituric acid based α4β7—MAdCAM inhibitors // Bioorganic and Medicinal Chemistry Letters. 2008. Vol. 18. No. 7. pp. 2509-2512.
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RIS
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TY - JOUR
DO - 10.1016/j.bmcl.2007.07.068
UR - https://doi.org/10.1016/j.bmcl.2007.07.068
TI - Selective cell adhesion inhibitors: Barbituric acid based α4β7—MAdCAM inhibitors
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Harriman, Geraldine C
AU - Brewer, Matthias
AU - Bennett, Robert L.
AU - Kuhn, Cyrille
AU - Bazin, Marc
AU - LaRosa, Greg
AU - Skerker, Paul
AU - Cochran, Nancy
AU - Gallant, Debra
AU - Baxter, Deborah
AU - Picarella, Dominic
AU - Jaffee, Bruce
AU - Luly, Jay R.
AU - BRISKIN, Michael J.
PY - 2008
DA - 2008/04/01
PB - Elsevier
SP - 2509-2512
IS - 7
VL - 18
PMID - 18331794
SN - 0960-894X
SN - 1464-3405
ER -
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BibTex (до 50 авторов)
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@article{2008_Harriman,
author = {Geraldine C Harriman and Matthias Brewer and Robert L. Bennett and Cyrille Kuhn and Marc Bazin and Greg LaRosa and Paul Skerker and Nancy Cochran and Debra Gallant and Deborah Baxter and Dominic Picarella and Bruce Jaffee and Jay R. Luly and Michael J. BRISKIN},
title = {Selective cell adhesion inhibitors: Barbituric acid based α4β7—MAdCAM inhibitors},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2008},
volume = {18},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016/j.bmcl.2007.07.068},
number = {7},
pages = {2509--2512},
doi = {10.1016/j.bmcl.2007.07.068}
}
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MLA
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Harriman, Geraldine C., et al. “Selective cell adhesion inhibitors: Barbituric acid based α4β7—MAdCAM inhibitors.” Bioorganic and Medicinal Chemistry Letters, vol. 18, no. 7, Apr. 2008, pp. 2509-2512. https://doi.org/10.1016/j.bmcl.2007.07.068.