Synthesis and antimycobacterial evaluation of new trans-cinnamic acid hydrazide derivatives
Samir A. Carvalho
1
,
Edson da Silva
1
,
Marcus Vinícius Nora de Souza
1
,
Maria Cristina Lourenço
2
,
Felipe R Vicente
2
2
Instituto de Pesquisas Clı´nica Evandro Chagas – IPEC – Av. Brasil, 4365, Manguinhos, Rio de Janeiro, RJ, Brazil
|
Publication type: Journal Article
Publication date: 2008-01-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
18068364
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
In this work, we report the synthesis and the antimycobacterial evaluation of new trans-cinnamic acid derivatives of isonicotinic acid series (5) and benzoic acid series (6), designed by exploring the molecular hybridization approach between isoniazid (1) and trans-cinnamic acid derivative (3). The minimum inhibitory concentration (MIC) of the compounds 5a–d and 6c exhibited activity between 3.12 and 12.5 μg/mL and could be a good start point to find new lead compounds against multi-drug resistant tuberculosis.
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Total citations:
101
Citations from 2024:
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(6.93%)
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GOST
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Carvalho S. A. et al. Synthesis and antimycobacterial evaluation of new trans-cinnamic acid hydrazide derivatives // Bioorganic and Medicinal Chemistry Letters. 2008. Vol. 18. No. 2. pp. 538-541.
GOST all authors (up to 50)
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Carvalho S. A., da Silva E., de Souza M. V. N., Lourenço M. C., Vicente F. R. Synthesis and antimycobacterial evaluation of new trans-cinnamic acid hydrazide derivatives // Bioorganic and Medicinal Chemistry Letters. 2008. Vol. 18. No. 2. pp. 538-541.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bmcl.2007.11.091
UR - https://doi.org/10.1016/j.bmcl.2007.11.091
TI - Synthesis and antimycobacterial evaluation of new trans-cinnamic acid hydrazide derivatives
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Carvalho, Samir A.
AU - da Silva, Edson
AU - de Souza, Marcus Vinícius Nora
AU - Lourenço, Maria Cristina
AU - Vicente, Felipe R
PY - 2008
DA - 2008/01/01
PB - Elsevier
SP - 538-541
IS - 2
VL - 18
PMID - 18068364
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
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@article{2008_Carvalho,
author = {Samir A. Carvalho and Edson da Silva and Marcus Vinícius Nora de Souza and Maria Cristina Lourenço and Felipe R Vicente},
title = {Synthesis and antimycobacterial evaluation of new trans-cinnamic acid hydrazide derivatives},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2008},
volume = {18},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.bmcl.2007.11.091},
number = {2},
pages = {538--541},
doi = {10.1016/j.bmcl.2007.11.091}
}
Cite this
MLA
Copy
Carvalho, Samir A., et al. “Synthesis and antimycobacterial evaluation of new trans-cinnamic acid hydrazide derivatives.” Bioorganic and Medicinal Chemistry Letters, vol. 18, no. 2, Jan. 2008, pp. 538-541. https://doi.org/10.1016/j.bmcl.2007.11.091.