Synthesis and evaluation of novel pyrazolidinone analogs of PGE2 as EP2 and EP4 receptors agonists
Zhong Zhao
1
,
Gian Luca Araldi
1
,
Yufang XIAO
1
,
Adulla P Reddy
1
,
Y.-H. Liao
1
,
Srinivasa Karra
1
,
Nadia Brügger
1
,
David Fischer
2
,
Elizabeth Palmer
2
1
Department of Medicinal Chemistry, EMD Serono Research Institute, Inc., Rockland, MA 02370, USA.
|
2
Department of Lead Discovery, EMD-Serono Research Institute, Inc., Rockland, MA 02370, USA
|
Publication type: Journal Article
Publication date: 2007-12-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
17931866
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
Replacement of the hydroxy cyclopentanone ring in PGE(2) with chemically more stable heterocyclic rings and substitution of the unsaturated alpha-alkenyl chain with a metabolically more stable phenethyl chain led to the development of potent and selective analogs of PGE(2). Compound 10f showed the highest potency and selectivity for EP(4) the receptor.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
|
|
|
RSC Advances
2 publications, 11.76%
|
|
|
Medicinal Chemistry Research
1 publication, 5.88%
|
|
|
Pharmacology and Therapeutics
1 publication, 5.88%
|
|
|
Bioorganic and Medicinal Chemistry Letters
1 publication, 5.88%
|
|
|
Tetrahedron Letters
1 publication, 5.88%
|
|
|
Advanced Synthesis and Catalysis
1 publication, 5.88%
|
|
|
European Journal of Pain
1 publication, 5.88%
|
|
|
Organic Letters
1 publication, 5.88%
|
|
|
Journal of Medicinal Chemistry
1 publication, 5.88%
|
|
|
Synthetic Communications
1 publication, 5.88%
|
|
|
Science
1 publication, 5.88%
|
|
|
Annual Reports in Medicinal Chemistry
1 publication, 5.88%
|
|
|
Mendeleev Communications
1 publication, 5.88%
|
|
|
Journal of Organic Chemistry
1 publication, 5.88%
|
|
|
1
2
|
Publishers
|
1
2
3
4
|
|
|
Elsevier
4 publications, 23.53%
|
|
|
Wiley
3 publications, 17.65%
|
|
|
American Chemical Society (ACS)
3 publications, 17.65%
|
|
|
Royal Society of Chemistry (RSC)
2 publications, 11.76%
|
|
|
Springer Nature
1 publication, 5.88%
|
|
|
Taylor & Francis
1 publication, 5.88%
|
|
|
American Association for the Advancement of Science (AAAS)
1 publication, 5.88%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 publication, 5.88%
|
|
|
1
2
3
4
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
17
Total citations:
17
Citations from 2025:
1
(5.88%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Zhao Z. et al. Synthesis and evaluation of novel pyrazolidinone analogs of PGE2 as EP2 and EP4 receptors agonists // Bioorganic and Medicinal Chemistry Letters. 2007. Vol. 17. No. 23. pp. 6572-6575.
GOST all authors (up to 50)
Copy
Zhao Z., Araldi G. L., XIAO Y., Reddy A. P., Liao Y., Karra S., Brügger N., Fischer D., Palmer E. Synthesis and evaluation of novel pyrazolidinone analogs of PGE2 as EP2 and EP4 receptors agonists // Bioorganic and Medicinal Chemistry Letters. 2007. Vol. 17. No. 23. pp. 6572-6575.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bmcl.2007.09.074
UR - https://doi.org/10.1016/j.bmcl.2007.09.074
TI - Synthesis and evaluation of novel pyrazolidinone analogs of PGE2 as EP2 and EP4 receptors agonists
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Zhao, Zhong
AU - Araldi, Gian Luca
AU - XIAO, Yufang
AU - Reddy, Adulla P
AU - Liao, Y.-H.
AU - Karra, Srinivasa
AU - Brügger, Nadia
AU - Fischer, David
AU - Palmer, Elizabeth
PY - 2007
DA - 2007/12/01
PB - Elsevier
SP - 6572-6575
IS - 23
VL - 17
PMID - 17931866
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2007_Zhao,
author = {Zhong Zhao and Gian Luca Araldi and Yufang XIAO and Adulla P Reddy and Y.-H. Liao and Srinivasa Karra and Nadia Brügger and David Fischer and Elizabeth Palmer},
title = {Synthesis and evaluation of novel pyrazolidinone analogs of PGE2 as EP2 and EP4 receptors agonists},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2007},
volume = {17},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.bmcl.2007.09.074},
number = {23},
pages = {6572--6575},
doi = {10.1016/j.bmcl.2007.09.074}
}
Cite this
MLA
Copy
Zhao, Zhong, et al. “Synthesis and evaluation of novel pyrazolidinone analogs of PGE2 as EP2 and EP4 receptors agonists.” Bioorganic and Medicinal Chemistry Letters, vol. 17, no. 23, Dec. 2007, pp. 6572-6575. https://doi.org/10.1016/j.bmcl.2007.09.074.