Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists
Stefanie Weyler
1
,
Y. Baqi
2
,
Petra Hillmann
2
,
Marko Kaulich
2
,
Andrea M Hunder
2
,
Ingrid B. Müller
3
,
3
Fachhochschule Albstadt-Sigmaringen, University of Applied Sciences, Pharmatechnik, Anton-Günther-Str. 51, D-72488 Sigmaringen, Germany
|
Publication type: Journal Article
Publication date: 2008-01-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
18006312
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
A library of anilinoanthraquinone derivatives was synthesized by parallel Ullmann coupling reaction of bromaminic acid with aniline derivatives in solution using a compact parallel synthesizer. The products were purified by HPLC and evaluated as antagonists at mouse and human P2Y2 receptors. 4-Phenylamino-substituted 1-amino-2-sulfoanthraquinones, for example, 1-amino-4-(2-methoxyphenyl)-2-sulfoanthraquinone (PSB-716), were potent P2Y2 antagonists with IC50 values in the low micromolar range.
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55
Total citations:
55
Citations from 2024:
1
(1.82%)
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GOST
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Weyler S. et al. Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists // Bioorganic and Medicinal Chemistry Letters. 2008. Vol. 18. No. 1. pp. 223-227.
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Weyler S., Baqi Y., Hillmann P., Kaulich M., Hunder A. M., Müller I. B., Müller C. Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists // Bioorganic and Medicinal Chemistry Letters. 2008. Vol. 18. No. 1. pp. 223-227.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bmcl.2007.10.082
UR - https://doi.org/10.1016/j.bmcl.2007.10.082
TI - Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Weyler, Stefanie
AU - Baqi, Y.
AU - Hillmann, Petra
AU - Kaulich, Marko
AU - Hunder, Andrea M
AU - Müller, Ingrid B.
AU - Müller, C.
PY - 2008
DA - 2008/01/01
PB - Elsevier
SP - 223-227
IS - 1
VL - 18
PMID - 18006312
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
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@article{2008_Weyler,
author = {Stefanie Weyler and Y. Baqi and Petra Hillmann and Marko Kaulich and Andrea M Hunder and Ingrid B. Müller and C. Müller},
title = {Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2008},
volume = {18},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.bmcl.2007.10.082},
number = {1},
pages = {223--227},
doi = {10.1016/j.bmcl.2007.10.082}
}
Cite this
MLA
Copy
Weyler, Stefanie, et al. “Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists.” Bioorganic and Medicinal Chemistry Letters, vol. 18, no. 1, Jan. 2008, pp. 223-227. https://doi.org/10.1016/j.bmcl.2007.10.082.